Safety and toxicological evaluation of a novel anti-obesity formulation LI85008F in animals

Toxicology Mechanisms and Methods

Volumn 20, Issue 2, 2010, Pages 59-68

  Krishnaraju, A V ^a   Sundararaju, D ^a   Srinivas, P ^a   Rao, C V ^a   Sengupta, K ^a   Trimurtulu, G ^a  

^a Laila Impex R and D Centre   (India)

Author keywords

Acute dermal toxicity; Acute oral toxicity; Curcuma longa; LI85008F; Moringa oleifera; Murraya koenigii; Primary dermal irritation; Primary eye irritation; Sub acute toxicity

Indexed keywords

ADIPONECTIN; ANTIOBESITY AGENT; LI 85008 F; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG FORMULATION; DRUG SAFETY; EYE IRRITATION; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; LIPID DEGRADATION; MALE; NONHUMAN; OBESITY; ORGAN WEIGHT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RABBIT; RAT; SCORING SYSTEM; SKIN IRRITATION; WEIGHT GAIN;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ANIMALS; ANTI-OBESITY AGENTS; CHEMISTRY, PHARMACEUTICAL; CURCUMA; DOSE-RESPONSE RELATIONSHIP, DRUG; EYE; FEMALE; LETHAL DOSE 50; MALE; MEDICINE, AYURVEDIC; MORINGA OLEIFERA; MURRAYA; NO-OBSERVED-ADVERSE-EFFECT LEVEL; PLANT PREPARATIONS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT; SKIN; SKIN IRRITANCY TESTS; TIME FACTORS;

ANIMALIA; CURCUMA LONGA; MORINGA OLEIFERA; MURRAYA; MURRAYA KOENIGII; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 77149152223     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376510903483722     Document Type: Article

References (18)

1. Arulselvan P, Subramanian SP. 2007. Beneficial effects of Murraya koenigii leaves on antioxidant defense system and ultra structural changes of pancreatic beta-cells in experimental diabetes in rats. Chem Biol Interact 165:155-164.
2. Bhavani STN, Shantha NV, Ramesh HP, Murthy IAS, Murray VS. 1980. Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guinea pigs and monkeys. Indian J Exp Biol 18:73-75.
3. Chopra RN, Nayer SL, Chopra IC. 1956. Glossary of Indian medicinal plants. New Delhi, India: CSIR. pp 170.
4. Dolly J, Prashant KR, Amit K, Shikha M, Geeta W. 2009. Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmacol 123:392-396.
5. Draize JH. 1965. The appraisal of the safety of chemicals in foods, drugs and cosmetics. Dermal toxicity. Topeka, KS: Association of Food and Drug Officials of the US. pp 46-59.
6. Draize JH, Woodward G, Calvary HO. 1944. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther 82:377-390.
7. Ishita C, Kaushik B, Uday B, Ranajit KB. 2004. Turmeric and curcumin: bologi-cal actions and medicinal applications. Curr Sci 87:44-53. http://iccvam.niesh.nih.gov/suppDocs/fedDocs/EPA/EPA-870-2500.pdf.
8. Kay JH, Calandra JC. 1962. Interpretation of eye irritation tests. J Soc Cos Chem 13:281-289.
9. Lawal HA, Atiku MK, Khelpai DG, Wannang NN. 2008. Hypoglycemic and hypolipidaemic effects of the aqueous extract of Murraya koenigii in normal and alloxan diabetic rats. Nigerian J Physiol Sci 23:37-40.
10. Nadkarni KM, Nadkarni AK. 1976. The Indian Materia Medica. Bombay, India: Popular Prakasan. pp 810.
11. OECD guide lines for testing of chemicals updated on luly 1995. http://www.oecd.org/dataoecd/9/ll/33663321.pdf.
12. Pullaiah T. 2006. Encyclopedia of world medicinal plants. New Delhi, India: Regency Publications, pp 1380.
13. Reagan-Shaw S, Nihal M, Nihal A. 2007. Dose translation from animal to human studies revised. FASEB 122:659-661.
14. Sambaiah K, Ratankumar S, Kamanna VS, Satyanarayana MN, Rao MVL. 1982. Influence of turmeric and curcumin on growth, blood constituents and serum enzymes in rats. J Food Sci Technol 19:187-190.
15. Sastri BN. 1962. The wealth of India-raw materials VI. New Delhi, India: CSIR.
16. Tachibana Y, Kikuzaki H, Lajis NH, Nakatani N. 2003. Comparison of antioxidative properties of carbazole alkaloids from Murraya koenigii leaves. J Agric Food Chem 51:6461-6467.
17. Xie JT, Chang WT, Mehendale, SR. et al. 2006. Curry leaf (Murraya koenigii Spreng) reduces blood cholesterol and blood glucose levels in ob/ob mice. Am J Chin Med 34:279-284.
18. Yadav S, Vats V, Dhunnoo Y, Grover JK. 2002. Hypoglycemic and antihyperglycemic activity of Murraya koenigii leaves in diabetic rats. J Ethnopharmacol 82:111-116.