Effect of caloric restriction on base-excision repair (BER) in the aging rat brain

Experimental Gerontology

Volumn 45, Issue 3, 2010, Pages 208-216

  Kisby, Glen E ^a   Kohama, Steven G ^b   Olivas, Antoinette ^a   Churchwell, Mona ^c   Doerge, Daniel ^c   Spangler, Edward ^d   Cabo, Rafael de ^d   Ingram, Donald K ^d   Imhof, Barry ^e   Bao, Gaobin ^e   Kow, Yoke W ^e  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

8 Oxodeoxyguanosine; Apyrimidinic apurinic endonuclease (APE); DNA ligase III; DNA polymerase ; Exonuclease; Frontal parietal cortex

Indexed keywords

DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA DIRECTED DNA POLYMERASE BETA; DNA LIGASE III; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CALORIC RESTRICTION; CEREBELLUM; CONTROLLED STUDY; ENZYME ACTIVITY; EXCISION REPAIR; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; LIFE EXTENSION; MALE; MESENCEPHALON; NONHUMAN; OXIDATIVE STRESS; PARIETAL LOBE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RAT; TISSUE DISTRIBUTION;

AGED; AGING; ANIMALS; BODY WEIGHT; BRAIN; CALORIC RESTRICTION; DNA DAMAGE; DNA REPAIR; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HUMANS; MACACA MULATTA; MALE; OXIDATION-REDUCTION; RATS; RATS, INBRED F344;

ANIMALIA; RATTUS;

EID: 76749165751     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2009.12.003     Document Type: Article

References (48)

