메뉴 건너뛰기




Volumn 125, Issue 3, 2010, Pages

The novel P2Y12 antagonist AZD6140 rapidly and reversibly reduces platelet activation in diabetic rats

Author keywords

ADP receptors; diabetes; P2Y12; Platelet activation

Indexed keywords

ADENOSINE DIPHOSPHATE; FIBRINOGEN; PADGEM PROTEIN; TICAGRELOR;

EID: 76949091471     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2009.09.025     Document Type: Article
Times cited : (7)

References (42)
  • 1
    • 0033964010 scopus 로고    scopus 로고
    • American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: results from the Third National Health and Nutrition Examination Survey
    • Resnick H.E., Harris M.I., Brock D.B., and Harris T.B. American Diabetes Association diabetes diagnostic criteria, advancing age, and cardiovascular disease risk profiles: results from the Third National Health and Nutrition Examination Survey. Diabetes Care 23 (2000) 176-180
    • (2000) Diabetes Care , vol.23 , pp. 176-180
    • Resnick, H.E.1    Harris, M.I.2    Brock, D.B.3    Harris, T.B.4
  • 2
    • 4143068792 scopus 로고    scopus 로고
    • Diabetes mellitus
    • Michelson A.D. (Ed), Academic Press, San Diego
    • Tschoepe D., and Menart-Houtermans B. Diabetes mellitus. In: Michelson A.D. (Ed). Platelets vol. 29 (2002), Academic Press, San Diego 435-445
    • (2002) Platelets , vol.29 , pp. 435-445
    • Tschoepe, D.1    Menart-Houtermans, B.2
  • 3
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner S.M., Lehto S., Ronnemaa T., Pyorala K., and Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339 (1998) 229-234
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 4
    • 33846414720 scopus 로고    scopus 로고
    • Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
    • Ryden L., Standl E., Bartnik M., Van den B.G., Betteridge J., de Boer M.J., et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 28 (2007) 88-136
    • (2007) Eur Heart J , vol.28 , pp. 88-136
    • Ryden, L.1    Standl, E.2    Bartnik, M.3    Van den, B.G.4    Betteridge, J.5    de Boer, M.J.6
  • 5
    • 0037231665 scopus 로고    scopus 로고
    • Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E
    • Huo Y., Schober A., Forlow S.B., Smith D.F., Hyman M.C., Jung S., et al. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9 (2003) 61-67
    • (2003) Nat Med , vol.9 , pp. 61-67
    • Huo, Y.1    Schober, A.2    Forlow, S.B.3    Smith, D.F.4    Hyman, M.C.5    Jung, S.6
  • 6
    • 0037037566 scopus 로고    scopus 로고
    • A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation
    • Massberg S., Brand K., Gruner S., Page S., Muller E., Muller I., et al. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med 196 (2002) 887-896
    • (2002) J Exp Med , vol.196 , pp. 887-896
    • Massberg, S.1    Brand, K.2    Gruner, S.3    Page, S.4    Muller, E.5    Muller, I.6
  • 7
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • The CAPRIE Steering Committee
    • The CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348 (1996) 1329-1339
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 8
    • 33644872364 scopus 로고    scopus 로고
    • ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention-summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coronary Intervention)
    • Smith Jr. S.C., Feldman T.E., Hirshfeld Jr. J.W., Jacobs A.K., Kern M.J., King III S.B., et al. ACC/AHA/SCAI 2005 guideline update for percutaneous coronary intervention-summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/SCAI Writing Committee to Update the 2001 Guidelines for Percutaneous Coronary Intervention). Circulation 113 (2006) 156-175
    • (2006) Circulation , vol.113 , pp. 156-175
    • Smith Jr., S.C.1    Feldman, T.E.2    Hirshfeld Jr., J.W.3    Jacobs, A.K.4    Kern, M.J.5    King III, S.B.6
  • 9
    • 33846837282 scopus 로고    scopus 로고
    • Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate?
