LRRK2 and Parkin mutations in a family with parkinsonism-Lack of genotype-phenotype correlation

Neurobiology of Aging

Volumn 31, Issue 4, 2010, Pages 721-722

  Marras, Connie ^a,b   Klein, Christine ^a,e   Lang, Anthony E ^a,d   Wakutani, Yosuke ^b   Moreno, Danielle ^b   Sato, Christine ^b   Yip, Edwin ^b   Munhoz, Renato P ^c   Lohmann, Katja ^e   Djarmati, Ana ^e   Bi, Andrew ^b   Rogaeva, Ekaterina ^b,d  

^a TORONTO WESTERN HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c State of Paraná Parkinson's Disease Association   (Brazil)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF LÜBECK   (Germany)

Author keywords

G2019S; LRRK2; Missense mutation; PARK2; Parkin; Parkinson's disease

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; LEVODOPA; PARKIN;

AGED; ARTICLE; CLINICAL ARTICLE; DISEASE COURSE; GENE MUTATION; GENOTYPE PHENOTYPE CORRELATION; HETEROZYGOSITY; HUMAN; ONSET AGE; PARKINSON DISEASE; PARKINSONISM; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ADULT; AGE OF ONSET; AGED; DNA MUTATIONAL ANALYSIS; EPISTASIS, GENETIC; EXONS; FEMALE; GENE DOSAGE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HETEROZYGOTE; HUMANS; INHERITANCE PATTERNS; MALE; MIDDLE AGED; MUTATION; PARKINSONIAN DISORDERS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; UBIQUITIN-PROTEIN LIGASES; YOUNG ADULT;

EID: 77049083850     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2008.05.030     Document Type: Article

References (1)

1. Paisan-Ruiz C., Lang A.E., Kawarai T., Sato C., Salehi-Rad S., Fisman G.K., Al-Khairallah T., St George-Hyslop P., Singleton A., Rogaeva E. LRRK2 gene in Parkinson disease: mutation analysis and case control association study. Neurology 2005, 65:696-700.