Controlled dynamization to enhance reconstruction capacity of tissue-engineered bone in healing critically sized bone defects: An in vivo study in goats

Tissue Engineering - Part A

Volumn 16, Issue 1, 2010, Pages 201-212

  Hou, Tianyong ^a,b   Li, Qiang ^a,b,c   Luo, Fei ^a,b   Xu, Jianzhong ^a,b   Xie, Zhao ^a,b   Wu, Xuehui ^a,b   Zhu, Chengling ^a,b  

^a SOUTHWEST HOSPITAL   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

^c NANJING GENERAL HOSPITAL OF NANJING MILITARY COMMAND   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMECHANICS; COMPUTERIZED TOMOGRAPHY; DEFECTS; REPAIR;

AUTOGENOUS BONE; BIOMECHANICAL ANALYSIS; BLOOD SUPPLY; BONE DEFECT; BONE HEALING; BONE IMAGING; BONE REGENERATION; BONE TISSUE; CALLUS FORMATION; CALLUS TISSUE; CARTILAGINOUS TISSUES; COMPUTED TOMOGRAPHY; CONVENTIONAL MODELS; FUNCTIONAL RECOVERY; GOAT MODEL; HISTOLOGICAL OBSERVATIONS; IN-VIVO; OSTEOGENESIS;

BONE;

CAPRA HIRCUS;

ANGIOGENESIS; ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE REGENERATION; CALLUS; CELL DIFFERENTIATION; DISEASE MODEL; FEMUR FRACTURE; FRACTURE HEALING; GOAT; HUMAN; MALE; METABOLISM; ORTHOPEDIC EQUIPMENT; RADIOGRAPHY; TISSUE ENGINEERING; VASCULARIZATION;

ANIMALS; BONE REGENERATION; BONY CALLUS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; FEMORAL FRACTURES; FRACTURE HEALING; GOATS; HUMANS; MALE; NEOVASCULARIZATION, PHYSIOLOGIC; ORTHOPEDIC FIXATION DEVICES; OSTEOGENESIS; TISSUE ENGINEERING;

EID: 77049105230     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0291     Document Type: Article

References (45)

