Protease-activated receptor 2 blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure

Shock

Volumn 33, Issue 3, 2010, Pages 339-

  Spek, C Arnold ^a   Brüggemann, Lois W ^a   Borensztajn, Keren S ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; ENDOTOXIN; FIBRIN; LIPOPOLYSACCHARIDE; PEPTIDE; PROTEASE ACTIVATED RECEPTOR 2 ANTAGONIST; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 2 BLOCKING PEPTIDE; SC 9278 P; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD CLOTTING; CREATININE BLOOD LEVEL; DRUG TARGETING; EXPERIMENTAL MODEL; INFLAMMATION; KIDNEY FUNCTION; LETTER; NONHUMAN; RAT; SEPSIS; UREA BLOOD LEVEL; WESTERN BLOTTING;

ANIMALS; DISEASE MODELS, ANIMAL; ENDOTOXINS; INFLAMMATION; KIDNEY FAILURE, ACUTE; LIPOPOLYSACCHARIDES; PEPTIDES; RATS; RECEPTOR, PAR-2;

EID: 77149124585     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181b433c0     Document Type: Letter

References (5)

1. Jesmin S, Gando S, Zaedi S, Prodhan SH, Sawamura A, Miyauchi T, Hiroe M, Yamaguchi N: Protease-activated receptor 2 (PAR2) blocking pep-tide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure. Shock 32(6):626-632, 2009.
2. Ossovskaya VS, Bunnett NW: Protease-activated receptors: contribution to physiology and disease. Physiol Rev 84:579-621, 2004.
3. Borensztajn K, Peppelenbosch MP, Spek CA: Factor Xa: at the crossroads between coagulation and signaling in physiology and disease. Trends Mol Med 14:429-440, 2008.
4. Bushell T: The emergence of proteinase-activated receptorY2 as a novel target for the treatment of inflammation-related CNS disorders. J Physiol 581:7-16, 2007.
5. Shpacovitch V, Feld M, Hollenberg MD, Luger TA, Steinhoff M: Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity. J Leukoc Biol 83:1309-1322, 2008.