Inhalability of micron particles through the nose and mouth

Inhalation Toxicology

Volumn 22, Issue 4, 2010, Pages 287-300

  King Se, Camby Mei ^a   Inthavong, Kiao ^a   Tu, Jiyuan ^a  

^a RMIT UNIVERSITY   (Australia)

Author keywords

Aspiration efficiency; Computational fluid dynamics; Particle inhalability

Indexed keywords

ADULT; AGED; AIRBORNE PARTICLE; ANTHROPOMETRIC PARAMETERS; ARTICLE; BREATHING; COMPUTATIONAL FLUID DYNAMICS; GEOMETRY; HUMAN; INHALATION; MALE; MOUTH; NOSE; PRIORITY JOURNAL;

ADULT; ALGORITHMS; CHILD; COMPUTER SIMULATION; HEAD; HUMANS; INHALATION EXPOSURE; MANIKINS; MODELS, ANATOMIC; MODELS, STATISTICAL; MOUTH; NANOPARTICLES; NASAL CAVITY; PARTICLE SIZE; REPRODUCIBILITY OF RESULTS;

EID: 77149169388     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958370903295204     Document Type: Article

References (43)

1. ANSYS. CFX v11. Documentation 11. ANSYS.Inc., USA.
2. ANSYS. ICEM CFD 11.0.1. ANSYS.Inc., Pennsylvania, USA.
3. Anthony TR, Flynn MR. 2006a. CFD model for a 3-D inhaling mannequin: Verification and validation. Ann Occup Hyg 50:157-173.
4. Anthony TR, Flynn MR. 2006b. Computational fluid dynamics investigation of particle inhalability. J Aerosol Sci 37:750-765.
5. Anthony TR, Flynn MR, Eisner A. 2005. Evaluation of facial features on particle inhalation. Ann Occup Hyg 49:179-193.
6. Armbruster L, Breuer H. 1982. Investigations into defining inhalable dust. In: Walton WH, ed. Inhaled Particles V. Oxford: Pergamon Press pp. 21-32.
7. Balashazy, I, Hofmann W, Heistracher T. 2003. Local particle deposition patterns may play a key role in the development of lung cancer. J Appl Physiol 94:1719-1725.
8. Baldwin, PEJ, Maynard AD. 1993. A survey of wind speeds in indoor workplaces. Ann Occup Hyg 42:303-313.
9. Bird AJ. 2005. Use of numerical calculations to simulate the sampling efficiency performance of a personal aerosol sampler. Aerosol Sci Technol 39:596-610.
10. Brohus H. 1997. CFD simulation of personal exposure to contaminant sources in ventilated rooms. Paper read at Proceedings of Ventilation '97, The 5th International Symposium on Ventilation for Contaminant Control, Global Developments in Industrial Ventilation, 14-17 September 1997, at Ottawa, Canada.
11. Brohus H, Nielsen PV. 1996. CFD models of persons evaluated by full-scale wind channel experiments. Paper read at Proceedings of Roomvent '96, 5th International Conference on Air Distribution in Rooms, 17-19 July 1996, at Yokohama, Japan.
12. Chung IP, Trinh T, Dunn-Rankin D. 1997. Experimental investigation of a twodimensional cylindrical sampler. J Aerosol Sci 25:935-955.
13. Chung KYK, Cuthber RJ, Revell GS, Wassel SG, Summer N. 2000. A study on dust emission, particle size distribution and formaldehyde concentration during machining of medium density fibreboard. Ann Occup Hyg 44:455-466.
14. Crowder TM, Rosati JA, Schroeter JD, Hickey AJ, Martonen TB. 2002. Fundamental effects of particle morphology on lung delivery: Predictions of Stokes law and the particular relevance to dry powder inhaler formulation and development. Pharm Res 19:239-245.
15. Dunnet SJ, Ingham DB. 1988. The human head as a blunt aerosol sampler. J Aerosol Sci 19:365-380.
16. Durbin PA. 1995. Separated flow computations with the k-epsilon-v-squared model. AIAA J 33:659-664.
17. Erdal S, Esment A. 1995. Human head model as an aerosol sample: Calculation of aspiration efficiencies for coarse particles using an idealised human head model facing the wind. J Aerosol Sci 33:237-255.
18. Guilmette RA, Cheng YS, Yeh HC, Swift DL. 1994. Deposition of 0.005-12μm monodisperse particles in a computer-milled, MRI-based nasal airway replica. Inhal Toxicol 6(S1):395-399.
19. Heist DK, Eisner AD, Mitchell W, Wiener R. 2003. Airflow around a childsize manikin in a low-speed wind environment. Aerosol Sci Technol 37:303-314.
