Low-dose divalproex in agitated patients with Alzheimer's disease

Journal of Psychiatric Practice

Volumn 16, Issue 1, 2010, Pages 63-67

  Dolder, Christian ^a,b   McKinsey, Jonathan ^b  

^a WINGATE UNIVERSITY   (United States)

^b Carolinas Medical Center NorthEast   (United States)

Author keywords

Agitation; Alzheimer's disease; Dementia; Divalproex; Pharmacotherapy

Indexed keywords

BENZODIAZEPINE; MEMANTINE; VALPROATE SEMISODIUM;

AGED; AGITATION; ALZHEIMER DISEASE; ARTICLE; BEDTIME DOSAGE; CLINICAL ARTICLE; DECREASED APPETITE; DEMENTIA; DRUG EFFICACY; DRUG SAFETY; FEMALE; GERONTOPSYCHIATRY; HOSPITAL ADMISSION; HOSPITAL PATIENT; HUMAN; HYPOTENSION; LOW DRUG DOSE; MALE; MORNING DOSAGE; PSYCHIATRIC DEPARTMENT;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANTIMANIC AGENTS; FEMALE; HUMANS; MALE; PSYCHOMOTOR AGITATION; TREATMENT OUTCOME; VALPROIC ACID;

EID: 76849115983     PISSN: 15274160     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pra.0000367781.26507.86     Document Type: Article

References (10)

1. American Psychiatric Association. Practice guideline for the treatment of patients with Alzheimer's disease and other dementias, second edition. October 2007 (available at www.psychiatryonline.com/pracGuide/loadGuidelinePdf.as px?file=AlzPG101007, accessed April 30, 2009).
2. Lyketsos CG, Colenda CC, Beck C, et al. Position statement of the American Association for Geriatric Psychiatry regarding principles of care for patients with dementia resulting from Alzheimer disease. Am J Geriatr Psychiatry 2006;14:561-572
3. Herrmann N, Lanctot KL, Rothenburg LS, et al. A placebocontrolled trial of valproate for agitation and aggression in Alzheimer's disease. Dement Geriatr Cogn Disord 2007;23: 116-119
4. Porsteinsson AP, Tariot PN, Erb R, et al. Placebo-controlled study of divalproex sodium for agitation in dementia. Am J Geriatr Psychiatry 2001;9:58-66.
5. Porsteinsson AP, Tariot PN, Jakimovich LJ, et al. Valproate therapy for agitation in dementia: Open-label extension of a double-blind trial. Am J Geriatr Psychiatry 2003;11: 434-440
6. Sival RC, Duivenvoorden HJ, Jansen PA, et al. Sodium valproate in aggressive behaviour in dementia: A twelve-week open label follow-up study. Int J Geriatr Psychiatry 2004; 19:305-312
7. Sival RC, Haffmans PM, Jansen PA, et al. Sodium valproate in the treatment of aggressive behavior in patients with dementia-A randomized placebo controlled clinical trial. Int J Geriatr Psychiatry 2002;17:579-585
8. Tariot PN, Raman R, Jakimovich L, et al. Divalproex sodium in nursing home residents with possible or probable Alzheimer disease complicated by agitation: A randomized, controlled trial. Am J Geriatr Psychiatry 2005;13: 942-949
9. Birnbaum AK, Ahn JE, Brundage RC, et al. Population pharmacokinetics of valproic acid concentrations in elderly nursing home residents. Ther Drug Monit 2007;29: 571-575
10. Schneider LS, Olin JT, Doody RS, et al. Validity and reliability of the Alzheimer's Disease Cooperative Study- Clinical Global Impression of Change. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 1997;11(suppl 2):S22-32.