Harm and benefits of primary liver resection and salvage transplantation for hepatocellular carcinoma

American Journal of Transplantation

Volumn 10, Issue 3, 2010, Pages 619-627

  Cucchetti, A ^a   Vitale, A ^b   Gaudio, M Del ^a   Ravaioli, M ^a   Ercolani, G ^a   Cescon, M ^a   Zanello, M ^a   Morelli, M C ^a   Cillo, U ^c   Grazi, G L ^a   Pinna, A D ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

Hepatic resection; Hepatocellular carcinoma; Life expectancy; Liver transplantation; Organ allocation

Indexed keywords

ARTICLE; COMPARATIVE STUDY; GRAFT SURVIVAL; HEALTH CARE POLICY; HUMAN; LIFE EXPECTANCY; LIVER CELL CARCINOMA; LIVER RESECTION; LIVER TRANSPLANTATION; PRIORITY JOURNAL; SALVAGE THERAPY; SIMULATION; AGED; CARCINOMA, HEPATOCELLULAR; DONOR; FIBROSIS; LIVER NEOPLASMS; MIDDLE AGED; PROBABILITY; PROCEDURES; STATISTICAL MODEL; TIME; TREATMENT OUTCOME;

AGED; CARCINOMA, HEPATOCELLULAR; FIBROSIS; HEPATECTOMY; HUMANS; LIFE EXPECTANCY; LIVER NEOPLASMS; LIVER TRANSPLANTATION; MARKOV CHAINS; MIDDLE AGED; MODELS, STATISTICAL; SALVAGE THERAPY; TIME FACTORS; TISSUE DONORS; TREATMENT OUTCOME;

EID: 76949104498     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2009.02984.x     Document Type: Article

References (43)

