Sulfonylurea intoxication at a tertiary care paediatric hospital

Canadian Journal of Clinical Pharmacology

Volumn 17, Issue 1, 2010, Pages

  Glatstein, Miguel ^a   Garcia Bournissen, Facundo ^a   Scolnik, Dennis ^a   Koren, Gideon ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Children; Chlorpropamide; Glyburide; Poisoning; Sulfanylurea; Toxicity

Indexed keywords

ACTIVATED CARBON; CHLORPROPAMIDE; GLIBENCLAMIDE; GLUCOSE; OCTREOTIDE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG INTOXICATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INFUSION; GLUCOSE INTAKE; HUMAN; HYPOGLYCEMIA; MALE; PEDIATRIC HOSPITAL; PRESCHOOL CHILD; SCHOOL CHILD; STOMACH LAVAGE; SUICIDE ATTEMPT; TERTIARY HEALTH CARE; TREATMENT RESPONSE;

EID: 77249175305     PISSN: 1198581X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Natahn DM, Rousell A, Godine JE. Glyburide or insulin form metabolic control in non-insulin-dependent diabetes mellitus. A randomized, double-blind study. Ann Intern Med 1988;108(3):334-40.
2. 2+ in mouse pancreatic B-cells following stimulation by hypoglycemic sulphonylureas. FEBS Lett 1985;190:21-4.
3. Gerich JE. Oral hypoglycemic agents. N Engl J Med 1989;321:1231-45.
4. Harrigan RA, Nathan MS, Beattie P. Oral agents for the treatment of type 2 diabetes mellitus: pharmacology, toxicity, and treatment. Ann Emerg Med 2001;38:68-78.
5. Litovitz TL, Klein Scwartz W, Dyer KS, et al. 1997 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1998;16(5):443-7.
6. Selam JL. Pharmacokinetics of hypoglycemic sulfonamides: Ozidia, a new concept. Diabetes Metab 1997;23 Supl 4:39-43.
7. AHFS Drug Information. American Hospital Formulary Service Board of the American Society of Health System Pharmacists 1998;68:2595-7.
8. Szlatenyi CS, Capes KF, Wang RY. Delayed hypoglycemia in a child after ingestion of a single glipizide table. Annals of Emerg Medicine June 1998;31(6):773-6.
9. Hussain K, Mundi H, Aynsley-Green A, Champion M. A child presenting with disordered consciousness, hallucinations, screaming episodes and abdominal pain. Eur J Pediatr 2002;161(2):127-9.
10. Pavone L, Mollica F, Musumeci S, Marino S, Pampigloine G. Accidental Ingestion in an infant, clinical and electroencephalographic aspects. Dev Med Child Neurol 1980;22:366-71.
11. Spiller HA. Management of sulfonylurea ingestions. Pediatr Emerg Care 1999;15(3):227-30.
12. Graudins A, Linden CH, Ferm RP. Diagnosis and treatment of sulphonylurea-induced hyperinsulinaemic hypoglycemia. Am J Emerg Med 1997;15:95-6.
13. Johnson SF, Schade DS, Peake GT. Chlorpropamide-induced hypoglycemia: successful treatment with diazoxide. Am J Med 1977;63:799-804.
14. Lhereux PE, Zahir S, Penaloza A, Gris M. Bench-to-bedside review: Antidotal treatment of sulphonylurea-induced hypoglycaemia with octreotide. Critical Care 2005;9:543-9.
15. McLaughlin SA, Crandall CS, McKinney PE. Octreotide: an antidote for sulphonylurea-induced hypoglycemia. Ann Emerg Med 2000;36:133-8.
16. Matteucci MJ. One pill can kill: assessing the potential for fatal poisoning in children. Pediatr Ann. 2005 Dec;34(12):964.
17. Bar-oz B, Levichek Z, Koren G. Medication that can be fatal for a toddler with one tablet or teaspoonful: a 2004 update. Paediatr Drugs 2004:6(2):123-6.
18. Haymond MW. Hypoglycemia in infants and children. Endocrinol Metab Clin Nort Am 1989;18:211-52.
19. Spiller HA, Schoeder SL, Ching DS. Hemiparesis and altered mental status in a child after glyburide ingestion. J Emerg Med 1998 May-Jun;16(3):433-5.
20. Burkhart KK. When does hypoglycemia develop after sulfonylurea ingestion? Ann Emerg Med 1998;31:771-772.
21. Borowski H, Caraccio T, Mofenson H. Sulfonylurea ingestion in children is an 8-hour observation period sufficient? J Pediatr 1998;133(4):584-5.
22. Kannisto H, Neuvonen PJ. Absorption of sulfonylureas onto activated charcoal in vitro. J Pharma Sci 1984;73:253-5.
23. Rath S, Bar-Zeev N, Anderson K, Fahy R, Roseby R. Octreotide in children with hypoglycaemia due to sulfonylurea ingestion. J Paedtr Child Health 2008;44(6):383-4.
24. Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF. Antidote use in the critically ill poisoned patient. J Intensive Care Med 2006;21(5):255-77.
25. Carr R, Zed PJ. Octreotide for sulfonylurea-induced hypoglycemia following overdose. Ann Pharmacother 2002;36(11):1727-32.
26. Glaser B, Hirsch HJ, Landau H. Persistent hyperinsulinaemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy. J Pediatr 1993;123(4):644-50.
27. Kent DA, Main BA, Friesen MS. Use of octreotide in sulphonylurea poisoning in a child. J Toxicol Clin Toxicol 2003;41:669.
28. Pelavin PI, Abramson E, Pon S, Vogiatzi MG. Extended-release glipizide overdose presenting with delayed hypoglycemia and treated with subcutaneous octreotide. J Pediatr Endocrinol Metab 2009;22(2):171-5.