1. Xie, H., Yang, F., Deng, L., Luo, J., Qin, T., Li, X., Zhou, G.Q., and Yang, Z. The performance of a bone-derived scaffold material in the repair of critical bone defects in a rhesus monkey model. Biomaterials 28, 3314, 2007.
2. Viateau, V., Guillemin, G., Bousson, V., Oudina, K., Han-nouche, D., Sedel, L., Logeart-Avramoglou, D., and Petite, H. Long-bone critical-size defects treated with tissue-engineered grafts: a study on sheep. J Orthop Res 25, 741, 2007.
3. Xu, J., Wang, X., Liu, J., Luo, F., Zhou, Q., He, Q.Y., Xie, Z., and Dai, F. A pilot study on the clinical research of TEB repairing long bone defects. Tissue Eng 12, 1125, 2006.
4. Perren, S.M. Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. J Bone Joint Surg Br 84, 1093, 2002.
5. Carter, D.R., Beauprt, G.S., Giori, N.J., and Helms, D.D.S. Mechanobiology of skeletal regeneration. Clin Orthop Relat Res 355, S41, 1998.
6. Claes, L.E., Heigele, C.A., Neidlinger-Wilke, C., Kaspar, D., Seidl, W., Margevicius, K.J., and Augat, P. Effects of mechanical factors on the fracture healing process. Clin Orthop Relat Res 355, S132, 1998.
7. Larsson, S., Kim, W., Caja, V.L., Egger, E.L., Inoue, N., and Chao, E.Y. Effect of early axial dynamization on tibial bone healing: a study in dogs. Clin Orthop Relat Res 388, 240, 2001.
8. Arazi, M., Yalcin, H., Tarakcioglu, N., Dasci, Z., and Kutlu, A. The effects of dynamization and destabilization of the external fixator on fracture healing: a comparative biome-chanical study in dogs. Orthopedics 25, 521, 2002.
9. Bailón-Plaza, A., and van der Meulen, M.C. Beneficial effects of moderate, early loading and adverse effects of delayed or excessive loading on bone healing. J Biomech 36, 1069, 2003.
10. Wolf, S., Augat, P., Eckert-Hü bner, K., Laule, A., Krischak, G.D., and Claes, L.E. Effects of high-frequency, low-magnitude mechanical stimulus on bone healing. Clin Orthop Relat Res 385, 192, 2001.
11. Mauney, J.R., Sjostorm, S., Blumberg, J., Horan, R., O'Leary, J.P., Vunjak-Novakovic, G., Volloch, V., and Kaplan, D.L. Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro. Calcif Tissue Int 74, 458, 2004.
12. Ignatius, A., Blessing, H., Liedert, A., Schmidt, C., Neidlinger-Wilke, C., Kaspar, D., Friemert, B., and Claes, L. Tissue engineering of bone: effects of mechanical strain on osteoblastic cells in type I collagen matrices. Biomaterials 26, 311, 2005.
13. Tanaka, S.M., Li, J., Duncan, R.L., Yokota, H., Burr, D.B., and Turner, C.H. Effects of broad frequency vibration on cultured osteoblasts. J Biomech 36, 73, 2003.
14. Hou, T., Xu, J., Li, Q., Feng, J., and Zen, L. In vitro evaluation of a fibrin gel antibiotic delivery system containing mesen-chymal stem cells and vancomycin alginate beads for treating bone infections and facilitating bone formation. Tissue Eng Part A 14, 1173, 2008.
15. Reddi, A.H., and Huggins, C. Biochemical sequences in the transformation of normal fibroblasts in adolescent rats. Proc Natl Acad Sci USA 69, 1601, 1972.
16. Yang, C.Y., Simmons, D.J., and Lozano, R. The healing of grafts combining freeze-dried and demineralized allogeneic bone in rabbits. Clin Orthop Relat Res 298, 286, 1994.
17. Liu, G., Zhao, L., Zhang, W., Cui, L., Liu, W., and Cao, Y. Repair of goat tibial defects with bone marrow stromal cells and b-tricalcium phosphate. J Mater Sci Mater Med 19, 2367, 2008.
18. Brodt, M.D., Ellis, C.B., and Silva, M.J. Growing C57B1=6 mice increase whole bone mechanical properties by increasing geometric and material properties. J Bone Miner Res 14, 22159, 1999.
19. Lauer, I., Czech, N., Zieron, J., Sieg, P., Richter, E., and Baehre, M. Assessment of the viability of microvascularized bone grafts after mandibular reconstruction by means of bone SPET and semiquantitative analysis. Eur J Nucl Med 27, 1552, 2000.
20. Berding, G., Bothe, K., Gratz, K.F., Schmelzeisen, R., Neu-kam, F.W., and Hundeshagen, H. Bone scintigraphy in the evaluation of bone grafts used for mandibular reconstruction. Eur J Nucl Med 21, 113, 1994.
21. DeCoster, T.A., Gehlert, R.J., Mikola, E.A., and Pirela-Cruz, M.A. Management of posttraumatic segmental bone defects. J Am Acad Orthop Surg 12, 28, 2004.
22. Khan, S.N., Cammisa, F.P., Jr., Sandhu, H.S., Diwan, A.D., Girardi, F.P., and Lane, J.M. The biology of bone grafting. J Am Acad Orthop Surg 13, 77, 2005.
