Parallel synthesis of novel 3-substituted 1-ethyl-6-methylpyrimido[4,5-c] pyridazine-5,7(1H,6H)-dione Analogs

Synthetic Communications

Volumn 40, Issue 6, 2010, Pages 821-832

  Chen, Yongsheng ^a   Barber, Jack R ^a   Ng, Shi Chung ^a   Zhou, Yuefen ^a  

^a CytRx Corporation   (United States)

Author keywords

1H pyrimido 4,5 c pyridazine 5,7 dione analogs; 6 (1 ethylhydrazinyl) 3 methylpyrimidine 2,4(1H,3H) dione; Cyclization; Parallel synthesis

Indexed keywords

1 ETHYL 3 (2 HYDROXYPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 3 (2 METHOXYPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 3 (3 FLUOROPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 3 (3 HYDROXYPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDNE 5,7(1H,6H) DIONE; 1 ETHYL 3 (3 METHOXYPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 3 (4 FLUOROPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 3 (4 METHOXYPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 3 (5 FLUORO 2 HYDROXYPHENYL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 3 (FURAN 2 YL) 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDNE 5,7(1H,6H) DIONE; 1 ETHYL 6 METHYL 3 (2 OXO 2H CHROMEN 3 YL)PYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 6 METHYL 3 (5 METHYLFURAN 2 YL)PYRIDAZINO[3,4 D]PYRIMIDNE 5,7(1H,6H) DIONE; 1 ETHYL 6 METHYL 3 (NAPHTHALEN 2 YL)PYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 6 METHYL 3 4 TOLYLPYRIMIDO[4,5 C]PYRIDAZINE 5,7(1H,6H) DIONE; 1 ETHYL 6 METHYL 3 [4 (TRIFLUOROMETHOXY)PHENYL]PYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 6 METHYL 3 [4 (TRIFLUOROMETHYL)PHENYL]PYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 1 ETHYL 6 METHYL 3 PHENYLPYRIDAZINO[3,4 D]PYRIMIDNE 5,7(1H,6H) DIONE; 1H PYRIMIDO[4,5 C]PYRIDAZINE 5,7 DIONE DERIVATIVE; 3 (2 CHLOROPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (2,4 DICHLOROPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (2,4 DIFLUOROPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (2,4 DIHYDROXYPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (2,4 DIMETHOXYPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (2,5 DIMETHOXYPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (3 CHLORO 4 FLUOROPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (3 CHLOROPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 3 (4 CHLOROPHENYL) 1 ETHYL 6 METHYLPYRIMIDO[4,5 C]PYRIDAZINE 5,7(1H,6H) DIONE; 3 (5 CHLORO 2 HYDROXYPHENYL) 1 ETHYL 6 METHYLPYRIDAZINO[3,4 D]PYRIMIDINE 5,7(1H,6H) DIONE; 4 (1 ETHYL 6 METHYL 5,7 DIOXO 1,5,6,7 TETRAHYDROPYRIDAZINO[3,4 D]PYRIMIDIN 3 YL)BENZONITRILE; 6 (1 ETHYLHYDRAZINYL) 3 METHYLPYRIMIDINE 2,4(1H,3H) DIONE; PYRIDAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; PURIFICATION;

EID: 77249130911     PISSN: 00397911     EISSN: 15322432     Source Type: Journal    
DOI: 10.1080/00397910903013788     Document Type: Article

References (6)

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