Perfluorocarbon-filled poly(lactide-co-gylcolide) nano- and microcapsules as artificial oxygen carriers for blood substitutes: A physico-chemical assessment

Journal of Microencapsulation

Volumn 27, Issue 2, 2010, Pages 122-132

  Bauer, J ^a   Zahres M ^a   Zellermann, A ^a   Kirsch, M ^a   Petrat, F ^a   De Groot, H ^a   Mayer, C ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Blood replacement; Gas exchange; Nanocapsules; Oxygen carrier; Perfluorocarbon; Poly lactide glycolide

Indexed keywords

DRUG CARRIER; FLUORESCENT DYE; FLUOROCARBON; NANOCAPSULE; OXYGEN; PERFLUORODECALIN; POLYGLACTIN; BLOOD SUBSTITUTE; MICROCAPSULE;

AQUEOUS SOLUTION; ARTICLE; ATOMIC FORCE MICROSCOPY; BIODEGRADABILITY; BIOMECHANICS; CHEMICAL STRUCTURE; CONFOCAL LASER MICROSCOPY; DISPERSION; ERYTHROCYTE; GAS EXCHANGE; GAS PERMEABILITY; MICROCAPSULE; MICROENCAPSULATION; MOLECULAR STABILITY; NANOCHEMISTRY; NUCLEAR MAGNETIC RESONANCE; OXYGEN CONSUMPTION; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARTICLE SIZE; ULTRASTRUCTURE;

BLOOD SUBSTITUTES; CAPSULES; FLUOROCARBONS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ATOMIC FORCE; NANOCAPSULES; PARTICLE SIZE; POLYGLACTIN 910;

EID: 77149144795     PISSN: 02652048     EISSN: 14645246     Source Type: Journal    
DOI: 10.3109/02652040903052002     Document Type: Article

References (20)

1. Altinbas N, Fehmer C, Terheiden A, Shukla A, Rehage H, Mayer C. 2006. Alkylcyanoacrylate nanocapsules prepared from mini-emulsions: A comparison with the conventional approach. J Microencapsulation 23:567-581.
2. Chang TMS. 2004. Artificial cells for cell and organ replacements. Artif Organs 28:265-270.
3. Chang TMS. 2003. Future generations of red blood cell substitutes. J Intern Med 253:527-535.
4. Chang TMS. 1964. Semipermeable microcapsules. Science 146:524-525.
5. Clark LC, Gollan F. 1966. Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science 152:1755-1756.
6. Fery A, Weinkammer R. 2007. Mechanical properties of micro- and nanocapsules: Single-capsule measurements. Polymer 48:7221-7235.
7. Finder C, Wohlgemuth M, Mayer C. 2004. Analysis of particle size distribution by particle tracking. Part Part Syst Charact 21:372-378.
8. Fung BM. 1983. Selective detection of multiplets via double quantum coherence: A Org Magn Reson 21:397-398.
9. Komura S, Tamura K, Kato T. 2005. Buckling of spherical shells adhering onto a rigid substrate. Eur Phys J E 18:343-358.
10. Kost J, Leong K, Langer R. 1989. Ultrasound-enhanced polymer degradation and release of incorporated substances. Proc Natl Acad Sci USA 86:7663-7666.
11. Lowe KC. 2003. Engineering blood: Synthetic substitutes from flourinated compounds. Tissue Eng 9:389-399.
12. Loxley A, Vincent B. 1998. Preparation of poly(methylmethacrylate) microcapsules with liquid cores. J Colloid Interface Sci 208:49-62.
13. Pisani E, Tsapis N, Paris J, Nicolas V, Cattel L, Fattal E. 2006. Polymeric nano/microcapsules of liquid perfluorocarbons for ultrasonic imaging: Physical characterization. Langmuir 22:4397-4402.
14. Reed AM, Gilding DK. 1981. Biodegradable polymers for use in surgery- poly(glycolic)/polymer(lactic acid) homo and copolymers 2. In vitro degradation. Polymer 22:494-498.
15. Riess JG. 2001. Oxygen carriers ('blood substitutes')-raison d'être, chemistry, and some physiology. Chem Rev 101:2797-2919.
16. Riess JG. 1984. Reassessment of criteria for the selection of perfluorochemicals for 2nd generation blood substitutes-analysis of structure property relationships. Artif Organs 8:44-56.
17. Sloviter HA, Kamimoto T. 1967. Erythrocyte substitute for perfusion of brain. Nature 216:458-460.
18. Winslow RM. 2006. Current status of oxygen carriers ('blood substitutes'): 2006 91:102-110.
19. Yamaguchi K, Anderson JM. 1993. In vivo biocompatibility studies of Medisorb® 65/35 D,L-lactide/glycolide copolymer microspheres. J Contr Rel 24:81-93.
20. Yu WP, Chang TMS. 1994. Submicron biodegradable polymer membrane hemoglobin nanocapsules as potential blood substitutes: A preliminary report. Artif Cells Blood Subs Immob Biotech 22:889-893.