Potential for revealing individual-level information in genome-wide association studies

JAMA

Volumn 303, Issue 7, 2010, Pages 659-660

  Lumley, Thomas ^a   Rice, Kenneth ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME; INFORMATION; NOTE; PREDICTION; PRIORITY JOURNAL;

EID: 77149156989     PISSN: 00987484     EISSN: 15383598     Source Type: Journal    
DOI: 10.1001/jama.2010.120     Document Type: Note

References (10)

1. Pearson TA, Manolio TA. How to interpret a genome-wide association study. JAMA. 2008;299(11):1335-1344.
2. Hunter DJ, Kraft P. Drinking from the fire hose-statistical issues in genomewide association studies. N Engl J Med. 2007;357(5):436-439.
3. Johnson AD, O'Donnell CJ. An open access database of genome-wide association results. BMC Med Genet. 2009;10:6.
4. Homer N, Szelinger S, Redman M, et al. Resolving individuals contributing trace amounts of DNA to highly complex mixtures using high-density SNP genotyping microarrays. PLoS Genet. 2008;4(8):e1000167.
5. Sankararaman S, Obozinski G, Jordan MI, Halperin E. Genomic privacy and limits of individual detection in a pool. Nat Genet. 2009;41(9):965-967.
6. Jacobs KB, Yeager M, Wacholder S, et al. A new statistic and its power to infer membership in a genome-wide association study using genotype frequencies. Nat Genet. 2009;41(11):1253-1257.
7. Visscher PM, Hill WG. The limits of individual identification from sample allele frequencies: theory and statistical analysis [published online October 2, 2009]. PLoS Genet. 2009;5(10):e1000628. doi:10.1371/journal.pgen. 1000628.
8. Vasan RS, Glazer NL, Felix JF, et al. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA. 2009;302(2):168-178.
9. Hastie T, Tibshirani R, Friedman J. The Elements of Statistical Learning: Data Mining, Inference and Prediction. New York, NY: Springer-Verlag; 2001.
10. McGuire AL, Burke W. An unwelcome side effect of direct-to-consumer personal genome testing: raiding the medical commons. JAMA. 2008;300(22): 2669-2671.