Comparative evaluation of phenol and thimerosal as preservatives for a candidate vaccine against American cutaneous leishmaniasis

Memorias do Instituto Oswaldo Cruz

Volumn 105, Issue 1, 2010, Pages 86-91

  Mayrink, Wilson ^a   Tavares, Carlos Alberto Pereira ^a   de Deus, Rosangela Barbosa ^a   Pinheiro, Melina Barros ^b   Guimarães, Tânia Mara Pinto Dabés ^b   de Andrade, Hélida Monteiro ^a   da Costa, Carlos Alberto ^b   de Toledo, Vicente de Paulo Coelho Peixoto ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

Author keywords

Candidate vaccine; Leishmaniasis; Merthiolate; Phenol

Indexed keywords

ANIMALIA; LEISHMANIA AMAZONENSIS; MUS;

EID: 76749162919     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762010000100013     Document Type: Article

References (26)

1. Amaral VF, Teva A, Oliveira-Neto MP, Silva AJ, Pereira MS, Cupolillo E, Porrozzi R, Coutinho SG, Pirmez C, Beverly SM, Grimaldi GJr 2002. Study of the safety, immunogenicity and efficacy of attenuated and killed Leishmania (Leishmania) major vaccines in a rhesus monkey (Macaca mulatta) model of the human disease. Mem Inst Oswaldo Cruz 97: 1041-1048.
2. Antunes CMF, Mayrink W, Magalhães PA, Costa CA da, Melo MN, Dias M, Michalick MSM, Williams P, Oliveira-Lima A, Vieira JBF, Schettini APM 1986. Controlled field trials of a vaccine against new cutaneous leishmaniasis. Int J Epidemiol 15: 147-154.
3. Armijos RX, Weigel MM, Aviles H, Maldonado R, Racines J 1998. Field trial of a vaccine against New World cutaneous leishmaniasis in an at-risk child population: safety, immunogenicity and efficacy during the first 12 months of follow-up. J Infect Dis 177: 1352-1357.
4. Armijos RX, Weigel MM, Calvopina M, Hidalgo A, Cevallos W, Correa J 2004. Safety, immunogenicity and efficacy of an autoclaved Leishmania amazonensis vaccine plus BCG adjuvant against New World cutaneous leishmaniasis. Vaccine 22: 1320-1326.
5. Convit JO, Castellanos PIO, Rondon AO, Pinardi MEO, Ulrich MO, Castes M 1987. Immunotherapy versus chemotherapy in localised cutaneous leishmaniasis. Lancet 1: 401-405.
6. Convit JO, Ulrich MO, Zerpa OO, Borges RO, Aranzazu NO, Valera MO, Villarroel HO, Zapata Z, Tomedes I 2003. Immunotherapy of American cutaneous leishmaniasis in Venezuela during the period 1990-1999. Trans R Soc Trop Med Hyg 97: 469-472.
7. Costa CA da, Afonso LCC, Toledo VPCP, Guimarães TMPD, Nascimento E, Tavares CAP, Mayrink W 1992. Immune responses and protection induced in mice by an industrialized vaccine against American cutaneous leishmaniasis. Parassitologia 34: 45-51.
8. Costa CA da, Toledo VPCP, Genaro O, Williams P, Mayrink W 1996. Montenegro skin test evaluation of the composition and stability of the antigen preparation. Mem Inst Oswaldo Cruz 91: 193-194.
9. De Luca PM, Mayrink W, Alves CR, Coutinho SG, Oliveira MP, Bertho AL, Toledo VPCP, Costa CA, Genaro O, Mendonça SC 1999. Evaluation of the stability and immunogenicity of autoclaved and non autoclaved preparations of a vaccine against American tegumentary leishmaniasis. Vaccine 17: 1179-1185.
10. Erlanger BF, Kokowsky N, Cohen W 1961. The preparation and properties of two new chromogenic substrates of trypsin. Arch Biochem Biophys 95: 271-278.