23. Sasso, R.C., LeHuec, J.C., and Shaffrey, C. Spine Interbody Research Group. Iliac crest bone graft donor site pain after anterior lumbar interbody fusion: a prospective patient satisfaction outcome assessment. J Spinal Disord Tech 18, S77, 2005.
24. Silber, J.S., Anderson, D.G., Daffner, S.D., Brislin, B.T., Le-land, J.M., Hilibrand, A.S., Vaccaro, A.R., and Albert, T.J. Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion. Spine 28, 134, 2003.
25. Mistry, A.S., and Mikos, A.G. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol 94, 1, 2005.
26. Mauney, J.R., Jaquiery, C., Volloch, V., Heberer, M., Martin, I., and Kaplan, D.L. In vitro and in vivo evaluation of differentially demineralized cancellous bone scaffolds combined with human bone marrow stromal cells for tissue engineering. Biomaterials 26, 3173, 2005.
27. Zhu, L., Liu, W., Cui, L., and Cao, Y. Tissue-engineered bone repair of goat femur defects with osteogenically induced bone marrow stromal cells. Tissue Eng 12, 423, 2006.
28. Colnot, C., Romero, D.M., Huang, S., and Helms, J.A. Mechanisms of action of demineralized bone matrix in the repair of cortical bone defects. Clin Orthop Relat Res 435, 69, 2005.
29. Kenwright, J., Richardson, J.B., Goodship, A.E., Evans, M., Kelly, D.J., Spriggins, A.J., Newman, J.H., Burrough, S.J., Harris, J.D., and Rowley, D.I. Effect of controlled axial mi-cromovement on healing of tibial fractures. Lancet 2, 1185, 1986.
30. Epari, D.R., Kassi, J.P., Schell, H., and Duda, G.N. Timely fracture-healing requires optimization of axial fixation stability. J Bone Joint Surg Am 89, 1575, 2007.
31. Bishop, N.E., van Rhijn, M., Tami, I., Corveleijn, R., Schneider, E., and Ito, K. Shear does not necessarily inhibit bone healing. Clin Orthop Relat Res 443, 307, 2006.
32. Park, S.H., O'Connor, K., McKellop, H., and Sarmiento, A. The influence of active shear or compressive motion on fracture-healing. J Bone Joint Surg Am 80, 868, 1998.
33. Augat, P., Burger, J., Schorlemmer, S., Henke, T., Peraus, M., and Claes, L. Shear movement at the fracture site delayshealing in a diaphyseal fracture model. J Orthop Res 21, 1011, 2003.
34. Duda, G.N., Sporrer, S., Sollmann, M., Hoffmann, J.E., Kassi, J.P., Khodadadyan, C., and Raschke, M. Interfragmentary movements in the early phase of healing in distraction and correction osteotomies stabilized with ring fixators. Lan-genbecks Arch Chir 387, 433, 2003.
35. Claes, L., Eckert-Hü bner, K., and Augat, P. The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J Orthop Res 20, 1099, 2002.
36. Glowacki, J. Angiogenesis in fracture repair. Clin Orthop Relat Res 355, S82, 1998.
37. Hente, R., Cheal, E.J., and Perren, S.M. Die dehnungstheorie als erklarungsgrundlage des erfolges der biologischen os-teosynthese. Hefte zu Der Unfallchirurg 232, 445, 1992.
38. Augat, P., Margevicius, K., Simon, J., Wolf, S., Suger, G., and Claes, L. Influence of size and stability of the osteotomy gap. J Orthop Res 16, 475, 1998.
39. Nutton, R.W., Fitzgerald, R.H., Jr., and Kelly, P.J. Early dynamic bone-imaging as an indicator of osseous blood flow and factors affecting the uptake of 99mTc hydro-xymethylene diphosphonate in healing bone. J Bone Joint Surg Am 67, 763, 1985.
40. Hamaguchi, H., Fujioka, M., Takahashi, K.A., Hirata, T., Ishida, M., Sakao, K., Ushijima, Y., Kubota, T., Nishimura, T., and Kubo, T. Age-related changes in the hemodynamics of the femoral head as evaluated by early phase of bone scintigraphy. Ann Nucl Med 20, 35, 2006.
41. Kawano, M., Taki, J., Tsuchiya, H., Tomita, K., and Tonami, N. Predicting the outcome of distraction osteogenesis by 3-phase bone scintigraphy. J Nucl Med 44, 369, 2003.
42. Theyse, L.F., Hazewinkel, H.A., Terlou, M., Pollak, Y.W., and Voorhout, G. Evaluation of delayed-image bone scin-tigraphy to assess bone formation after distraction osteo-genesis in dogs. Am J Vet Res 67, 790, 2006.
43. Eski, M., Ilgan, S., Cil, Y., Sengezer, M., Ozcan, A., and Yapici, K. Assessment of distraction regenerate using quantitative bone scintigraphy. Ann Plast Surg 58, 328, 2007.
44. Goodship, A.E., Cunningham, J.L., and Kenwright, J. Strain rate and timing of stimulation in mechanical modulation of fracture healing. Clin Orthop Relat Res 355, S105, 1998.
45. Caplan, A.I. The mesengenic process. Clin Plast Surg 21, 429, 1994.