1. Barja G. Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism?. Biol. Rev. Camb. Philos. Soc. 79 (2004) 235-251
2. Barja G. Free radicals and aging. Trends Neurosci. 27 (2004) 595-600
3. Barzilay G., Walker L.J., Rothwell D.G., and Hickson I.D. Role of the HAP1 protein in repair of oxidative DNA damage and regulation of transcription factors. Br. J. Cancer 74 (1996) S145-S150
4. Bordone L., and Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell. Biol. 6 (2005) 298-305
5. Butterfield D.A., and Poon H.F. The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease. Exp. Gerontol. 40 (2005) 774-783
6. Cabelof D.C., Yanamadala S., Raffoul J.J., Guo Z., Soofi A., and Heydari A.R. Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline. DNA Repair (Amst) 2 (2003) 295-307
7. Cadet J., Bourdat A.G., D'Ham C., Duarte V., Gasparutto D., Romieu A., and Ravanat J.L. Oxidative base damage to DNA: specificity of base excision repair enzymes. Mutat. Res. 462 (2000) 121-128
8. Cardozo-Pelaez F., Brooks P.J., Stedeford T., Song S., and Sanchez-Ramos J. DNA damage, repair, and antioxidant systems in brain regions: a correlative study. Free Radical Biol. Med. 28 (2000) 779-785
9. Cardozo-Pelaez F., Song S., Parthasarathy A., Hazzi C., Naidu K., and Sanchez-Ramos J. Oxidative DNA damage in the aging mouse brain. Mov. Dis. 14 (1999) 972-980
10. Chen D., Cao G., Hastings T., Feng Y., Pei W., O'Horo C., and Chen J. Age-dependent decline of DNA repair activity for oxidative lesions in rat brain mitochondria. J. Neurochem. 81 (2002) 1273-1284
11. Choi J.Y., Kim H.S., Kang H.K., Lee D.W., Choi E.M., and Chung M.H. Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radical Biol. Med. 27 (1999) 848-854
12. Churchwell M.I., Beland F.A., and Doerge D.R. Quantification of multiple DNA adducts formed through oxidative stress using liquid chromatography and electrospray tandem mass spectrometry. Chem. Res. Toxicol. 15 (2002) 1295-1301
13. de Boer J., Andressoo J.O., de Wit J., Huijmans J., Beems R.B., van Steeg H., Weeda G., van der Horst G.T., van Leeuwen W., Themmen A.P., Meradji M., and Hoeijmakers J.H. Premature aging in mice deficient in DNA repair and transcription. Science 296 (2002) 1276-1279
14. Duguid J.R., Eble J.N., Wilson T.M., and Kelley M.R. Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme. Cancer Res. 55 (1995) 6097-6102
15. Gredilla, R., Garm, C., Holm, R., Bohr, V.A. and Stevnsner, T., in press. Differential age-related changes in mitochondrial DNA repair activities in mouse brain regions. Neurobiol. Aging.
16. Guo Z., Heydari A., and Richardson A. Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes: effect of age and dietary restriction. Exp. Cell Res. 245 (1998) 228-238
17. Hamilton M.L., Van Remmen H., Drake J.A., Yang H., Guo Z.M., Kewitt K., Walter C.A., and Richardson A. Does oxidative damage to DNA increase with age?. Proc. Natl. Acad. Sci. USA 98 (2001) 10469-10474
18. Harrison J.F., Hollensworth S.B., Spitz D.R., Copeland W.C., Wilson G.L., and LeDoux S.P. Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance. Nucleic Acids Res. 33 (2005) 4660-4671
19. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., and Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 299 (2003) 1355-1359
20. Heydari A.R., Unnikrishnan A., Lucente L.V., and Richardson A. Caloric restriction and genomic stability. Nucleic Acids Res. 35 (2007) 7485-7496
21. Hiona A., and Leeuwenburgh C. Effects of age and caloric restriction on brain neuronal cell death/survival. Ann. N. Y. Acad. Sci. 1019 (2004) 96-105
22. Holmes G.E., Bernstein C., and Bernstein H. Oxidative and other DNA damages as the basis of aging: a review. Mutat. Res. 275 (1992) 305-315
23. Hosokawa M., Fujisawa H., Ax S., Zahn-Daimler G., and Zahn R.A. Age-associated DNA damage is accelerated in the senescence-accelerated mice. Mech. Ageing Dev. 118 (2000) 61-70
24. Imam S.Z., Karahalil B., Hogue B.A., Souza-Pinto N.C., and Bohr V.A. Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner. Neurobiol. Aging 27 (2006) 1129-1136
25. Izumi T., Brown D.B., Naidu C.V., Bhakat K.K., Macinnes M.A., Saito H., Chen D.J., and Mitra S. Two essential but distinct functions of the mammalian abasic endonuclease. Proc. Natl. Acad. Sci. USA 102 (2005) 5739-5743
26. Izumi T., Henner W.D., and Mitra S. Negative regulation of the major human AP-endonuclease, a multifunctional protein. Biochemistry 35 (1996) 14679-14683
27. Kisby G.E., Milne J., and Sweatt C. Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue. NeuroReport 8 (1997) 1337-1340
28. Koubova J., and Guarente L. How does calorie restriction work?. Genes Dev. 17 (2003) 313-321
29. Krishna T.H., Hemkal A., and Rao K.S. The presence of 3′-5′ exonuclease activity in rat brain neurons and its role in template-driven extension of 3′-mismatched primers by DNA-polymerase beta in aging neurons. Neurochem. Res. 29 (2004) 761-770
30. Lopez-Lluch G., Hunt N., Jones B., Zhu M., Jamieson H., Hilmer S., Cascajo M.V., Allard J., Ingram D.K., Navas P., and de Cabo R. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency. Proc. Natl. Acad. Sci. USA 103 (2006) 1768-1773
31. Lu T., Pan Y., Kao S.Y., Li C., Kohane I., Chan J., and Yankner B.A. Gene regulation and DNA damage in the ageing human brain. Nature 24 (2004) 883-891
32. Markesbery W.R. Oxidative stress hypothesis in Alzheimer's disease. Free Rad. Biol. Med. 23 (1997) 134-147
33. Mattson M.P., Duan W., Lee J., and Guo Z. Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms. Mech. Ageing Dev. 122 (2001) 757-778
34. Maynard S., Schurman S.H., Harboe C., de Souza-Pinto N.C., and Bohr V.A. Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis 30 (2009) 2-10
35. Muniz J.F., McCauley L., Scherer J., Lasarev M., Koshy M., Kow Y.W., Nazar-Stewart V., and Kisby G.E. Biomarkers of oxidative stress and DNA damage in agricultural workers: a pilot study. Toxicol. Appl. Pharmacol. 227 (2008) 97-107
36. Nishikawa T., Takahashi J.A., Fujibayashi Y., Fujisawa H., Zhu B., Nishimura Y., Ohnishi K., Higuchi K., Hashimoto N., and Hosokawa M. An early stage mechanism of the age-associated mitochondrial dysfunction in the brain of SAMP8 mice; an age-associated neurodegeneration animal model. Neurosci. Lett. 254 (1998) 69-72
37. Ono Y., Furuta T., Ohmoto T., Akiyama K., and Seki S. Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease. Mutat. Res. 315 (1994) 55-63
38. Prapurna D.R., and Rao K.S. Long-term effects of caloric restriction initiated at different ages on DNA polymerases in rat brain. Mech. Ageing Dev. 92 (1996) 133-142
39. Rattan S.I. Hormesis in aging. Ageing Res. Rev. 7 (2008) 63-78
40. Rehman A., Nourooz-Zadeh J., Moller W., Tritschler H., Pereira P., and Halliwell B. Increased oxidative damage to all DNA bases in patients with type II diabetes mellitus. FEBS Lett. 448 (1999) 120-122
41. Retel J., Hoebee B., Braun J.E.F., Lutgerink J.T., van den Akker E., Wanamarta A.H., Joenje H., and Lafleur M.V.M. Mutational specificity of oxidative DNA damage. Mutat. Res. 299 (1993) 165-182
42. Stuart J.A., Karahalil B., Hogue B.A., Souza-Pinto N.C., and Bohr V.A. Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction. FASEB J. 18 (2004) 595-597
43. Szczesny B., Bhakat K.K., Mitra S., and Boldogh I. Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution. Mech. Ageing Dev. 125 (2004) 755-765
44. Tell G., Crivellato E., Pines A., Paron I., Pucillo C., Manzini G., Bandiera A., Kelley M.R., Loreto C.D., and Damante G. Mitochondrial localization of APE/Ref-1 in thyroid cells. Mutat. Res. 485 (2001) 143-152
45. Tell G., Damante G., Caldwell D., and Kelley M.R. The intracellular localization of APE1/Ref-1: more than a passive phenomenon?. Antioxid. Redox. Signal. 7 (2005) 367-384
46. Tomkinson A.E., Bonk R.T., and Linn S. Mitochondrial endonuclease activities specific for apurinic/apyrimidinic sites in DNA from mouse cells. J. Biol. Chem. 263 (1988) 12532-12537
47. Vasko M.R., Guo C., and Kelley M.R. The multifunctional DNA repair/redox enzyme Ape1/Ref-1 promotes survival of neurons after oxidative stress. DNA Repair 4 (2005) 367-379
48. Wang J., Xiong S., Xie C., Markesbery W.R., and Lovell M.A. Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease. J. Neurochem. 93 (2005) 953-962