α-Synuclein accumulation in skin nerve fibers revealed by skin biopsy in pure autonomic failure

Neurology

Volumn 74, Issue 7, 2010, Pages 608-610

  Shishido, T ^a   Ikemura, M ^b,c   Obi, T ^a   Yamazaki, K ^a   Terada, T ^a   Sugiura, A ^a   Saito, Y ^b   Murayama, S ^b   Mizoguchi, K ^a  

^a SHIZUOKA INSTITUTE OF EPILEPSY AND NEUROLOGICAL DISORDERS   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

(3 IODOBENZYL)GUANIDINE I 131; ALPHA SYNUCLEIN;

AGED; ANAMNESIS; ARTICLE; AUTONOMIC DYSFUNCTION; CASE REPORT; CLINICAL FEATURE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NERVE FIBER; PRIORITY JOURNAL; PURE AUTONOMIC FAILURE; SKIN BIOPSY; SKIN NERVE; SWEAT TEST;

EID: 77149178728     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3181cff6d5     Document Type: Article

References (14)

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3. Kaufmann H, Hague K, Perl D. Accumulation of alpha-synuclein in autonomic nerves in pure autonomic failure. Neurology 2001;56:980-981.
4. Consensus Committee of the American Academy of Neurology. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 1996;46:1470.
5. Michell AW, Luheshi LM, Barker RA. Skin and platelet a-synuclein as peripheral biomarkers of Parkinson's disease. Neurosci Lett 2005;381:294-298.
6. Ikemura M, Saito Y, Sengoku R, et al. Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 2008;67:945-953.
7. Mitsui J, Saito Y, Momose T, et al. Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I- metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease. J Neurol Sci 2006;243:101-104.
8. Hague K, Lento P, Morgello S, Car S, Kaufmann H. The distribution of Lewy bodies in pure autonomic failure: autopsy findings and review of the literature. Acta Neuro-pathol 1997;94:192-196.
9. Arai K, Kato N, Kashiwado K, Hattori T. Pure autonomic failure in association with human a-synucleinopathy. Neurosci Lett 2000;296:171-173.
10. Kaufmann H, Hague K, Perl D. Accumulation of alpha-synuclein in autonomic nerves in pure autonomic failure. Neurology 2001;56:980-981.
11. Consensus Committee of the American Academy of Neurology. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology 1996;46:1470.
12. Michell AW, Luheshi LM, Barker RA. Skin and platelet a-synuclein as peripheral biomarkers of Parkinson's disease. Neurosci Lett 2005;381:294-298.
13. Ikemura M, Saito Y, Sengoku R, et al. Lewy body pathology involves cutaneous nerves. J Neuropathol Exp Neurol 2008;67:945-953.
14. Mitsui J, Saito Y, Momose T, et al. Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I- metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease. J Neurol Sci 2006;243:101-104.