Futility interim monitoring with control of type I and II error probabilities using the interim Z-value or confidence limit

Clinical Trials

Volumn 6, Issue 6, 2009, Pages 565-573

  Lachin, John M ^a  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL ERROR; ARTICLE; CLINICAL RESEARCH; DATA ANALYSIS; HEALTH STATISTICS; METHODOLOGY; PRIORITY JOURNAL; PROBABILITY; STATISTICAL ANALYSIS;

CLINICAL TRIALS AS TOPIC; DATA INTERPRETATION, STATISTICAL; DECISION MAKING; HUMANS; PROBABILITY; RESEARCH DESIGN;

EID: 77149150913     PISSN: 17407745     EISSN: 17407753     Source Type: Journal    
DOI: 10.1177/1740774509350327     Document Type: Article

References (10)

1. Lachin JM. A review of methods for futility stopping based on conditional power. Stat Med 2005;18:2747-64.
2. Lachin JM. Biostatistical Methods: The Assessment of Relative Risks. Wiley, New York, 2000.
3. Lachin JM. Maximum Information Designs. Clin Trials 2005;2:453-64.
4. Tsiatis AA. Repeated significance testing for a general class of statistics used in censored survival analysis. J Am Stat Assoc 1982;77:855-61.
5. Lan KKG, Lachin JM. Group sequential logrank tests in a maximum duration trial. Biometrics 1990;46:759-70.
6. Peto R, Pike MC, Armitage P et al. Design and analysis of randomised clinical trials requiring prolonged observation of each patient. Introduction and design. Br J Cancer 1976;34:585-612.
7. Jennison C, Turnbull B. Group Sequential Methods with Applications to Clinical Trials. Chapman Hall/CRC, Boca Raton, 1999.
8. Pampallona S, Tsiatis AA, Kim KM. Interim monitoring of group sequential trials using spending functions for the type I and type II error probabilities. Drug Inf J 2001;35:1113-21.
9. Lan KKG, Wittes J. The B-value: A tool for data monitoring. Biometrics 1988;44:579-85.
10. Lan KKG, Zucker DM. Sequential monitoring of clinical trials: The role of information and Brownian motion. Stat Med 1993;12:753-65.