    • Bliden K.P., DiChiara J., Tantry U.S., Bassi A.K., Chaganti S.K., and Gurbel P.A. Increased risk in patients with high platelet aggregation receiving chronic clopidogrel therapy undergoing percutaneous coronary intervention: is the current antiplatelet therapy adequate?. J Am Coll Cardiol 49 (2007) 657-666
    • (2007) J Am Coll Cardiol , vol.49 , pp. 657-666
    • Bliden, K.P.1    DiChiara, J.2    Tantry, U.S.3    Bassi, A.K.4    Chaganti, S.K.5    Gurbel, P.A.6
  • 10
    • 33751572499 scopus 로고    scopus 로고
    • Clopidogrel response variability and future therapies: clopidogrel: does one size fit all?
    • O'Donoghue M., and Wiviott S.D. Clopidogrel response variability and future therapies: clopidogrel: does one size fit all?. Circulation 114 (2006) e600-e606
    • (2006) Circulation , vol.114
    • O'Donoghue, M.1    Wiviott, S.D.2
  • 11
    • 10444281593 scopus 로고    scopus 로고
    • Variable extent of clopidogrel responsiveness in patients after coronary stenting
    • Grossmann R., Sokolova O., Schnurr A., Bonz A., Porsche C., Obergfell A., et al. Variable extent of clopidogrel responsiveness in patients after coronary stenting. Thromb Haemost 92 (2004) 1201-1206
    • (2004) Thromb Haemost , vol.92 , pp. 1201-1206
    • Grossmann, R.1    Sokolova, O.2    Schnurr, A.3    Bonz, A.4    Porsche, C.5    Obergfell, A.6
  • 12
    • 33749438519 scopus 로고    scopus 로고
    • Aspirin and clopidogrel resistance: consideration and management
    • Gurbel P.A., and Tantry U.S. Aspirin and clopidogrel resistance: consideration and management. J Interv Cardiol 19 (2006) 439-448
    • (2006) J Interv Cardiol , vol.19 , pp. 439-448
    • Gurbel, P.A.1    Tantry, U.S.2
  • 13
    • 8344221349 scopus 로고    scopus 로고
    • Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    • Matetzky S., Shenkman B., Guetta V., Shechter M., Bienart R., Goldenberg I., et al. Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction. Circulation 109 (2004) 3171-3175
    • (2004) Circulation , vol.109 , pp. 3171-3175
    • Matetzky, S.1    Shenkman, B.2    Guetta, V.3    Shechter, M.4    Bienart, R.5    Goldenberg, I.6
  • 14
    • 10444235983 scopus 로고    scopus 로고
    • Clopidogrel resistance: a new chapter in a fast-moving story
    • Wiviott S.D., and Antman E.M. Clopidogrel resistance: a new chapter in a fast-moving story. Circulation 109 (2004) 3064-3067
    • (2004) Circulation , vol.109 , pp. 3064-3067
    • Wiviott, S.D.1    Antman, E.M.2
  • 15
    • 8344231455 scopus 로고    scopus 로고
    • Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance
    • Cattaneo M. Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance. Arterioscler Thromb Vasc Biol 24 (2004) 1980-1987
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1980-1987
    • Cattaneo, M.1
  • 16
    • 54949155995 scopus 로고    scopus 로고
    • ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay
    • Schäfer A., Weinberger S., Flierl U., Eigenthaler M., Störk S., Walter U., et al. ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay. Thromb Haemost 100 (2008) 618-625
    • (2008) Thromb Haemost , vol.100 , pp. 618-625
    • Schäfer, A.1    Weinberger, S.2    Flierl, U.3    Eigenthaler, M.4    Störk, S.5    Walter, U.6
  • 17
    • 33847130538 scopus 로고    scopus 로고
    • Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease. Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study
    • Angiolillo D.J., Shoemaker S.B., Desai B., Yuan H., Charlton R.K., Bernardo E., et al. Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease. Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study. Circulation 115 (2007) 708-716
