-
1
-
-
0035934568
-
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial tretament of chronic hepatitis C: A randomized trial
-
Manns MP, McHutchinson JG, Gordon SC, et al. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial tretament of chronic hepatitis C: a randomized trial. Lancet 2001;358:958-65
-
(2001)
Lancet
, vol.358
, pp. 958-965
-
-
Manns, M.P.1
McHutchinson, J.G.2
Gordon, S.C.3
-
2
-
-
0037179698
-
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection
-
Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002;347:975-82
-
(2002)
N Engl J Med
, vol.347
, pp. 975-982
-
-
Fried, M.W.1
Shiffman, M.L.2
Reddy, K.R.3
-
3
-
-
1542378867
-
PEGASYS international study group. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis: A randomized study of treatment duration and ribavirin dose
-
Hadziyannis SJ, Sette H Jr, Morgan TR, et al.; PEGASYS international study group. Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004;140:346-55
-
(2004)
Ann Intern Med
, vol.140
, pp. 346-355
-
-
Hadziyannis, S.J.1
Sette Jr, H.2
Morgan, T.R.3
-
4
-
-
33646852746
-
The prevalence of hepatitis C virus infection in the United States, 1999 through 2002
-
Armstrong GL, Wasley A, Simard EP, et al. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 2006;144:705-14
-
(2006)
Ann Intern Med
, vol.144
, pp. 705-714
-
-
Armstrong, G.L.1
Wasley, A.2
Simard, E.P.3
-
5
-
-
27644542713
-
Chronic hepatitis C: An age wave of disease burden
-
McHutchinson JG, Bacon BR. Chronic hepatitis C: an age wave of disease burden. Am J Manag Care 2005;11:S286-95
-
(2005)
Am J Manag Care
, vol.11
-
-
McHutchinson, J.G.1
Bacon, B.R.2
-
6
-
-
12644279860
-
Prevalence, risk factors, and genotype distribution of hepatitis C virus infection in the general population: A community-based survey in southern Italy
-
Guadagnino V, Stroffolini T, Rapicetta M, et al. Prevalence, risk factors, and genotype distribution of hepatitis C virus infection in the general population: a community-based survey in southern Italy. Hepatology 1997;26:1006-11
-
(1997)
Hepatology
, vol.26
, pp. 1006-1011
-
-
Guadagnino, V.1
Stroffolini, T.2
Rapicetta, M.3
-
7
-
-
20044375378
-
The importance of HCV on the burden of chronic liver disease in Italy: A multicenter prevalence study of 9,997 cases
-
Sagnelli E, Stroffolini T, Mele A, et al. The importance of HCV on the burden of chronic liver disease in Italy: a multicenter prevalence study of 9,997 cases. J Med Virol 2005;75:522-7
-
(2005)
J Med Virol
, vol.75
, pp. 522-527
-
-
Sagnelli, E.1
Stroffolini, T.2
Mele, A.3
-
8
-
-
0027441925
-
The pathology of hepatitis C as a function of mode of transmission: Blood transfusion vs. intravenous drug use
-
Gordon SC, Elloway RS, Long JC, et al. The pathology of hepatitis C as a function of mode of transmission: blood transfusion vs. intravenous drug use. Hepatology 1993;18:1338-43
-
(1993)
Hepatology
, vol.18
, pp. 1338-1343
-
-
Gordon, S.C.1
Elloway, R.S.2
Long, J.C.3
-
9
-
-
0027211013
-
Epidemiology and long term prognosis of hepatitis C virus infection in Japan
-
Yano M, Yatsuhashi H, Inoue O, et al. Epidemiology and long term prognosis of hepatitis C virus infection in Japan. Gut 1993;34:S13-16
-
(1993)
Gut
, vol.34
-
-
Yano, M.1
Yatsuhashi, H.2
Inoue, O.3
-
10
-
-
0030933395
-
-
Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 1997;349:825-32
-
Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet 1997;349:825-32
-
-
-
-
11
-
-
59149083248
-
The history of the "natural history" of hepatitis C (1968-2009)
-
Seeff LB. The history of the "natural history" of hepatitis C (1968-2009). Liver Int 2009;29:(Suppl 1):89-99
-
(2009)
Liver Int
, vol.29
