Laboratory findings in CD4(+) large granular lymphocytoses

International Journal of Laboratory Hematology

Volumn 32, Issue 1 PART.1, 2010, Pages

  Olteanu, H ^a   Karandikar, N J ^b   Eshoa, C ^c   Kroft, S H ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Medical College of Wisconsin   (United States)

Author keywords

CD4; Flow cytometry; Large granular lymphocytosis; LGL; T cell

Indexed keywords

CD57 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE ANTIGEN;

ADULT; AGED; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CELL STRUCTURE; CLINICAL ARTICLE; CLINICAL FEATURE; CLONAL VARIATION; CYTOPENIA; CYTOTOXIC T LYMPHOCYTE; FEMALE; FLOW CYTOMETRY; FOLLOW UP; GENE EXPRESSION; HUMAN; IMMUNOPHENOTYPING; LABORATORY TEST; LARGE GRANULAR LYMPHOCYTE LEUKEMIA; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SURVIVAL;

ADULT; AGED; ANTIGENS, CD56; ANTIGENS, CD57; CD4-POSITIVE T-LYMPHOCYTES; COHORT STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; LEUKEMIA, LARGE GRANULAR LYMPHOCYTIC; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 77249111373     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2008.01109.x     Document Type: Article

References (27)

1. Barnaba V., Franco A., Paroli M., Benvenuto R., De Petrillo G., Burgio V.L., Santilio I., Balsano C., Bonavita M.S. & Cappelli G. (1994) Selective expansion of cytotoxic T lymphocytes with a CD4+ CD56+ surface phenotype and a T helper type 1 profile of cytokine secretion in the liver of patients chronically infected with Hepatitis B virus. Journal of Immunology 152, 3074 3087.
2. Bigouret V., Hoffmann T., Arlettaz L., Villard J., Colonna M., Ticheli A., Grat- wohl A., Samii K., Chapuis B., Rufer N. & Roosnek E. (2003) Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors. Blood 101, 3198-3204.
3. Chan W.C., Catovsky D., Foucar K. & Montserrat E. (2001) T-cell large granular lymphocyte leukemia. In: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (eds E.S. Jaffe, N.L. Harris, H. Stein & J.W. Vardiman), pp. 197-198. IARC Press, Lyon, France.
4. Dhodapkar M.V., Li C.Y., Lust J.A., Tefferi A. & Phyliky R.L. (1994) Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance? Blood 84, 1620-1627.
5. Garrido P., Ruiz-Cabello F., Barcena P., Sandberg Y., Canton J., Lima M., Ba-lanzategui A., Gonzalez M., Lopez-Ne-vot M.A., Langerak A.W., Garcia-Montero A.C., Almeida J. & Orfao A. (2007) Monoclonal TCR-Vbeta13.1+/ CD4+/NKa+/CD8-/+dim T-LGL lymphocytosis: evidence for an antigen-driven chronic T-cell stimulation origin. Blood 109, 4890-4898.
6. Ghia P., Prato G., Stella S., Scielzo C., Geuna M. & Caligaris-Cappio F. (2007) Age-dependent accumulation of monoclonal CD4+ CD8+ double positive T lymphocytes in the peripheral blood of the elderly. British Journal of Haematology 139, 780-790.
7. Jamal S., Picker L.J., Aquino D.B., McKenna R.W., Dawson D.B. & Kroft S.H. (2001) Immunophenotypic analysis of peripheral T-cell neoplasms. A multipa- rameter flow cytometric approach. American Journal of Clinical Pathology 116, 512-526.
8. Lamy T. & Loughran Jr T.P. (2003) Clinical features of large granular lymphocyte leukemia. Seminars in Hematology 40, 185-195.
9. Lima M., Almeida J., Dos Anjos Teixeira M., Alguero Md Mdel C., Santos A.H., Balanzategui A., Queiros M.L., Barcena P., Izarra A., Fonseca S., Bueno C., Justica B., Gonzalez M., San Miguel J.F. & Orfao A. (2003) TCRalphabeta+/CD4+ large granular lymphocytosis: a new clonal T-cell lymphoproliferative disorder. American Journal of Pathology 163, 763-771.
10. Lundell R., Hartung L., Hill S., Perkins S.L. & Bahler D.W. (2005) T-cell large granular lymphocyte leukemias have multiple phenotypic abnormalities involving pan T-cell antigens and receptors for MHC molecules. American Journal of Clinical Pathology 124, 937-946.
11. Lust J.A. (1996) Molecular genetics and lymphoproliferative disorders. Journal of Clinical Laboratory Analysis 10, 359 367.