20. Hsu DJ, Swiftt Dl. 1999. The measurements of human inhalability of ultralarge aerosols in calm air using mannikins. J Aerosol Sci 30:1131-1343.
21. Hyun S, Kleinstreuer C. 2001. Numerical simulation of mixed convection heat and mass transfer in a human inhalation test chamber. Int J Heat Mass Transfer 44:2247-2260.
22. Ingham DB, Hildyard ML. 1991. The fluid-flow into a blunt aerosol samper oriented at an angle to the oncoming flow. J Aerosol Sci 22:235-252.
23. Inthavong K. 2006. A numerical study into local deposition sites in the nasal cavity for therapeutic and pollutant inhalation. In: Ansys Australasian Users Conference Proceedings 22-23 November 2006. Melbourne, Australia.
24. Inthavong K, Tian ZF, Li HF, Tu JY, Yang W, Xue CL, Li CG. 2006. Local deposition sites of drug particles in a human nasal cavity. Paper read at Fifth International Conference on CFD in the Process Industries, 13-15th December, 2006, at Melbourne, Australia.
25. Inthavong K, Tian ZF, Tu JY. 2009a. Effect of ventilation design on removal of particles in woodturning workstations. Build Environ 44:125-136.
26. Inthavong K, Tu JY, Ahmadi G. 2009b. Computational modelling of gas-particle flows with different particle morphology in the human nasal cavity. J Comput Multiphase Flows 1(1):57-82.
27. Inthavong K, Yong Y, Ding S, Tu JY, Subic A, Thien F. 2008a. Comparative study of the effects of acute asthma in relation to a recovered airway tree on airflow patterns. Presented at 13th International Conference on Biomedical Engineering (ICBME2008). Singapore.
28. Inthavong K, Yong Y, Ding S, Tu JY, Subic A, Thien F. 2008b. Airway geometry and inhalation effort comparisons in a narrowed and recovered airway caused by acute asthma. In: International Conference on Audio, Language and Image Processing 2008 (ICALIP2008, Paper 581). Shanghai, China: IEEE.
29. Kennedy NJ, Hinds WC. 2002. Inhalability of large solid particles. J Aerosol Sci 33:237-255.
30. Kleinstreuer C, Zhang Z. 2003. Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumours. J Biomech Eng 125:197-206.
31. Menter FR, Esch T. 2001. Elements of Industrial Heat Transfer Predictions. Paper read at 16th Brazilan Congress of Mechanical Engineering (COBEM), at Uberlandia, Brazil.
32. Ogden TL, Birkett JL. 1977. The human head as a dust sampler. In: Walton WH, ed. Inhaled Particles IV. Oxford: Pergamon Press.
33. Schiller L, Naumann A. 1933. A drag coefficient. Correlation. Z Ver Dtsch Ing 77:318-320.
34. Shi H, Kleinstreuer C, Zhang Z. 2008. Dilute suspension flow with nanoparticle deposition in a representative nasal airway model. Phys Fluids 20:1-23.
35. Singularity Inversion, Inc. 2007. FaceGEN Modeller.
36. Snyer WS, Cook MJ, Nasset ES, Karhausen LR, Parry Howells G, Tipton IH. 1975. Report of the Task Group on Reference Man, International Commission on Radiolofical Protection. Oxford: Pergamon Press.
37. Speziale CG, Thangam S. 1992. Analysis of an RNG based turbulence model for separated flows. Int J Eng Sci 30:1379-1388.
38. Tian ZF, Inthavong K, Tu JY. 2007. Deposition of inhaled wood dust in the nasal cavity. Inhal Toxicol 19:1155-1165.
39. Tilley AR. 1993. The Measure of Man and Woman. New York: The Whitney Library of Design.
40. Vincent JH, ed. 1999. Particle Size-Selective Sampling for Particulate Air Contaminants. Cincinnati: American Conference of Governmental Industrial Hygienists.
41. Vincent JH, Mark D. 1982. Application of blunt sampler theory to the definition and measurement of inhalable dust. In: Walton WH, ed. Inhaled Particles V. Oxford: Pergamon Press.
42. Zhu S, Kato S, Murakami S, Hayashi T. 2005. Study on inhalation region by means of CFD analysis and experiment. Build Environ 40:1329-1336.
43. Zwartz GJ, Guilmette RA. 2001. Effect of flow rate on particle deposition in a replica of a human nasal airway. Inhal Toxicol 13:109-127.