α-Glucosidase inhibitory, aromatase inhibitory, and antiplasmodial activities of a biflavonoid gb1 from garcinia kola stem bark

Planta Medica

Volumn 76, Issue 3, 2010, Pages 276-277

  Antia, Bassey S ^a,b   Pansanit, Acharavadee ^c   Ekpa, Okon D ^b   Ekpe, Udofot J ^b   Mahidol, Chulabhorn ^a,c,d   Kittakoop, Prasat ^a,c  

^a CHULABHORN RESEARCH INSTITUTE   (Thailand)

^b UNIVERSITY OF CALABAR   (Nigeria)

^c Research and Innovation   (Thailand)

^d MAHIDOL UNIVERSITY   (Thailand)

Author keywords

glucosidase inhibitor; Antiplasmodial; Aromatase inhibitor; Biflavonoid; Garcinia kola; Guttiferae

Indexed keywords

3'',4',4''',5,5'',7,7'' HEPTAHYDROXY 3,8 BIFLAVANONE; ALPHA GLUCOSIDASE INHIBITOR; ANTIMALARIAL AGENT; AROMATASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BARK; BREAST CANCER; DIET SUPPLEMENTATION; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; GARCINIA KOLA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLANT STEM; PROTON NUCLEAR MAGNETIC RESONANCE;

ALPHA-GLUCOSIDASES; ANTIMALARIALS; AROMATASE INHIBITORS; BIFLAVONOIDS; ENZYME INHIBITORS; GARCINIA KOLA; PLANT BARK; PLANT EXTRACTS; PLANT STEMS;

CLUSIACEAE; GARCINIA KOLA;

EID: 77049113531     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1186081     Document Type: Article

References (25)

1. Iwu M M., Igboko O. Flavonoids of Garcinia kola seeds. J Nat Prod 1982 45 650-651
2. Okunji C O., Ware T A., Hicks R P., Iwu M M., Skanchy D J. Capillary electrophoresis determination of biflavanones from Garcinia kola in three traditional African medicinal formulations. Planta Med 2002 68 440-444
3. Hussain R A., Owegby A G., Parimoo P, Waterman P G. Kolanone, a novel polyisoprenylated benzophenone with antimicrobial properties from the fruit of Garcinia kola. Planta Med 1982 44 78-81
4. Han Q B., Lee S F., Qiao C F., He Z D., Song J Z., Sun H D., Xu H X. Complete NMR assignments of the antibacterial biflavonoid GB1 from Garcinia kola. Chem Pharm Bull 2005 53 1034-1036
5. Adaramoye O A., Medeiros I A. Endothelium-independent vasodilation induced by kolaviron, a biflavonoid complex from Garcinia kola seeds, in rat superior mesenteric arteries. J Smooth Muscle Res 2009 45 39-53
6. Farombi E O., Shrotriya S, Surh Y J. Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1. Life Sci 2009 84 149-155
7. Okunji C, Komarnytsky S, Fear G, Poulev A, Ribnicky D M., Awachie P I., Ito Y, Raskin I. Preparative isolation and identification of tyrosinase inhibitors from the seeds of Garcinia kola by high-speed counter-current chromatography. J Chromatogr A 2007 1151 45-50
8. Adaramoye O A., Adeyemi E O. Hepatoprotection of D-galactosamine-induced toxicity in mice by purified fractions from Garcinia kola seeds. Basic Clin Pharmacol Toxicol 2006 98 135-141
9. Adaramoye O A., Adeyemi E O. Hypoglycaemic and hypolipidaemic effects of fractions from kolaviron, a biflavonoid complex from Garcinia kola in streptozotocin-induced diabetes mellitus rats. J Pharm Pharmacol 2006 58 121-128
10. Farombi E O., Nwaokeafor I A. Anti-oxidant mechanisms of kolaviron: studies on serum lipoprotein oxidation, metal chelation and oxidative membrane damage in rats. Clin Exp Pharmacol Physiol 2005 32 667-674
11. Terashima K, Takaya Y, Niwa M. Powerful antioxidative agents based on garcinoic acid from Garcinia kola. Bioorg Med Chem 2002 10 1619-1625
12. Farombi E O., Adepoju B F., Ola-Davies O E., Emerole G O. Chemoprevention of aflatoxin B1-induced genotoxicity and hepatic oxidative damage in rats by kolaviron, a natural bioflavonoid of Garcinia kola seeds. Eur J Cancer Prev 2005 14 207-214
13. Adaramoye O A., Nwaneri V O., Anyanwu K C., Farombi E O., Emerole G O. Possible anti-atherogenic effect of kolaviron (a Garcinia kola seed extract) in hypercholesterolaemic rats. Clin Exp Pharmacol Physiol 2005 32 40-46
14. Tona L, Cimanga R K., Mesia K, Musuamba C T., De Bruyne T, Apers S, Hernans N, Van Miert S, Pieters L, Totté J, Vlietinck A J. In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo. J Ethnopharmacol 2004 93 27-32
15. Braide V B. Antiinflammatory effect of kolaviron, a biflavonoid extract of Garcinia kola. Fitoterapia 1993 64 433-439
16. Gescher A, Gerhäuser C. Cancer chemopreventive agents in plants a continuing challenge. Planta Med 2008 74 1523-1525
17. Francy-Guilford J, Pezzuto J M. Mechanisms of cancer chemopreventive agents: a perspective. Planta Med 2008 74 1644-1650
18. Zimmet P, Alberti K, Shaw J. Global and societal implications of the diabetes epidemic. Nature 2001 414 782-787
19. Paoletta S, Steventon G B., Wildeboer D, Ehrman T M., Hylands P J., Barlow D J. Screening of herbal constituents for aromatase inhibitory activity. Bioorg Med Chem 2008 16 8466-8470
20. Eng E T., Ye J, Williams D, Phung S, Moore R E., Young M K., Gruntmanis U, Braunstein G, Chen S. Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res 2003 63 8516-8522
21. Cuzick J. Aromatase inhibitors for breast cancer prevention. J Clin Oncol 2005 23 1636-1643
22. Iwu M M., Igboko O A., Okunji C O., Tempesta M S. Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola. J Pharm Pharmacol 1990 42 290-292
23. Tabopda T K., Ngoupayo J, Awoussong P K., Mitaine-Offer A C., Ali M S., Ngadjui B T., Lacaille-Dubois M A. Triprenylated flavonoids from Dorstenia psilurus and their alpha-glucosidase inhibition properties. J Nat Prod 2008 71 2068-2072
24. Lee S S., Lin H C., Chen C K. Acylated flavonol monorhamnosides, alpha-glucosidase inhibitors, from Machilus philippinensis. Phytochemistry 2008 69 2347-2353
25. Kawamori R, Tajima N, Iwamoto Y, Kashiwagi A, Shimamoto K, Kaku K. Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. Lancet 2009 373 1607-1614