11. Geier DA, Sykes LK, Geier MR 2007. A review of thimerosal (merthiolate) and its ethylmercury breakdown product: specific historical considerations regarding safety and effectiveness. J Toxicol Environ Health B Crit Rev 10: 575-596.
12. Khamesipour A, Rafati S, Davoudi N, Maboudi F, Modabber F 2006. Leishmaniasis vaccine for development: a global overview. Indian J Med Res 123: 423-438.
13. Laemmli UK 1970. Cleavage of structural protein. The assembly of the head of bacteriophage T4. Nature 27: 680-685.
14. Machado-Pinto J, Pinto J, da Costa CA, Genaro O, Marques MJ, Modabber F, Mayrink W 2002. Immunochemotherapy for cutaneous Leishmaniasis: a controlled trial using killed Leishmania (Leishmania) amazonensis vaccine plus antimonial. Int J Dermatol 41: 73-78.
15. Mayrink W, Costa CA da, Magalhães PA 1979. A field trial of a vaccine against American dermal leishmaniasis. Trans R Soc Trop Med Hyg 73: 385-387.
16. Mayrink W, Machado-Coelho GLL, Guimarães TMPD, Andrade HM, Perez EC, Costa CA da, Toledo VPCP 2006. Immuno-biochemical evaluations of phenol and merthiolate as antigens preservatives in Montenegro skin test. Acta Trop 98: 87-93.
17. Mayrink W, Magalhães PA, Dias M, Costa CA da, Melo MN, Oliveira-Lima A 1978. Responses to Montenegro antigen after immunization with killed Leishmania promastigotes. Trans R Soc Trop Med Hyg 72: 676.
18. Mendonça SC, Coutinho SG, Amendoeira RR, Marzochi MC, Pirmez C 1986. Human American cutaneous leishmaniasis (Leishmania b. braziliensis) in Brazil: lymphoproliferative responses and influence of therapy. Clin Exp Immunol 64: 269-276.
19. Mendonça SCF, De Luca PM, Mayrink W, Restom TG, Conceição-Silva F, da-Cruz AM, Bertho AL, Costa CA da, Genaro O, Toledo VPCP, Coutinho SG 1995. Characterization of the human T lymphocyte-mediate immune response induced by a vaccine against American tegumentary leishmaniasis. Am J Trop Med Hyg 53: 195-201.
20. Merril CR, Goldman D, Sedman SA, Ebert MH 1981. Ultrasensitive strain for proteins in polyacrilamide gels shows regional variation in cerebrospinal fluid proteins. Science 211: 1437-1438.
21. Musa AM, Khalil EA, Mahgoub FA, Elgawi SH, Modabber FO, Elkadaru AE 2008. Immunochemotherapy of persistent post-kalaazar dermal leishmaniasis: a novel approach to treatment. Trans R Soc Trop Med Hyg 102: 58-63.
22. Nascimento E, Mayrink W, Costa CA da, Michalick MSM, Melo MN, Barros GC, Dias M, Antunes CMF, Lima MS, Taboada DC, Liu TY 1990. Vaccination of humans against cutaneous leishmaniasis: cellular and humoral immune responses. Infect Immun 58: 2198-2203.
23. Noazin S, Moddaber F, Khamesipour A, Smith PS, Moulton LH, Nasseri K, Sharifi I, Khalil EAG, Bernal IDV, Antunes CMF, Kieny MP, Tanner M 2008. First generation leishmaniasis vaccines: a review of field efficacy trials. Vaccine 26: 6759-6767.
24. Sinha PK, Pandey K, Bhattacharya SK 2005. Diagnosis & management of Leishmania/HIV co-infection. Indian J Med Res 121: 407-414.
25. WHO 1981. Report of Expert Committee on Biological Standartization. Requirements for meningococcal vaccine. Technical Report Series 658. Available from: www.who.int/biologicals/publications/trs/areas/en/
26. WHO 2002. Control of the leishmaniasis: report of a WHO Expert Committee. Report Series 793. Available from: www.who.int/biologicals/publications/trs/areas/en/