    • (2007) Circulation , vol.115 , pp. 708-716
    • Angiolillo, D.J.1    Shoemaker, S.B.2    Desai, B.3    Yuan, H.4    Charlton, R.K.5    Bernardo, E.6
  • 18
    • 34548841427 scopus 로고    scopus 로고
    • From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
    • Springthorpe B., Bailey A., Barton P., Birkinshaw T.N., Bonnert R.V., Brown R.C., et al. From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis. Bioorg Med Chem Lett 17 (2007) 6013-6018
    • (2007) Bioorg Med Chem Lett , vol.17 , pp. 6013-6018
    • Springthorpe, B.1    Bailey, A.2    Barton, P.3    Birkinshaw, T.N.4    Bonnert, R.V.5    Brown, R.C.6
  • 19
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y(12) antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin
    • Husted S., Emanuelsson H., Heptinstall S., Sandset P.M., Wickens M., and Peters G. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y(12) antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin. Eur Heart J 27 (2006) 1038-1047
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    Sandset, P.M.4    Wickens, M.5    Peters, G.6
  • 20
    • 69249213604 scopus 로고    scopus 로고
    • Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation
    • Van Giezen J.J., Nilsson L., Berntsson P., Wissing B.M., Giordanetto F., Tomlinson W., et al. Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation. J Thromb Haemost 7 (2009) 1556-1565
    • (2009) J Thromb Haemost , vol.7 , pp. 1556-1565
    • Van Giezen, J.J.1    Nilsson, L.2    Berntsson, P.3    Wissing, B.M.4    Giordanetto, F.5    Tomlinson, W.6
  • 21
    • 35548933800 scopus 로고    scopus 로고
    • Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes
    • Storey R.F., Husted S., Harrington R.A., Heptinstall S., Wilcox R.G., Peters G., et al. Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes. J Am Coll Cardiol 50 (2007) 1852-1856
    • (2007) J Am Coll Cardiol , vol.50 , pp. 1852-1856
    • Storey, R.F.1    Husted, S.2    Harrington, R.A.3    Heptinstall, S.4    Wilcox, R.G.5    Peters, G.6
  • 24
    • 13344295095 scopus 로고    scopus 로고
    • Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
    • Savage B., Saldivar E., and Ruggeri Z.M. Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 84 (1996) 289-297
    • (1996) Cell , vol.84 , pp. 289-297
    • Savage, B.1    Saldivar, E.2    Ruggeri, Z.M.3
  • 25
    • 33144479358 scopus 로고    scopus 로고
    • Regulation of platelet functions by P2 receptors
    • Gachet C. Regulation of platelet functions by P2 receptors. Annu Rev Pharmacol Toxicol 46 (2006) 277-300
    • (2006) Annu Rev Pharmacol Toxicol , vol.46 , pp. 277-300
    • Gachet, C.1
  • 26
    • 33747874088 scopus 로고    scopus 로고
    • A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial
    • Montalescot G., Sideris G., Meuleman C., Bal-dit-Sollier C., Lellouche N., Steg P.G., et al. A randomized comparison of high clopidogrel loading doses in patients with non-ST-segment elevation acute coronary syndromes: the ALBION (Assessment of the Best Loading Dose of Clopidogrel to Blunt Platelet Activation, Inflammation and Ongoing Necrosis) trial. J Am Coll Cardiol 48 (2006) 931-938
    • (2006) J Am Coll Cardiol , vol.48 , pp. 931-938
    • Montalescot, G.1    Sideris, G.2    Meuleman, C.3    Bal-dit-Sollier, C.4    Lellouche, N.5    Steg, P.G.6
  • 27
    • 33748948717 scopus 로고    scopus 로고
    • Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting
    • Cuisset T., Frere C., Quilici J., Morange P.E., Nait-Saidi L., Carvajal J., et al. Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting. J Am Coll Cardiol 48 (2006) 1339-1345
    • (2006) J Am Coll Cardiol , vol.48 , pp. 1339-1345