, Issue.SUPPL. 1
, pp. 89-99
-
-
Seeff, L.B.1
-
12
-
-
0026662685
-
Anti-hepatitis C virus in the elderly: A seroepidemiological study in a home for the aged
-
Floreani A, Bertin T, Soffiati G, et al. Anti-hepatitis C virus in the elderly: a seroepidemiological study in a home for the aged. Gerontology 1992;38:214-6
-
(1992)
Gerontology
, vol.38
, pp. 214-216
-
-
Floreani, A.1
Bertin, T.2
Soffiati, G.3
-
13
-
-
0032523315
-
molecular and cellular basis of immunosenescence
-
Solana R, Pawelec G. molecular and cellular basis of immunosenescence. Mech Ageing Dev 1998;102:115-29
-
(1998)
Mech Ageing Dev
, vol.102
, pp. 115-129
-
-
Solana, R.1
Pawelec, G.2
-
14
-
-
1142275269
-
Age-related changes in lymphocyte development and function
-
Linton PJ, Dorshkind K. Age-related changes in lymphocyte development and function. Nat Immunol 2004;5:133-9
-
(2004)
Nat Immunol
, vol.5
, pp. 133-139
-
-
Linton, P.J.1
Dorshkind, K.2
-
15
-
-
68849111675
-
Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence
-
Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J Clin Invest 2009;119:1745-54
-
(2009)
J Clin Invest
, vol.119
, pp. 1745-1754
-
-
Rehermann, B.1
-
16
-
-
67449121348
-
Immune senescence, independent of age, informs the clinical outcome of chronic hepatitis C virus (HCV) infection
-
Hoare M, Gelson W, Das A, et al. Immune senescence, independent of age, informs the clinical outcome of chronic hepatitis C virus (HCV) infection. Hepatology 2008;48(Suppl):780-1A
-
(2008)
Hepatology
, vol.48
, Issue.SUPPL.
-
-
Hoare, M.1
Gelson, W.2
Das, A.3
-
17
-
-
0025190717
-
Decreased expression of heat shock protein 70mRNA and protein after heat treatment in cells of aged rats
-
Fargnoli J, Kunisada T, Fornace AJ, et al. Decreased expression of heat shock protein 70mRNA and protein after heat treatment in cells of aged rats. Proc Natl Acad Sci USA 1990;87:846-50
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 846-850
-
-
Fargnoli, J.1
Kunisada, T.2
Fornace, A.J.3
-
18
-
-
33646365882
-
Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging
-
Zhang HJ, Doctrow SR, Oberley LW, et al. Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging. J Appl Physiol 2006;100:1385-91
-
(2006)
J Appl Physiol
, vol.100
, pp. 1385-1391
-
-
Zhang, H.J.1
Doctrow, S.R.2
Oberley, L.W.3
-
19
-
-
0000158591
-
Increased fibrotic response in the aging liver
-
Ratziu V, Dargere D, Conti M, et al. Increased fibrotic response in the aging liver. Hepatology 2000;32:302A
-
(2000)
Hepatology
, vol.32
-
-
Ratziu, V.1
Dargere, D.2
Conti, M.3
-
20
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky V, Yon M, Dickins RA, et al. Senescence of activated stellate cells limits liver fibrosis. Cell 2008;134:657-67
-
(2008)
Cell
, vol.134
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.A.3
-
21
-
-
0027257453
-
The use of recombinant interferon alfa-2b in elderly patients with anti-HCV-positive chronic active hepatitis
-
Bresci G, Del Corso L, Romanelli AM, et al. The use of recombinant interferon alfa-2b in elderly patients with anti-HCV-positive chronic active hepatitis. J Am Geriatr Soc 1993;41:857-62
-
(1993)
J Am Geriatr Soc
, vol.41
, pp. 857-862
-
-
Bresci, G.1
Del Corso, L.2
Romanelli, A.M.3
-
22
-
-
10244245503
-
Interferon therapy for aged patients with chronic hepatitis C: Improved survival exhibiting a biochemical response
-
Imai Y, Kasahara A, Tanaka H, et al. Interferon therapy for aged patients with chronic hepatitis C: improved survival exhibiting a biochemical response. J Gastroenterol 2004;39:1069-77
-
(2004)
J Gastroenterol
, vol.39
, pp. 1069-1077
-
-
Imai, Y.1
Kasahara, A.2
Tanaka, H.3
-
23
-
-
0028998070
-
