Pharmacogenomic adaptation of antiretroviral therapy: Overcoming the failure of lopinavir in an African infant with CYP2D6 ultrarapid metabolism

European Journal of Clinical Pharmacology

Volumn 66, Issue 1, 2010, Pages 107-108

  Gorny, Matthias ^a   Röhm, Stephanie ^a   Läer, Stephanie ^a   Morali, Nezihe ^b   Niehues, Tim ^b,c  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^c HELIOS KLINIKUM KREFELD   (Germany)

Author keywords

Antiretroviral therapy; CYP2D6; HAART; Lopinavir; Ritonavir

Indexed keywords

ABACAVIR; CYTOCHROME P450 2D6; LAMIVUDINE; LOPINAVIR; LOPINAVIR PLUS RITONAVIR; NEVIRAPINE; RITONAVIR; VIRUS RNA; ZIDOVUDINE;

AFRICA; CASE REPORT; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG METABOLISM; DRUG RESPONSE; DRUG SUBSTITUTION; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; LETTER; PHARMACOGENOMICS; PRIORITY JOURNAL; TREATMENT FAILURE; VIRUS LOAD;

AFRICAN CONTINENTAL ANCESTRY GROUP; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CYTOCHROME P-450 CYP2D6; DRUG INTERACTIONS; FEMALE; GENOTYPE; HIV INFECTIONS; HUMANS; INFANT; PHARMACOGENETICS; POLYMORPHISM, GENETIC; PYRIMIDINONES; RITONAVIR; TREATMENT FAILURE;

EID: 76949100775     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-009-0753-1     Document Type: Letter

References (5)

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