12. McKenna R.W., Parkin J., Kersey J.H., Gajl-Peczalska K.J., Peterson L. & Brunning R.D. (1977) Chronic lymphoproliferative disorder with unusual clinical, morphologic, ultrastructural and membrane surface marker characteristics. American Journal of Medicine 62, 588-596.
13. Melenhorst J.J., Sorbara L., Kirby M., Hensel N.F. & Barrett A.J. (2001) Large granular lymphocyte leukaemia is characterized by a clonal T-cell receptor rearrangement in both memory and effector CD8(+) lymphocyte populations. British Journal of Haematology 112, 189-194.
14. Morice W.G., Kurtin P.J., Leibson P.J., Tefferi A. & Hanson C.A. (2003) Demonstration of aberrant T-cell and natural killer-cell antigen expression in all cases of granular lymphocytic leukaemia. British Journal of Haematology 120, 1026-1036.
15. Morice W.G., Kimlinger T., Katzmann J.A., Lust J.A., Heimgartner P.J., Halling K.C. & Hanson C.A. (2004) Flow cyto- metric assessment of TCR-Vbeta expression in the evaluation of peripheral blood involvement by T-cell lympho- proliferative disorders: a comparison with conventional T-cell immunophe- notyping and molecular genetic techniques. American Journal of Clinical Pathology 121, 373-383.
16. O'Malley D.P. (2007) T-cell large granular leukemia and related proliferations. American Journal of Clinical Pathology 127, 850-859.
17. Posnett D.N., Sinha R., Kabak S. & Russo C. (1994) Clonal populations of T cells in normal elderly humans: the T cell equivalent to ''benign monoclonal gammapathy''. Journal of Experimental Medicine 179, 609-618.
18. Richards S.J., Sivakumaran M., Parapia L.A., Balfour I., Norfolk D.R., Kaeda J. & Scott C.S. (1992) A distinct large granular lymphocyte (LGL)/NK-associated (NKa) abnormality characterized by membrane CD4 and CD8 coexpres- sion. The Yorkshire Leukaemia Group. British Journal of Haematology 82, 494-501.
19. Rose M.G. & Berliner N. (2004) T-cell large granular lymphocyte leukemia and related disorders. The Oncologist 9, 247-258.
20. Rossi D., Franceschetti S., Capello D., De Paoli L., Lunghi M., Conconi A. & Gaidano G. (2007) Transient monoclonal expansion of CD8+/CD57+ T-cell large granular lymphocytes after primary cytomegalovirus infection. American Journal of Hematology 82, 1103-1105.
21. Sabnani I., Zucker M.J., Tsang P. & Pale- kar S. (2006) Clonal T-large granular lymphocyte proliferation in solid organtransplant recipients. Transplantation Proceedings 38, 3437-3440.
22. Sala P., Tonutti E., Feruglio C., Florian F. & Colombatti A. (1993) Persistent expansions of CD4+ CD8+ peripheral blood T cells. Blood 82, 1546-1552.
23. Taddesse-Heath L., Feldman J.I., Fahle G.A., Fischer S.H., Sorbara L., Raffeld M. & Jaffe E.S. (2003) Florid CD4+, CD56+ T-cell infiltrate associated with Herpes simplex infection simulating nasal NK-/T-cell lymphoma. Modern Pathology 16, 166-172.
24. de Totero D., Tazzari P.L., DiSanto J.P., di Celle P.F., Raspadori D., Conte R., Gobbi M., Ferrara G.B., Flomenberg N., Lauria F. (1992) Heterogeneous immunophenotype of granular lymphocyte expansions: differential expression of the CD8 alpha and CD8 beta chains. Blood 80, 1765-1773.
25. Van den Hove L.E., Van Gool S.W., Van Poppel H., Baert L., Coorevits L., Van Damme B. & Ceuppens J.L. (1997) Phe- notype, cytokine production and cytolytic capacity of fresh (uncultured) tumour-infiltrating T lymphocytes in human renal cell carcinoma. Clinical and Experimental Immunology 109, 501-509.
26. Viny A.D., Lichtin A., Pohlman B., Loughran T. & Maciejewski J. (2008) Chronic B-cell dyscrasias are an important clinical feature of T-LGL leukemia. Leukemia Lymphoma 49, 932-938.
27. Yasukawa M., Utsunomiya Y., Inoue Y., Kimura N. & Fujita S. (1995) Monoclonal proliferation of CD4+ large granular lymphocytes with cytolytic activity. British Journal of Haematology 91, 419-420.