    • Cuisset, T.1    Frere, C.2    Quilici, J.3    Morange, P.E.4    Nait-Saidi, L.5    Carvajal, J.6
  • 28
    • 0038649988 scopus 로고    scopus 로고
    • Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity
    • Gurbel P.A., Bliden K.P., Hiatt B.L., and O'Connor C.M. Clopidogrel for coronary stenting: response variability, drug resistance, and the effect of pretreatment platelet reactivity. Circulation 107 (2003) 2908-2913
    • (2003) Circulation , vol.107 , pp. 2908-2913
    • Gurbel, P.A.1    Bliden, K.P.2    Hiatt, B.L.3    O'Connor, C.M.4
  • 29
    • 34047275256 scopus 로고    scopus 로고
    • The final 10-year follow-up results from the BARI randomized trial
    • The BARI investigators
    • The BARI investigators. The final 10-year follow-up results from the BARI randomized trial. J Am Coll Cardiol 49 (2007) 1600-1606
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1600-1606
  • 30
    • 33846840766 scopus 로고    scopus 로고
    • Coronary heart disease in patients with diabetes: part II: recent advances in coronary revascularization
    • Berry C., Tardif J.C., and Bourassa M.G. Coronary heart disease in patients with diabetes: part II: recent advances in coronary revascularization. J Am Coll Cardiol 49 (2007) 643-656
    • (2007) J Am Coll Cardiol , vol.49 , pp. 643-656
    • Berry, C.1    Tardif, J.C.2    Bourassa, M.G.3
  • 31
    • 62549154026 scopus 로고    scopus 로고
    • Bleeding risk with AZD6140, a reversible P2Y12 receptor antagonist, vs. clopidogrel in patients undergoing coronary artery bypass grafting in the DISPERSE2 trial
    • Husted S., Harrington R.A., Cannon C.P., Storey R.F., Mitchell P., and Emanuelsson H. Bleeding risk with AZD6140, a reversible P2Y12 receptor antagonist, vs. clopidogrel in patients undergoing coronary artery bypass grafting in the DISPERSE2 trial. Int J Clin Pract 63 (2009) 667-670
    • (2009) Int J Clin Pract , vol.63 , pp. 667-670
    • Husted, S.1    Harrington, R.A.2    Cannon, C.P.3    Storey, R.F.4    Mitchell, P.5    Emanuelsson, H.6
  • 32
    • 20144375193 scopus 로고    scopus 로고
    • Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type II
    • Fateh-Moghadam S., Li Z., Ersel S., Reuter T., Htun P., Plöckinger U., et al. Platelet degranulation is associated with progression of intima-media thickness of the common carotid artery in patients with diabetes mellitus type II. Arterioscler Thromb Vasc Biol 25 (2005) 1299-1303
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1299-1303
    • Fateh-Moghadam, S.1    Li, Z.2    Ersel, S.3    Reuter, T.4    Htun, P.5    Plöckinger, U.6
  • 33
    • 33847130538 scopus 로고    scopus 로고
    • Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease. Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study
    • Angiolillo D.J., Shoemaker S.B., Desai B., Yuan H., Charlton R.K., Bernardo E., et al. Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease. Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study. Circulation 115 (2007) 708-716
    • (2007) Circulation , vol.115 , pp. 708-716
    • Angiolillo, D.J.1    Shoemaker, S.B.2    Desai, B.3    Yuan, H.4    Charlton, R.K.5    Bernardo, E.6
  • 34
    • 33847417901 scopus 로고    scopus 로고
    • Late stent thrombosis: considerations and practical advice for the use of drug-eluting stents: a report from the Society for Cardiovascular Angiography and Interventions drug-eluting stent task force
    • Hodgson J., Stone G.W., Lincoff A.M., Klein L., Walpole H., Bottner R., et al. Late stent thrombosis: considerations and practical advice for the use of drug-eluting stents: a report from the Society for Cardiovascular Angiography and Interventions drug-eluting stent task force. Cath Cardiovasc Interv 69 (2007) 327-333
