Beta interferon plus gamma interferon efficiently reduces acyclovir-resistant herpes simplex virus infection in mice in a T-cell-independent manner

Journal of General Virology

Volumn 91, Issue 3, 2010, Pages 591-598

  Huang, Wen Yen ^a   Su, Ying Hsiu ^b   Yao, Hui Wen ^a   Ling, Ping ^c   Tung, Yuk Ying ^a   Chen, Shih Heng ^a   Wang, Xiaohe ^b   Chen, Shun Hua ^a,c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; BETA INTERFERON; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; T LYMPHOCYTE; VIRUS INHIBITION; VIRUS LOAD; VIRUS MUTANT; WILD TYPE;

ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BRAIN STEM; CELL LINE; CORNEA; DRUG RESISTANCE, VIRAL; DRUG THERAPY, COMBINATION; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HUMANS; INTERFERON-BETA; INTERFERON-GAMMA; MICE; MICE, INBRED ICR; MICE, NUDE; T-LYMPHOCYTES; TREATMENT OUTCOME; TRIGEMINAL GANGLION; VIRAL LOAD; VIRUS REPLICATION;

HUMAN HERPESVIRUS 1; MUS; MUS MUSCULUS; SIMPLEXVIRUS;

EID: 76849089520     PISSN: 00221317     EISSN: 14652099     Source Type: Journal    
DOI: 10.1099/vir.0.016964-0     Document Type: Article

References (39)

