Physicochemical characterization, in vitro release and permeation studies of respirable rifampicin-cyclodextrin inclusion complexes

Indian Journal of Pharmaceutical Sciences

Volumn 71, Issue 6, 2009, Pages 638-643

  Patil, J S ^a   Suresh, Sarasija ^b  

^a BLDE University Campus   (India)

^b AL AMEEN COLLEGE OF PHARMACY   (India)

Author keywords

cyclodextrins; In vitro release; Inclusion complexes; Rifampicin; Spray drying

Indexed keywords

BETA CYCLODEXTRIN; RIFAMPICIN; SUCRALOSE;

ARTICLE; COMPLEX FORMATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG PURITY; DRUG RELEASE; DRUG SOLUBILITY; IN VITRO STUDY; LUNG FLUID; PARTICLE SIZE; PHYSICAL CHEMISTRY; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING; X RAY DIFFRACTION;

EID: 77249131770     PISSN: 0250474X     EISSN: 19983743     Source Type: Journal    
DOI: 10.4103/0250-474X.59545     Document Type: Article

References (14)

1. Lisa CT, Viness P, Michael PD. Tuberculosis chemotherapy: Current drug delivery approaches. Resp Res 2006;7:118.
2. Prabakaran D, Singh P, Jaganathan KS, Vyas SP. Osmotically regulated asymmetric capsular systems for simultaneous sustained delivery of anti-tubercular drugs. J Control Release 2004;95:239-248
3. Falk R, Randolph TW, Meyer JD, Kelly RM, Manning MC. Controlled release of ionic compounds from poly (L-lactide) microspheres produced by precipitation with a compressed anti-solvent. J Control Release 1997;44:77-85.
4. Pandey R, Sharma A, Zahoor A, Sharma S, Khuller GK, Prasad B. Poly(DL-lactide-co-glycolide) nanoparticle-based inhalable sustained drug delivery system for experimental tuberculosis. J Antimicrob Chemother 2003;52:981-986
5. Ul-Ain O, Sadhana S, Khullar GK, Grag SK. Alginate based oral drug delivery systems for tuberculosis: Pharamacokinetics and therapeutic effects. J Antimicrob Chemother 2003;51:931-938
6. David S. Tuberculosis and non- tuberculosis mico-bacterial infections, 4th ed. Philadelphia; W. B. Saunders's company; 1971, p. 143.
7. Zahoor A, Sharma S, Khullar GK. Inhalabale alginate nano-particles as anti-tubercular drug carriers against experimental tuberculosis. Int J Antimicrob Agent 2005;26:298-303.
8. Gonda I. Systemic delivery of drugs to human via inhalation. J Aerosol Med 2006;19:47-53.
9. Prakashrao B, Sarasija S, Narendra C. Recent advances in cyclodextrin complexes: Mechanistic analysis as permeation enhancer. Indian J Pharm Edu Res 2007;41:102-113
10. Higuchi T, Connors S. Phase solubility techniques. In: Advances in analytical chemistry instrumentation. New York, NY: Wiley Interscience; 1965. p. 117-211.
11. Baboota S, Dhaliwal M, Kohli K. Physicochemical characterization, in vitro dissolution behavior, and pharmacodynamic studies of Rofecoxibcyclodextrin inclusion compounds. Preparation and properties of rofecoxib hydroxypropyl cyclodextrin inclusion complexes: A technical note. AAPS PharmSciTech 2005;6:E83-90.
12. Hara PO, Hickey AJ. Respirable PLGA microspheres containing Rifampicin for the treatment of tuberculosis: Manufacture and characterization. Pharm Res 2000;17:955-961
13. Davis, NM, Feddah MR. A novel method for assessing dissolution of aerosol inhaler products. Int J Pharm 2003;255:175-187
14. Ghosh B, Reddy LH, Kulkarni RV, Khanam J. Comparison of skin permeability of drugs in mice and human cadaver skin. Indian J Exp Biol 2000;38:42-45