Tertiary butyl alcohol in drinking water induces phase I and II liver enzymes with consequent effects on thyroid hormone homeostasis in the B6C3F1 female mouse

Journal of Applied Toxicology

Volumn 30, Issue 2, 2010, Pages 125-132

  Blanck, O ^a   Fowles, J ^b   Schorsch, F ^a   Pallen, C ^a   Espinasse Lormeau, H ^a   Schulte Koerne, E ^c   Totis, M ^a   Banton, M ^b  

^a BAYER AG   (Germany)

^b LYONDELLBASELL INDUSTRIES   (United States)

^c Evonik Oxeno GmbH   (Germany)

Author keywords

Liver enzymes; P450; Phenobarbital; Risk assessment; Tertiary butyl alcohol; Thyroid adenomas; Thyroid hormones

Indexed keywords

CYTOCHROME; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B10; CYTOCHROME P450 2B9; CYTOCHROME P450 3A11; DRINKING WATER; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 2B1; GLUCURONOSYLTRANSFERASE 2B5; LIOTHYRONINE; LIVER ENZYME; PENTOXYRESORUFIN DEALKYLASE; PHENOBARBITAL; SULFURTRANSFERASE; TERT BUTYL ALCOHOL; THYROID HORMONE; THYROTROPIN; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIRCULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; FEMALE; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; HOMEOSTASIS; HORMONE DETERMINATION; LIVER HYPERTROPHY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ALCOHOL DRINKING; ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCURONOSYLTRANSFERASE; HOMEOSTASIS; LIVER; MICE; MICE, INBRED STRAINS; OXAZINES; PHENOBARBITAL; TERT-BUTYL ALCOHOL; THYROID GLAND; THYROID HORMONES; TIME FACTORS; WATER; WATER SUPPLY;

MUS;

EID: 77249125907     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1478     Document Type: Article

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