Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Organic Letters

Volumn 12, Issue 4, 2010, Pages 716-719

  Seyedsayamdost, Mohammad R ^a   Chandler, Josephine R ^b   Blodgett, Joshua A V ^a   Lima, Patricia S ^b   Duerkop, Breck A ^b   Oinuma, Ken Ichi ^b   Peter Greenberg, E ^a   Clardy, Jon ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTOBOLIN; BACTOBOLIN D; BENZOPYRAN DERIVATIVE; GAMMA BUTYROLACTONE DERIVATIVE;

ARTICLE; BURKHOLDERIA; CHEMISTRY; GENE EXPRESSION REGULATION; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; QUORUM SENSING;

ACYL-BUTYROLACTONES; ANTI-BACTERIAL AGENTS; BENZOPYRANS; BURKHOLDERIA; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS; QUORUM SENSING;

EID: 76849089925     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol902751x     Document Type: Article

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33. Exogenous bactobolin was added in. the form of filtered culture supernatants of wt B. thailandensis E264, which contained 40 ± 18 μg of bactobolin as quantitated by LC-MS using purified standards.
34. Bactobolin did not accumulate inside the cells of wt or. △btaT B. thailandensis as determined by LC-MS methods (data not shown). The growth kinetics of these two strains were similar with doubling times of 52 ± 1 min and 51 ±2 min, for wt and the btaT mutant, respectively, from two independent measurements (data not shown).
35. The btaK mutant served as a control and abrogated bactobolin. production as anticipated from previous bioassay data (see ref 4).