    • (2007) Cath Cardiovasc Interv , vol.69 , pp. 327-333
    • Hodgson, J.1    Stone, G.W.2    Lincoff, A.M.3    Klein, L.4    Walpole, H.5    Bottner, R.6
  • 35
    • 33847741037 scopus 로고    scopus 로고
    • A pooled analysis of data comparing sirolimus-eluting stents with bare-metal stents
    • Spaulding C., Daemen J., Boersma E., Cutlip D.E., and Serruys P.W. A pooled analysis of data comparing sirolimus-eluting stents with bare-metal stents. N Engl J Med 356 (2007) 989-997
    • (2007) N Engl J Med , vol.356 , pp. 989-997
    • Spaulding, C.1    Daemen, J.2    Boersma, E.3    Cutlip, D.E.4    Serruys, P.W.5
  • 36
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators
    • The Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345 (2001) 494-502
    • (2001) N Engl J Med , vol.345 , pp. 494-502
  • 37
    • 0038291914 scopus 로고    scopus 로고
    • Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement
    • Muller I., Besta F., Schulz C., Massberg S., Schonig A., and Gawaz M. Prevalence of clopidogrel non-responders among patients with stable angina pectoris scheduled for elective coronary stent placement. Thromb Haemost 89 (2003) 783-787
    • (2003) Thromb Haemost , vol.89 , pp. 783-787
    • Muller, I.1    Besta, F.2    Schulz, C.3    Massberg, S.4    Schonig, A.5    Gawaz, M.6
  • 38
    • 27644536235 scopus 로고    scopus 로고
    • Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING study
    • Gurbel P.A., Bliden K.P., Guyer K., Cho P.W., Zaman K.A., Kreutz R.P., et al. Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING study. J Am Coll Cardiol 46 (2005) 1820-1826
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1820-1826
    • Gurbel, P.A.1    Bliden, K.P.2    Guyer, K.3    Cho, P.W.4    Zaman, K.A.5    Kreutz, R.P.6
  • 39
    • 33847130538 scopus 로고    scopus 로고
    • Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease. Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study
    • Angiolillo D.J., Shoemaker S.B., Desai B., Yuan H., Charlton R.K., Bernardo E., et al. Randomized Comparison of a High Clopidogrel Maintenance Dose in Patients With Diabetes Mellitus and Coronary Artery Disease. Results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) Study. Circulation 115 (2007) 708-716
    • (2007) Circulation , vol.115 , pp. 708-716
    • Angiolillo, D.J.1    Shoemaker, S.B.2    Desai, B.3    Yuan, H.4    Charlton, R.K.5    Bernardo, E.6
  • 40
    • 27644465874 scopus 로고    scopus 로고
    • Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study
    • Gurbel P.A., Bliden K.P., Samara W., Yoho J.A., Hayes K., Fissha M.Z., et al. Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study. J Am Coll Cardiol 46 (2005) 1827-1832
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1827-1832
    • Gurbel, P.A.1    Bliden, K.P.2    Samara, W.3    Yoho, J.A.4    Hayes, K.5    Fissha, M.Z.6
  • 42
    • 33746291094 scopus 로고    scopus 로고
    • Clinical, biochemical and genetical resistance to clopidogrel in a patient with the recurrent coronary stent thrombosis-a case report and review of the literature
    • Glowczynska R., Malek L.A., Spiewak M., Filipiak K.J., Grabowski M., Kisiel B., et al. Clinical, biochemical and genetical resistance to clopidogrel in a patient with the recurrent coronary stent thrombosis-a case report and review of the literature. Int J Cardiol 111 (2006) 326-328
    • (2006) Int J Cardiol , vol.111 , pp. 326-328
    • Glowczynska, R.1    Malek, L.A.2    Spiewak, M.3    Filipiak, K.J.4    Grabowski, M.5    Kisiel, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.