Appetite and adverse effects associated with radiation therapy in patients with head and neck cancer

European Journal of Oncology Nursing

Volumn 14, Issue 1, 2010, Pages 3-10

  Ogama, Norimasa ^a   Suzuki, Sumie ^b   Umeshita, Koji ^a   Kobayashi, Tamami ^a   Kaneko, Shoko ^c   Kato, Sakiko ^d   Shimizu, Yasuko ^a  

^a OSAKA UNIVERSITY   (Japan)

^b DOKKYO MEDICAL UNIVERSITY   (Japan)

^c Ibaraki Prefectural Medical Center   (Japan)

^d GUNMA UNIVERSITY   (Japan)

Author keywords

Adverse effects; Appetite; Dysgeusia; Head and neck cancer; Oral mucositis; Radiation therapy; Xerostomia

Indexed keywords

ADJUVANT THERAPY; AGE DISTRIBUTION; AGED; APPETITE; ARTICLE; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; FEMALE; FOLLOW UP; HEAD AND NECK TUMOR; HUMAN; INCIDENCE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROBABILITY; QUALITY OF LIFE; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RADIATION RESPONSE; REGRESSION ANALYSIS; RISK ASSESSMENT; SEX RATIO; STOMATITIS; XEROSTOMIA;

AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; APPETITE; CROSS-SECTIONAL STUDIES; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; FOLLOW-UP STUDIES; HEAD AND NECK NEOPLASMS; HUMANS; INCIDENCE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROBABILITY; QUALITY OF LIFE; RADIATION INJURIES; RADIOTHERAPY DOSAGE; RADIOTHERAPY, ADJUVANT; REGRESSION ANALYSIS; RISK ASSESSMENT; SEX DISTRIBUTION; STOMATITIS; XEROSTOMIA;

EID: 76849094135     PISSN: 14623889     EISSN: 15322122     Source Type: Journal    
DOI: 10.1016/j.ejon.2009.07.004     Document Type: Article

References (31)