1. El-Serag HB, Davila JA, Petersen NJ, McGlynnn. The continuing increase in the incidence of hepatocellular carcinoma in the United States: An update. Ann Intern Med 2003 139 : 817 823.
2. Thompson Coon J, Rogers G, Hewson P et al. Surveillance of cirrhosis for hepatocellular carcinoma: Systematic review and economic analysis. Health Technol Assess 2007 11 : 1 206.
3. Mazzaferro V, Regalia E, Doci R et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 1996 334 : 693 699.
4. Majno PE, Sarasin FP, Mentha G, Hadengue A. Primary liver resection and salvage transplantation or primary liver transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: An outcome-oriented decision analysis. Hepatology 2000 31 : 899 906.
5. Sherman M. Screening for hepatocellular carcinoma. Hepatol Res 2007 37 (S2) : S152 S165.
6. Trevisani F, De Notaris S, Rapaccini G et al Italian Liver Cancer Group. Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: Effects on cancer stage and patient survival (Italian experience). Am J Gastroenterol 2002 97 : 734 744.
7. Grazi GL, Ercolani G, Pierangeli F et al. Improved results of liver resection for hepatocellular carcinoma on cirrhosis give the procedure added value. Ann Surg 2001 234 : 71 78.
8. Imamura H, Seyama Y, Kokudo N et al. One thousand fifty-six hepatectomies without mortality in 8 years. Arch Surg 2003 138 : 1198 1206.
9. Wiesner RH, Freeman RB, Mulligan DC. Liver transplantation for hepatocellular cancer: The impact of the MELD allocation policy. Gastroenterology 2004 127 (S1 S261 S267.
10. Sharma P, Harper AM, Hernandez JL et al. Reduced priority MELD score for hepatocellular carcinoma does not adversely impact candidate survival awaiting liver transplantation. Am J Transplant 2006 6 : 1957 1962.
11. Volk ML, Vijan S, Marrero JA. A novel model measuring the harm of transplanting hepatocellular carcinoma exceeding Milan criteria. Am J Transplant 2008 8 : 839 846.
12. OPTN. 2007 Annual Report. Available from : http://www.optn.org/data/ annualReport.asp. Accessed June 15, 2009.
13. Freeman RB, Mithoefer A, Ruthazer R et al. Optimizing staging for hepatocellular carcinoma before liver transplantation: A retrospective analysis of the UNOS/OPTN database. Liver Transpl 2006 12 : 1504 1511.
14. UNOS/OPTN. Modifications to policy 3.6.4.4 (Liver candidates with hepatocellular carcinoma). 3.6. Allocation of Livers. Last access on 01 July 2009. Available at : http://www.unos.org/PoliciesandBylaws2/policies/docs/ policy8.doc.
15. Perkins JD, Halldorson JB, Bakthavatsalam R, Fix OK, Carithers RL Jr., Reyes JD. Should liver transplantation in patients with model for end-stage liver disease scores
16. Merion RM, Schaubel DE, Dykstra DM, Freeman RB, Port FK, Wolfe RA. The survival benefit of liver transplantation. Am J Transplant 2005 5 : 307 313.
17. Schaubel DE, Guidinger MK, Biggins SW et al. Survival benefit-based deceased-donor liver allocation. Am J Transplant 2009 9 : 970 981.
18. Guyatt GH, Sackett DL, Sinclair JC, Hayward R, Cook DJ, Cook RJ. Users' guides to the medical literature. IX. A method for grading health care recommendations. Evidence-Based Medicine Working Group. JAMA 1995 274 : 1800 1804.
19. Beck JR, Kassirer JP, Pauker SG. A convenient approximation of life expectancy (the "DEALE"). I. Validation of the method. Am J Med 1982 73 : 883 888.
20. Poon RT, Fan ST, Lo CM, Liu CL, Wong J. Long-term survival and pattern of recurrence after resection of small hepatocellular carcinoma in patients with preserved liver function: Implications for a strategy of salvage transplantation. Ann Surg. 2002 235 : 373 382.
21. Cescon M, Cucchetti A, Grazi GL et al. Indication of the extent of hepatectomy for hepatocellular carcinoma on cirrhosis by a simple algorithm based on preoperative variables. Arch Surg 2009 144 : 57 63.
22. Park YK, Kim BW, Wang HJ, Kim MW. Hepatic resection for hepatocellular carcinoma meeting milan criteria in Child-Turcotte-Pugh class a patients with cirrhosis. Transplant Proc 2009 41 : 1691 1697.
23. D'Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: A systematic review of 118 studies. J Hepatol 2006 44 : 217 231.
24. Lü MD, Kuang M, Liang LJ et al. Surgical resection versus percutaneous thermal ablation for early-stage hepatocellular carcinoma: A randomized clinical trial. Zhonghua Yi Xue Za Zhi 2006 86 : 801 805.
25. Ueno S, Sakoda M, Kubo F et al., Kagoshima Liver Cancer Study Group. Surgical resection versus radiofrequency ablation for small hepatocellular carcinomas within the Milan criteria. J Hepatobiliary Pancreat Surg 2009 16 : 359 366.
26. Tanaka S, Noguchi N, Ochiai T et al. Outcomes and recurrence of initially resectable hepatocellular carcinoma meeting milan criteria: Rationale for partial hepatectomy as first strategy. J Am Coll Surg 2007 204 : 1 6.
27. Adam R, Azoulay D, Castaing D et al. Liver resection as a bridge to transplantation for hepatocellular carcinoma on cirrhosis: A reasonable strategy? Ann Surg 2003 238 : 508 518.
28. Del Gaudio M, Ercolani G, Ravaioli M et al. Liver transplantation for recurrent hepatocellular carcinoma on cirrhosis after liver resection: University of Bologna experience. Am J Transplant 2008 8 : 1177 1185.
29. Margarit C, Escartín A, Castells L, Vargas V, Allende E, Bilbao I. Resection for hepatocellular carcinoma is a good option in Child-Turcotte-Pugh class A patients with cirrhosis who are eligible for liver transplantation. Liver Transpl 2005 11 : 1242 1251.
30. Ikegami T, Shimada M, Imura S et al. The timing of liver transplantation after primary hepatectomy for hepatocellular carcinoma: A special reference to recurrence pattern and Milan criteria. Transplantation 2008 86 : 641 646.
31. Amin MG, Wolf MP, TenBrook JA Jr. et al. Expanded criteria donor grafts for deceased donor liver transplantation under the MELD system: A decision analysis. Liver Transpl 2004 10 : 1468 1475.
32. Sarasin FP, Majno PE, Llovet JM, Bruix J, Mentha G, Hadengue A. Living donor liver transplantation for early hepatocellular carcinoma: A life-expectancy and cost-effectiveness perspective. Hepatology 2001 33 : 1073 1079.
33. Belghiti J, Cortes A, Abdalla EK et al. Resection prior to liver transplantation for hepatocellular carcinoma. Ann Surg 2003 238 : 885 892.
34. Cholongitas E, Marelli L, Shusang V et al. A systematic review of the performance of the model for end-stage liver disease (MELD) in the setting of liver transplantation. Liver Transpl 2006 12 : 1049 1061.
35. Llovet JM, Brú C, Bruix J. Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis 1999 19 : 329 338.
36. Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival. Hepatology 2003 37 : 429 442.
37. Cillo U, Vitale A, Grigoletto F et al. Prospective validation of the Barcelona Clinic Liver Cancer staging system. J Hepatol 2006 44 : 723 731.
38. Wang JH, Changchien CS, Hu TH et al. The efficacy of treatment schedules according to Barcelona Clinic Liver Cancer staging for hepatocellular carcinoma - Survival analysis of 3892 patients. Eur J Cancer 2008 44 : 1000 1006.
39. Bosch FX, Ribes J, Díaz M, Cléries R. Primary liver cancer: Worldwide incidence and trends. Gastroenterology. 2004 127 (S1 S5 S16.
40. Ravaioli M, Grazi GL, Ballardini G et al. Liver transplantation with the Meld system: A prospective study from a single European center. Am J Transplant 2006 6 : 1572 1577.
41. Piscaglia F, Camaggi V, Ravaioli M et al. A new priority policy for patients with hepatocellular carcinoma awaiting liver transplantation within the model for end-stage liver disease system. Liver Transpl 2007 13 : 857 866.
42. Vitale A, Saracino E, D'Amico FE et al. Prospective validation of a new priority allocation model for liver transplant candidates: An interim analysis. Transplant Proc 2009 41 : 1092 1095.
43. Yao FY, Ferrell L, Bass NM, Bacchetti P, Ascher NL, Roberts JP. Liver transplantation for hepatocellular carcinoma: Comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria. Liver Transpl 2002 8 : 765 774.