1. Adler, H., Beland, J. L., Del-Pan, N. C., Kobzik, L., Sobel, R. A. & Rimm, I. J. (1999). In the absence of T cells, natural killer cells protect from mortality due to HSV-1 encephalitis. J Neuroimmunol 93, 208-213.
2. Al-Khatib, K., Williams, B. R., Silverman, R. H., Halford, W. & Carr, D. J. (2004). Distinctive roles for 2′,5′-oligoadenylate synthetases and double-stranded RNA-dependent protein kinase R in the in vivo antiviral effect of an adenoviral vector expressing murine IFN-β. J Immunol 172, 5638-5647.
3. Biron, C. A., Nguyen, K. B., Pien, G. C., Cousens, L. P. & Salazar- Mather, T. P. (1999). Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol 17, 189-220.
4. Casrouge, A., Zhang, S. Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., Alcais, A., Picard, C., Mahfoufi, N. & other authors (2006). Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 314, 308-312.
5. Cheeseman, S. H., Rubin, R. H., Stewart, J. A., Tolkoff-Rubin, N. E., Cosimi, A. B., Cantell, K., Gilbert, J., Winkle, S., Herrin, J. T. & other authors (1979). Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation. Effects on cytomegalovirus and herpes simplex virus infections. N Engl J Med 300, 1345-1349.
6. Chen, S. H., Lin, Y. W., Griffiths, A., Huang, W. Y. & Chen, S. H. (2006a). Competition and complementation between thymidine kinase-negative and wild-type herpes simplex virus during coinfection of mouse trigeminal ganglia. J Gen Virol 87, 3495-3502.
7. Chen, S.H., Yao,H.W., Huang, W. Y.,Hsu,K.S., Lei,H.Y.,Shiau, A. L.& Chen, S. H. (2006b). Efficient reactivation of latent herpes simplex virus from mouse central nervous system tissues. J Virol 80, 12387-12392.
8. Cheng, H., Tumpey, T. M., Staats, H. F., van Rooijen, N., Oakes, J. E. & Lausch, R. N. (2000). Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection. Invest Ophthalmol Vis Sci 41, 1402-1409.
9. - mutants of herpes simplex virus 1. Proc Natl Acad Sci U S A 92, 10516-10520.
10. Christophers, J., Clayton, J., Craske, J., Ward, R., Collins, P., Trowbridge, M. & Darby, G. (1998). Survey of resistance of herpes simplex virus to acyclovir in northwest England. Antimicrob Agents Chemother 42, 868-872.
11. Coen, D. M. & Schaffer, P. A. (2003). Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets. Nat Rev Drug Discov 2, 278-288.
12. Coen, D. M., Kosz-Vnenchak, M., Jacobson, J. G., Leib, D. A., Bogard, C. L., Schaffer, P. A., Tyler, K. L. & Knipe, D. M. (1989). Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proc Natl Acad Sci U S A 86, 4736-4740.
13. Corey, L., Whitley, R. J., Stone, E. F. & Mohan, K. (1988). Difference between herpes simplex virus type 1 and type 2 neonatal encephalitis in neurological outcome. Lancet 1, 1-4.
14. Davar, G., Kramer, M. F., Garber, D., Roca, A. L., Andersen, J. K., Bebrin, W., Coen, D. M., Kosz-Vnenchak, M., Knipe, D. M. & other authors (1994). Comparative efficacy of expression of genes delivered to mouse sensory neurons with herpes virus vectors. J Comp Neurol 339, 3-11.
15. Dienstag, J. L. (2008). Hepatitis B virus infection. N Engl J Med 359, 1486-1500.
16. Fleming, H. E. & Coen, D. M. (1984). Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin. Antimicrob Agents Chemother 26, 382-387.
17. Griffiths, A., Chen, S. H., Horsburgh, B. C. & Coen, D. M. (2003). Translational compensation of a frameshift mutation affecting herpes simplex virus thymidine kinase is sufficient to permit reactivation from latency. J Virol 77, 4703-4709.
18. Hoofnagle, J. H. & di Bisceglie, A. M. (1997). The treatment of chronic viral hepatitis. N Engl J Med 336, 347-356.
19. Horsburgh, B. C., Chen, S. H., Hu, A., Mulamba, G. B., Burns, W. H. & Coen, D. M. (1998). Recurrent acyclovir-resistant herpes simplex in an immunocompromised patient: can strain differences compensate for loss of thymidine kinase in pathogenesis? J Infect Dis 178, 618-625.
20. Kassim, S. H., Rajasagi, N. K., Zhao, X., Chervenak, R. & Jennings, S. R. (2006). In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses. J Virol 80, 3985-3993.
21. Larkin, J., Jin, L., Farmen, M., Venable, D., Huang, Y., Tan, S. L. & Glass, J. I. (2003). Synergistic antiviral activity of human interferon combinations in the hepatitis C virus replicon system. J Interferon Cytokine Res 23, 247-257.
22. Le Bon, A. & Tough, D. F. (2002). Links between innate and adaptive immunity via type I interferon. Curr Opin Immunol 14, 432-436.
23. Mossman,K. L.,Saffran, H. A. & Smiley, J.R. (2000). Herpes simplex virus ICP0 mutants are hypersensitive to interferon. J Virol 74, 2052-2056.
24. Pazin, G. J., Armstrong, J. A., Lam, M. T., Tarr, G. C., Jannetta, P. J. & Ho, M. (1979). Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root. N Engl J Med 301, 225-230.
25. Pelosi, E., Rozenberg, F., Coen, D. M. & Tyler, K. L. (1998). A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology 252, 364-372.
26. Peng, T., Zhu, J., Hwangbo, Y., Corey, L. & Bumgarner, R. E. (2008). Independent and cooperative antiviral actions of beta interferon and gamma interferon against herpes simplex virus replication in primary human fibroblasts. J Virol 82, 1934-1945.
27. Roizman, B., Knipe, D. M. & Whitley, R. J. (2007). Herpes simplex viruses. In Fields Virology, 5th edn, pp. 2501-2601. Edited by D. M. Knipe & P. Howley. Philadelphia: Lippincott Williams & Wilkins.
28. Sainz, B., Jr & Halford, W. P. (2002). Alpha/beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1. J Virol 76, 11541-11550.
29. Sainz, B., Jr, Mossel, E. C., Peters, C. J. & Garry, R. F. (2004). Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated corona-virus (SARS-CoV). Virology 329, 11-17.
30. Sainz, B., Jr, LaMarca, H. L., Garry, R. F. & Morris, C. A. (2005). Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma. Virol J 2, 14-26.
31. Schoenborn, J. R. & Wilson, C. B. (2007). Regulation of interferon-γ during innate and adaptive immune responses. Adv Immunol 96, 41-101.
32. + cells. J Virol 65, 6008-6014.
33. Stanberry, L.R., Jorgensen, D. M. & Nahmias, A. J. (1997). Herpes simplex viruses 1 and 2. In Viral Infections of Humans: Epidemiology and Control, pp. 419-454. Edited by A. S. Evans & R. A. Kaslow. New York: Springer.
34. Stranska, R., van Loon, A. M., Polman, M., Beersma, M. F., Bredius, R. G., Lankester, A. C., Meijer, E. & Schuurman, R. (2004). Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients. Antivir Ther 9, 565-575.
35. Tenser, R. B. & Edris, W. A. (1987). Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus after in vivo complementation. J Virol 61, 2171-2174.
36. Virelizier, J. L. & Arenzana-Seisdedos, F. (1985). Immunological functions of macrophages and their regulation by interferons. Med Biol 63, 149-159.
37. Wang, K., Mahalingam, G., Hoover, S. E., Mont, E. K., Holland, S. M., Cohen, J. I. & Straus, S. E. (2007). Diverse herpes simplex virus type 1 thymidine kinase mutants in individual human neurons and ganglia. J Virol 81, 6817-6826.
38. Whitley, R. J. (2002). Herpes simplex virus infection. Semin Pediatr Infect Dis 13, 6-11.
39. Zhang, S. Y., Jouanguy, E., Ugolini, S., Smahi, A., Elain, G., Romero, P., Segal, D., Sancho-Shimizu, V., Lorenzo, L. & other authors (2007). TLR3 deficiency in patients with herpes simplex encephalitis. Science 317, 1522-1527.