Interferon therapy for patients more than 60 years of age with chronic hepatitis C
-
Horiike N, Masumoto T, Nakanishi K, et al. Interferon therapy for patients more than 60 years of age with chronic hepatitis C. J Gastroenterol Hepatol 1995;10:246-9
-
(1995)
J Gastroenterol Hepatol
, vol.10
, pp. 246-249
-
-
Horiike, N.1
Masumoto, T.2
Nakanishi, K.3
-
24
-
-
0742271041
-
Efficacy of interferon treatment (IFN) in elderly patients with chronic hepatitis C
-
Alessi N, Freni MA, Spadaro A, et al. Efficacy of interferon treatment (IFN) in elderly patients with chronic hepatitis C. Infez Med 2003;11:208-12
-
(2003)
Infez Med
, vol.11
, pp. 208-212
-
-
Alessi, N.1
Freni, M.A.2
Spadaro, A.3
-
25
-
-
33845730776
-
Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C
-
Arase Y, Ikeda K, Suzuki F, et al. Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C. Intervirology 2007;50:16-23
-
(2007)
Intervirology
, vol.50
, pp. 16-23
-
-
Arase, Y.1
Ikeda, K.2
Suzuki, F.3
-
26
-
-
64349117396
-
Necessities of interferon therapy in elderly patients with chronic hepatitis C
-
Ikeda K, Arase Y, Kawamura Y, et al. Necessities of interferon therapy in elderly patients with chronic hepatitis C. Am J Med 2009;122:479-86
-
(2009)
Am J Med
, vol.122
, pp. 479-486
-
-
Ikeda, K.1
Arase, Y.2
Kawamura, Y.3
-
27
-
-
33744779670
-
Hepatitis C in 6,865 patients 65 yr or older: A severe and neglected curable disease?
-
Thabut D, Le Calvez S, Thibault V, et al. Hepatitis C in 6,865 patients 65 yr or older: a severe and neglected curable disease? Am J Gastroenterol 2006;101:1260-7
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 1260-1267
-
-
Thabut, D.1
Le Calvez, S.2
Thibault, V.3
-
28
-
-
33644804915
-
Limitation of combination therapy of interferon and ribavirin for older patients with chronic hepatitis C
-
Iwasaki Y, Ikeda H, Araki Y, et al. Limitation of combination therapy of interferon and ribavirin for older patients with chronic hepatitis C. Hepatology 2005;43:54-63
-
(2005)
Hepatology
, vol.43
, pp. 54-63
-
-
Iwasaki, Y.1
Ikeda, H.2
Araki, Y.3
-
29
-
-
33745713940
-
Should aged patients with chronic hepatitis C be treated with interferon and ribavirin combination therapy?
-
Hiramatsu N, Oze T, Tsuda N, et al. Should aged patients with chronic hepatitis C be treated with interferon and ribavirin combination therapy? Hepatol Res 2006;35:185-9
-
(2006)
Hepatol Res
, vol.35
, pp. 185-189
-
-
Hiramatsu, N.1
Oze, T.2
Tsuda, N.3
-
30
-
-
31144432345
-
Efficacy of interferon therapy in elderly patients with chronic hepatitis C
-
Koyama R, Arase Y, Ikeda K, et al. Efficacy of interferon therapy in elderly patients with chronic hepatitis C. Intervirology 2006;49:121-6
-
(2006)
Intervirology
, vol.49
, pp. 121-126
-
-
Koyama, R.1
Arase, Y.2
Ikeda, K.3
-
31
-
-
24944552848
-
Treatment of chronic hepatitis C with interferon alone or combined with ribavirin in Japan
-
Kumada T, Toyoda H, Honda T, et al. Treatment of chronic hepatitis C with interferon alone or combined with ribavirin in Japan. Intervirology 2006;49:112-8
-
(2006)
Intervirology
, vol.49
, pp. 112-118
-
-
Kumada, T.1
Toyoda, H.2
Honda, T.3
-
32
-
-
34347368994
-
Efficacy of ribavirin plus interferon-alpha in patients aged > 60 years with chronic hepatitis C
-
Honda T, Katano Y, Urano F, et al. Efficacy of ribavirin plus interferon-alpha in patients aged > 60 years with chronic hepatitis C. J Gastroenterol Hepatol 2007;22:989-95
-
(2007)
J Gastroenterol Hepatol
, vol.22
, pp. 989-995
-
-
Honda, T.1
Katano, Y.2
Urano, F.3
-
33
-
-
33644653236
-
Are elderly patients poor candidates for pegylated interferon plus ribavirin in the treatment of chronic hepatitis C?
