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Volumn 396, Issue 3, 2010, Pages 1249-1257

Determination of naltrexone and 6β-naltrexol in human blood: Comparison of high-performance liquid chromatography with spectrophotometric and tandem-mass-spectrometric detection

(8) Brünen, Sonja a Krüger, Ralf a Finger, Susann a Korf, Felix a Kiefer, Falk b Wiedemann, Klaus c Lackner, Karl J a Hiemke, Christoph a

a JOHANNES GUTENBERG UNIVERSITY (Germany)

b UNIVERSITY OF HEIDELBERG (Germany)

c UNIVERSITY OF HAMBURG (Germany)

Author keywords

6 Naltrexol; High performance liquid chromatography UV detection; Liquid chromatography tandem mass spectrometry; Naltrexone; Therapeutic drug monitoring

Indexed keywords

BLOOD SERUM; CALIBRATION CURVES; CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC SEPARATIONS; COLUMN SWITCHING; CORRELATION COEFFICIENT; HPLC/UV; HUMAN BLOODS; INTERNAL STANDARDS; LC-MS/MS; LIMIT OF QUANTIFICATIONS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MASS SPECTROMETRIC DETECTION; NALTREXONE; PERFECT BOND; PROTEIN PRECIPITATION; SAMPLE CLEAN-UP; TANDEM MASS SPECTROMETRY; TETRAMETHYLETHYLENEDIAMINE; THERAPEUTIC DRUG MONITORING; UV DETECTION; UV SPECTROPHOTOMETRIC DETECTION;

ACETONITRILE; BLOOD; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DEIONIZED WATER; DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; ISOMERS; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; ORGANIC ACIDS; PATIENT MONITORING; PRECIPITATION (CHEMICAL); SPECTROPHOTOMETERS; SPECTROPHOTOMETRY;

LIQUIDS;

6 BETA HYDROXYNALTREXONE; 6 BETA-HYDROXYNALTREXONE; DRUG DERIVATIVE; NALTREXONE;

ARTICLE; BLOOD; COMPARATIVE STUDY; ECONOMICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METHODOLOGY; SPECTROPHOTOMETRY; STATISTICAL PARAMETERS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LIMIT OF DETECTION; NALTREXONE; SPECTROPHOTOMETRY; TANDEM MASS SPECTROMETRY;

EID: 76749171212 PISSN: 16182642 EISSN: 16182650 Source Type: Journal
DOI: 10.1007/s00216-009-3301-z Document Type: Article

Times cited : (12)

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