1. Anderson D., Hector P., and Linden A. The effects of unilateral and bilateral chewing, empty clenching and simulated bruxism, on the masticatory-parotid salivary reflex in man. Experimental Physiology 81 (1996) 305
2. Appenteng K., Lund P., and Seguin J. Intraoral mechanoreceptor activity during jaw movement in the anesthetized rabbit. Journal of Neurophysiology 48 (1982) 27
3. Alterio D., Jereczek-Fossa A., Fiore R., Piperno G., Ansarin M., and Orecchia R. Cancer treatment-induced oral mucositis. Anticancer Research 27 2 (2007) 1105-1125
4. Bansal M., Mohanti K., Shah N., Chaudhry R., Bahadur S., Shukla K., et al. Radiation related morbidities and their impact on quality of life in head and neck cancer patients receiving radical radiotherapy. Quality of Life Research 13 2 (2004) 481-488
5. Berteretche V., Dalix M., d'Ornano M., Bellisle F., Khayat D., and Faurion A. Decreased taste sensitivity in cancer patients under chemotherapy. Support Care Cancer 12 8 (2004) 571-576
6. Cerchietti C., Navigante H., Bonomi R., Zaderajko A., Menendez R., Pogany E., et al. Pogany CE Effect of topical morphine for mucositis-associated pain following concomitant chemoradiotherapy for head and neck carcinoma. Cancer 95 10 (2002) 2230-2236
7. Denny P. In: Squier C.A., and Hill M.W. (Eds). Salivary Mucins, Aging, and the Oral Mucosal Barrier, in the Effect of Aging in Oral Mucosa and Skin (1994), CRC Press, New York 85
8. Epstein B., Emerton S., Le D., and Stevenson P. A double-blind crossover trial of Oral Balance gel and Biotene toothpaste versus placebo in patients with xerostomia following radiation therapy. Oral Oncology 35 2 (1999) 132-137
9. Haeman K., and Cieslik M. Radiotherapy of head and neck cancers. Wiadomosci lekarskie 61 4-6 (2008) 135-138
10. Hamilton S., Yoo J., Hammond A., Read N., Venkatesan V., Franklin J., et al. Microvascular changes in radiation-induced oral mucositis. Head & Neck Surgery 37 5 (2008) 730-737
11. Hutton L., Baracos E., and Wismer V. Chemosensory dysfunction is a primary factor in the evolution of declining nutritional status and quality of life in patients with advanced cancer. Journal of Pain and Symptom Management 33 2 (2007) 156-165
12. Igarashi, A., Watanabe, M., Nakano, M., Ito, K., Funayama, S., Hitomi, Y., et al., 2006. The taste of saliva in the taste disorder patients (spontaneous abnormal taste sensation) - an Investigation using a taste sensor. Journal of Japanese Association for the Study of Taste and Smell 13 (2), 175-80.
13. Kakinoki Y. The present conditions of dry mouth and the effect of orals wet. Dental Diamond 27 371 (2002) 138-141
14. Kakinoki Y., Nishihara T., Arita M., Shibuya K., and Ishikawa M. Usefulness of new wetness tester for diagnosis of dry mouth in disabled patients. Gerodontology 21 4 (2004) 229-231
15. Kakinoki Y., and Yamada S. Management of Dry Mouth and Oral Health Care for Rehabilitation and Nursing. second ed. (2007), Ishiyaku Publishers, INC., Tokyo p. 95-103
16. Koch M., Patel H., Brennan J., Boyle O., and Sidransky D. Squamous cell carcinoma of the head and neck in the elderly. Archives of Otolaryngology - Head & Neck Surgery 121 3 (1995) 262-265
17. Kuo R., Wu C., Lian L., Ching Y., Lee W., and Juan H. The effects of radiation therapy on salivary function in patient with head and neck cancer. The Kaohsiung Journal of Medical Sciences 9 7 (1993) 401-409
18. Mahood J., Dose M., Loprinzi L., Veeder H., Athmann M., Therneau M., et al. Inhibition of fluorouracil-induced stomatitis by oral cryotherapy. Journal of Clinical Oncology 9 3 (1991) 449-452
19. Mattson E., and Winn M. Smokeless tobacco: association with increased cancer risk. NCI Monographs 8 (1989) 13-16
20. Morton P., Thomson C., Macann A., Gerard M., Izzard M., and Hay D. Home-based humidification for mucositis in patients undergoing radical radiotherapy: preliminary report. Journal of Otolaryngology - Head & Neck Surgery 37 2 (2008) 203-207
21. National Cancer Institute. Common Terminology Criteria for Adverse Event v3.0. Available from: (2006). (accessed 08.09.06)
22. Ogama N., Yoshinaga K., Egawa K., Kitagawa M., Yamamoto K., and Tanaka S. Fundamental study of taste alteration, oral cavity response and characteristics of appetite according to radiation therapy for oral cancer patients. Journal of Japanese Society of Cancer Nursing 20 2 (2006) 51-60
23. Ruo G., and Allis S. Radiotherapy-induced taste impairment. Cancer Treatment Reviews 32 7 (2006) 541-547
24. Sato K., and Kamata R. Quantitative examination of taste deficiency due to radiation therapy. Radiation Medicine 2 1 (1984) 61-70
25. Schwartz K., Weiffenbach M., Valdez H., and Fox C. Taste intensity performance in patients irradiated to the head and neck. Physiology & Behavior 53 4 (1993) 671-677
26. Shih A., Miaskowski C., Dodd J., Stotts A., and MacPhail L. Mechanisms for radiation-induced oral mucositis and the consequences. Cancer Nursing 26 3 (2003) 222-229
27. Sonis T. Perspective on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 100 9 (2004) 1995-2025
28. Tomita H., Ikeda M., and Okuda Y. Basis and practice of clinical taste examinations. Auris, Nasus, Larynx 13 (1986) 1-15
29. Unsal D., Mentes B., Akmansu M., Uner A., Oguz M., and Pak Y. Evaluation of nutritional status in cancer patients receiving radiotherapy: a prospective study. American Journal Of Clinical Oncology 29 2 (2006) 183-188
30. Yamashita H., Nakagawa K., Tago M., Nakamura N., Shiraishi K., Eda M., et al. Taste dysfunction in patients receiving radiotherapy. Head & Neck 28 6 (2006) 508-516
31. Zheng K., Inokuchi A., Yamamoto T., and Komiyama S. Taste dysfunction in irradiated patients with head and neck cancer. FukuokaIgaku Zasshi 93 4 (2002) 64-76