-
Floreani A, Monola E, Carderi I, et al. Are elderly patients poor candidates for pegylated interferon plus ribavirin in the treatment of chronic hepatitis C? J Am Geriatr Soc 2006;54:549-50
-
(2006)
J Am Geriatr Soc
, vol.54
, pp. 549-550
-
-
Floreani, A.1
Monola, E.2
Carderi, I.3
-
34
-
-
34250866397
-
The effect of age on response to therapy with peginterferon alpha plus ribavirin in a cohort of patients with chronic HCV hepatitis including subjects older than 65 yr
-
Antonucci G, Longo MA, Angeletti C, et al. The effect of age on response to therapy with peginterferon alpha plus ribavirin in a cohort of patients with chronic HCV hepatitis including subjects older than 65 yr. Am J Gastroenterol 2007;102:1383-91
-
(2007)
Am J Gastroenterol
, vol.102
, pp. 1383-1391
-
-
Antonucci, G.1
Longo, M.A.2
Angeletti, C.3
-
35
-
-
67650550121
-
Older age is associated with an impaired response to combination pegylated interferon and ribavirin treatment for chronic hepatitis C in a case control study
-
Puoti M, Minola E, Antonini MG, et al. Older age is associated with an impaired response to combination pegylated interferon and ribavirin treatment for chronic hepatitis C in a case control study. J Hepatol 2008;48:S309
-
(2008)
J Hepatol
, vol.48
-
-
Puoti, M.1
Minola, E.2
Antonini, M.G.3
-
36
-
-
77249179003
-
Efficacy and safety of pegylated interferon-alpha plus ribavirin combination therapy in old age chronic hepatitis C patients
-
Dai CY, Huang CF, Yu ML, et al. Efficacy and safety of pegylated interferon-alpha plus ribavirin combination therapy in old age chronic hepatitis C patients. J Hepatol 2009;50:S227
-
(2009)
J Hepatol
, vol.50
-
-
Dai, C.Y.1
Huang, C.F.2
Yu, M.L.3
-
37
-
-
67349254235
-
Poor response to pegylated interferon and ribavirin in older women infected with hepatitis C virus of genotype 1b in high viral loads
-
Sezaki H, Suzuki F, Kawamura Y, et al. Poor response to pegylated interferon and ribavirin in older women infected with hepatitis C virus of genotype 1b in high viral loads. Dig Dis Sci 2009;54:1317-24
-
(2009)
Dig Dis Sci
, vol.54
, pp. 1317-1324
-
-
Sezaki, H.1
Suzuki, F.2
Kawamura, Y.3
-
38
-
-
77249113002
-
Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C
-
Epub ahead of print
-
Honda T, Katano Y, Shimuzu J, et al. Efficacy of peginterferon-alpha-2b plus ribavirin in patients aged 65 years and older with chronic hepatitis C. Liver Int 2009. [Epub ahead of print]
-
(2009)
Liver Int
-
-
Honda, T.1
Katano, Y.2
Shimuzu, J.3
-
39
-
-
70349242026
-
Peginterferon alfa-2a (40kDa) and ribavirin: Comparable rates of sustained virological response in sub-sets of older and younger HCV genotype 1 patients
-
Reddy KJ, Messinger D, Popescu M, et al. Peginterferon alfa-2a (40kDa) and ribavirin: comparable rates of sustained virological response in sub-sets of older and younger HCV genotype 1 patients. J Viral Hepat 2009;16:724-31
-
(2009)
J Viral Hepat
, vol.16
, pp. 724-731
-
-
Reddy, K.J.1
Messinger, D.2
Popescu, M.3
-
40
-
-
0033520109
-
Interferon therapy reduces the risk for hepatocellular carcinoma: National surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of hepatocarcinogenesis by interferon therapy
-
Yoshida H, Shiratori Y, Moriyama M, et al. Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of hepatocarcinogenesis by interferon therapy. Ann Intern Med 1999;131:174-81
-
(1999)
Ann Intern Med
, vol.131
, pp. 174-181
-
-
Yoshida, H.1
Shiratori, Y.2
Moriyama, M.3
-
41
-
-
77249155838
-
