Effect of purified saponin mixture from astragalus corniculatus on toxicity models in isolated rat hepatocytes

Pharmaceutical Biology

Volumn 46, Issue 12, 2008, Pages 866-870

  Mitcheva, Mitka ^a   Kondeva Burdina, Magdalena ^a   Vitcheva, Vessela ^a   Krasteva, Ilina ^a   Nikolov, Stefan ^a  

^a MEDICAL UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Astragalus corniculatus; carbon tetrachloride toxicity; cell viability; Isolated hepatocytes; saponins; tert butyl hydroperoxide toxicity

Indexed keywords

EID: 76749153122     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200802367247     Document Type: Article

References (18)

1. Bae Jin HA, Lee JY (2003): The effect of chondroitin sulfate against CCl4-induced hepatotoxicity. Biol Pharm Bull 26: 622-626. (Pubitemid 39663552)
2. Fau D, Berson A, Eugene D, Fromenty B, Fisch C, Pessayre D (1992): Mechanism for the hepatotoxicity of the antiandrogen, nilutamide. Evidence suggesting that redox cycling of this nitroaromatic drug leads to oxidative stress in isolated hepatocytes. J Pharm Exp Ther 263: 69-77.
3. Ferreira M, Nunes O, Leal L, Pessoa O, Lemos T, Viana G (2003): Antioxidant effects in the quinine fraction from Auxemma oncocalyx Taub. Biol Pharm Bull 26: 595-599. (Pubitemid 39663547)
4. Hong C, Lo YC, Tan FC, Wei YH, Chen CF (1994): Astragalus membranaceus and Polygonum multiflorum protect rat heart mitochondria against lipid peroxidation. Am J Chin Med 22: 63-70.
5. Krasteva I, Nikolov S, Kaloga M (2007). A new saponin lactone from Astragalus corniculatus. Nat Prod Res 21: 941-945.
6. Krasteva I, Nikolov S, Kaloga M, Mayer G (2006): Triterpenoid saponins from Astragalus corniculatus. Z Naturforsch 61b: 1166-1169. (Pubitemid 44621110)
7. Krasteva I, Toshkova R, Nikolov S (2004): Protective effect of Astragalus corniculatus saponins against myeloid Graffi tumor in hamsters. Phytoter Res 18: 255-257. (Pubitemid 38568757)
8. Kroemer G, Dallaporta B, Resche-Rigon M (1998): The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 60: 619-642. (Pubitemid 28157889)
9. Mitcheva M, Kondeva M, Vitcheva V, Nedialkov P, Kitanov G (2006): Effect of benzophenones from Hypericum annulatum on carbon tetrachloride-induced toxicity in freshly isolated rat hepatocytes. Redox Report 11: 3-8. (Pubitemid 44111117)
10. O'Donnell V, Burkit MJ (1994): Mitochondrial metabolism of a hydroperoxide to free radicals in human endothelial cells: An electron spin resonance spin-trapping investigation. Biochem J 304: 707-713.
11. OllingerK,BrunkUT(1995):Cellular injury induced by oxidative stress is mediated through lysosome damage. Free Radic Biol Med 19: 565-574.
12. Rate R, Bensoussan A, Fan Y (1998): Preliminary report of randomized, double-blind, placebo-controlled trail of a Chinese herbal medicine preparation CH-100 in the treatment of chronic hepatitis C. J Gastro Hep 13: 244-247. (Pubitemid 28183953)
13. Rios LJ,Waterman PG (1997): A review of the pharmacology and toxicology of Astragalus. Phytoter Res 11: 411-418. (Pubitemid 27389299)
14. Toshkova RA, Krasteva, N, Wesselinova W, Ivanov, I, Nikolov, SD (2007) Influence of purified saponin mixture from Astragalus corniculatus Bieb. on phagocytic cells in Graffi tumor bearing hamsters. J Ethnopharmacol 109: 394-399. (Pubitemid 46054369)
15. Verotta L, El-Sebakhy N (2001): Cycloartane and oleanane saponins from Astragalus sp. In: Studies in Natural Products Chemistry (Bioactive Natural Products, Part F), Elsevier Science, Karachi, pp. 179-234.
16. Weber LW, Boll M, Stampfl A (2003): Hepatotoxicity and mechanism of action of haloalkanes: Carbon tetrachloride as a toxicological model. Crit Rev Toxicol 33: 105-36. (Pubitemid 36432872)
17. Zhang Y, Gong Z, Zheng J, Liu X, Shen B (1992a): Effect of Astragalus membranaceus, injection component XGA on lipid peroxides level in mice. Acad Med Shanghai 19: 378-380.
18. Zhang YJ, Shen J, Zhu S, Huang D, Ding Y, Zhang X (1992b): Effects of Astragalus (ASI, SK) on experimental liver injury. Acta Pharm Sinica 27: 401-406.