PTPN1 polymorphisms are associated with total and low-density lipoprotein cholesterol

European Journal of Preventive Cardiology

Volumn 17, Issue 1, 2010, Pages 28-34

  Bauer, Florianne ^a,b   Charlotte, Onland Moret N ^a,b   Niehoff, Anne G ^a,b   Elbers, Clara C ^a,b   Grobbee, Diederick E ^b   Wijmenga, Cisca ^a,c   van der Schouw, Yvonne T ^b  

^a Department of Medical Genetics DBG   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

association study; low density lipoprotein cholesterol; metabolic endophenotypes; PTPN1; total cholesterol

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; PROTEIN TYROSINE PHOSPHATASE 1B;

ADULT; AGED; ALLELE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA POLYMORPHISM; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD PRESSURE; BODY MASS INDEX; CHOLESTEROL; CHOLESTEROL, LDL; CROSS-SECTIONAL STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INSULIN RESISTANCE; LINEAR MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NETHERLANDS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RISK ASSESSMENT; RISK FACTORS; WAIST CIRCUMFERENCE;

EID: 77149158484     PISSN: 20474873     EISSN: 20474881     Source Type: Journal    
DOI: 10.1097/HJR.0b013e32832d30c4     Document Type: Article

References (22)

1. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2diabetes. Nature 2006; 44: 840–846.
2. Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain. Science 2005; 307: 375–379.
3. Bence KK, Delibegovic M, Xue B, Gorgun CZ, Hotamisligil GS, Neel BG, Kahn BB. Neuronal PTP1B regulates body weight, adiposity and leptinaction. Nat Med 2006; 12: 917–924.
4. Byon JC, Kusari AB, Kusari J. Protein-tyrosine phosphatase-1B acts as a negative regulator ofinsulin signal transduction. Mol Cell Biochem 1998; 182: 101–108.
5. Spencer-Jones NJ, Wang X, Snieder H, Spector TD, Carter ND, O'Dell SD. Protein tyrosine phosphatase-1B gene PTPN1: selection of taggingsingle nucleotide polymorphisms and association with body fat, insulinsensitivity, and the metabolic syndrome in a normal femalepopulation. Diabetes 2005; 54: 3296–3304.
6. Grundy M, Diane Becker RN, Clark LT, Cooper RS, Denke MA, James Howard WM, et al. Executive Summary of The Third Report ofThe National Cholesterol Education Program (NCEP) Expert panel on detection,evaluation, and treatment of high blood cholesterol in adults (AdultTreatment Panel III). JAMA 2001; 285: 2486–2497.
7. Rondinone CM, Trevillyan JM, Clampit J, Gum RJ, Berg C, Kroeger P, et al. Protein tyrosine phosphatase 1B reductionregulates adiposity and expression of genes involved inlipogenesis. Diabetes 2002; 51: 2405–2411.
8. Di Paola R, Frittitta L, Miscio G, Bozzali M, Baratta R, Centra M, et al. A variation in 3′ UTR ofhPTP1B increases specific gene expression and associates with insulinresistance. Am J Hum Genet 2002; 70: 806–812.
9. Palmer ND, Bento JL, Mychaleckyj JC, Langefeld CD, Campbell JK, Norris JM, et al. Association of protein tyrosinephosphatase 1B gene polymorphisms with measures of glucose homeostasis inHispanic Americans: the insulin resistance atherosclerosis study (IRAS)family study. Diabetes 2004; 53: 3013–3019.
10. Ukkola O, Rankinen T, Lakka T, Leon AS, Skinner JS, Wilmore JH, et al. Protein tyrosine phosphatase 1B variantassociated with fat distribution and insulin metabolism. Obes Res 2005; 13: 829–834.
11. Cheyssac C, Lecoeur C, Dechaume A, Bibi A, Charpentier G, Balkau B, et al. Analysis of common PTPN1 gene variants intype 2 diabetes, obesity and associated phenotypes in the Frenchpopulation. BMC Med Genet 2006; 7: 44.
12. Olivier M, Hsiung CA, Chuang LM, Ho LT, Ting CT, Bustos VI, et al. Single nucleotide polymorphisms inprotein tyrosine phosphatase 1beta (PTPN1) are associated with essentialhypertension and obesity. Hum Mol Genet 2004; 13: 1885–1892.
13. Dahlman I, Wahrenberg H, Persson L, Arner P. No association of reported functional protein tyrosinephosphatase 1B 3’ UTR gene polymorphism with features of themetabolic syndrome in a Swedish population. J InternMed 2004; 255: 694–695.
14. Florez JC, Agapakis CM, Burtt NP, Sun M, Almgren P, Rastam L, et al. Association testing of the proteintyrosine phosphatase 1B gene (PTPN1) with type 2 diabetes in 7883people. Diabetes 2005; 54: 1884–1891.
15. Bento JL, Palmer ND, Mychaleckyj JC, Lange LA, Langefeld CD, Rich SS, et al. Association of protein tyrosinephosphatase 1B gene polymorphisms with type 2 diabetes. Diabetes 2004; 53: 3007–3012.
16. Muller M, Grobbee DE, den Tonkelaar I, Lamberts SW, van der Schouw YT. Endogenous sex hormones and metabolic syndrome in agingmen. J Clin Endocrinol Metab 2005; 90: 2618–2623.
17. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoproteincholesterol in plasma, without use of the preparativeultracentrifuge. Clin Chem 1972; 18: 499–502.
18. Hrebicek J, Janout V, Malincikova J, Horakova D, Cizek L. Detection of insulin resistance by simple quantitative insulinsensitivity check index QUICKI for epidemiological assessment andprevention. J Clin Endocrinol Metab 2002; 87: 144–147.
19. De Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. Efficiency and power in genetic associationstudies. Nat Genet 2005; 37: 1217–1223.
20. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA. Score tests for association between traits and haplotypes whenlinkage phase is ambiguous. Am J Hum Genet 2002; 70: 425–434.
21. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate: a practical and powerfulapproach to multiple testing. J Roy Stat Soc B Met 1995; 57: 289–300.
22. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accuratemethod for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402–2410.