Potential negative impact of aging on hepatocarcinogenesis after anti-viral treatment in patients with chronic hepatitis C and benefit of viral eradication by peg-interferon/ribavirin treatment
-
Asahina Y, Izuni N, Hirayama I, et al. Potential negative impact of aging on hepatocarcinogenesis after anti-viral treatment in patients with chronic hepatitis C and benefit of viral eradication by peg-interferon/ribavirin treatment. J Hepatol 2008;48:S7
-
(2008)
J Hepatol
, vol.48
-
-
Asahina, Y.1
Izuni, N.2
Hirayama, I.3
-
42
-
-
38449091418
-
Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis
-
Veldt BJ, Heathcote J, Wedemeyer H, et al. Sustained virologic response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis. Ann Intern Med 2007;147:677-84
-
(2007)
Ann Intern Med
, vol.147
, pp. 677-684
-
-
Veldt, B.J.1
Heathcote, J.2
Wedemeyer, H.3
-
43
-
-
0038352047
-
Cost-effectiveness of treatment for chronic hepatitis C infection in an evolving patient population
-
Salomon JA, Weinstein MC, Hammitt JK, et al. Cost-effectiveness of treatment for chronic hepatitis C infection in an evolving patient population. JAMA 2003;290:228-37
-
(2003)
JAMA
, vol.290
, pp. 228-237
-
-
Salomon, J.A.1
Weinstein, M.C.2
Hammitt, J.K.3
-
44
-
-
34447567165
-
A health economic model to assess the cost-effectiveness of PEG IFN alpha-2-a and ribavirin in patients withy mild chronic hepatitis C
-
Gerkens S, Nechelput M, Annemans L, et al. A health economic model to assess the cost-effectiveness of PEG IFN alpha-2-a and ribavirin in patients withy mild chronic hepatitis C. J Viral Hepat 2007;14:523-36
-
(2007)
J Viral Hepat
, vol.14
, pp. 523-536
-
-
Gerkens, S.1
Nechelput, M.2
Annemans, L.3
-
45
-
-
34447500595
-
A health economic model to assess the cost-effectiveness of pegylated interferon alpha-2-a and ribavirin with moderate chronic hepatitis C and persistently normal alanine aminotransferase levels
-
Gerkens S, Nechelput M, Annemans L, et al. A health economic model to assess the cost-effectiveness of pegylated interferon alpha-2-a and ribavirin with moderate chronic hepatitis C and persistently normal alanine aminotransferase levels. Acta Gastroenterol Belg 2007;70:177-87
-
(2007)
Acta Gastroenterol Belg
, vol.70
, pp. 177-187
-
-
Gerkens, S.1
Nechelput, M.2
Annemans, L.3
-
46
-
-
67349192150
-
Positive and negative prediction of sustained virologic response at weeks 2 and 4 of treatment with albinterferon alfa-2b or peginterferon alfa-2a in treatment-naïve patients with genotype 1, chronic hepatitis C
-
Neumann AU, Pianko S, Zeuzem S, et al. Positive and negative prediction of sustained virologic response at weeks 2 and 4 of treatment with albinterferon alfa-2b or peginterferon alfa-2a in treatment-naïve patients with genotype 1, chronic hepatitis C. J Hepatol 2009;51:21-8
-
(2009)
J Hepatol
, vol.51
, pp. 21-28
-
-
Neumann, A.U.1
Pianko, S.2
Zeuzem, S.3
-
47
-
-
68549115307
-
Virological response at 4 weeks to predict outcome of hepatitis C treatment with pegylated interferon and ribavirin
-
Martinot-Peignoux M, Maylin S, Moucari R, et al. Virological response at 4 weeks to predict outcome of hepatitis C treatment with pegylated interferon and ribavirin. Antivir Ther 2009;14:501-11
-
(2009)
Antivir Ther
, vol.14
, pp. 501-511
-
-
Martinot-Peignoux, M.1
Maylin, S.2
Moucari, R.3
-
48
-
-
65549160381
-
Antiviral resistance and specifically targeted therapy for HCV (STAT-C)
-
Thompson AJ, McHutchison JG. Antiviral resistance and specifically targeted therapy for HCV (STAT-C). J Viral Hepat 2009;16:377-87
-
(2009)
J Viral Hepat
, vol.16
, pp. 377-387
-
-
Thompson, A.J.1
McHutchison, J.G.2
|