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Volumn 11, Issue 2, 2010, Pages 311-320

A review of erlotinib an oral, selective epidermal growth factor receptor tyrosine kinase inhibitor

Author keywords

Cancer; EGFR; Erlotinib; Oncology

Indexed keywords

CIMETIDINE; CLARITHROMYCIN; CYTOCHROME P450 3A4; DILTIAZEM; DRUG METABOLITE; ERLOTINIB; GEMCITABINE; ITRACONAZOLE; KETOCONAZOLE; OSI 420; PLACEBO; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VORICONAZOLE;

EID: 76749151364     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656560903551283     Document Type: Review
Times cited : (40)

References (34)
  • 1
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med 2005;353:172-187
    • (2005) N Engl J Med , vol.353 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 2
    • 15544381413 scopus 로고    scopus 로고
    • Receptor tyrosine kinases and anticancer therapy
    • Medinger M, Drevs J. Receptor tyrosine kinases and anticancer therapy. Curr Pharm Des 2005;11:1139-1149
    • (2005) Curr Pharm des , vol.11 , pp. 1139-1149
    • Medinger, M.1    Drevs, J.2
  • 3
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J, Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000;19:6550
    • (2000) Oncogene , vol.19 , pp. 6550
    • Mendelsohn, J.1    Baselga, J.2
  • 4
    • 22144492865 scopus 로고    scopus 로고
    • Tarceva (erlotinib)exposure/effects (EE) analysis from a phase III study in advanced NSCLC: Effect of smoking on the PKof erlotinib [abstract 6165]
    • Hamilton M, Wolf JL, Zborowski D, et al. Tarceva (erlotinib)exposure/ effects (EE) analysis from a phase III study in advanced NSCLC: effect of smoking on the PKof erlotinib [abstract 6165]. Proc Am Assoc Cancer Res 2005;46:1451
    • (2005) Proc Am Assoc Cancer Res , vol.46 , pp. 1451
    • Hamilton, M.1    Wolf, J.L.2    Zborowski, D.3
  • 5
    • 33344461165 scopus 로고    scopus 로고
    • Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers
    • Ling J, Johnson KA, Miao Z, et al. Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth factor receptor tyrosine kinase, in healthy male volunteers. Drug Metab Dispos 2006;34:420-426
    • (2006) Drug Metab Dispos , vol.34 , pp. 420-426
    • Ling, J.1    Johnson, K.A.2    Miao, Z.3
  • 6
    • 33646238486 scopus 로고    scopus 로고
    • Effects of smoking on the pharmacokinetics of erlotinib
    • Hamilton M, Wolf JL, Rusk J, et al. Effects of smoking on the pharmacokinetics of erlotinib. Cancer Res 2006;1297:2166-2171
    • (2006) Cancer Res , vol.1297 , pp. 2166-2171
    • Hamilton, M.1    Wolf, J.L.2    Rusk, J.3
  • 7
    • 0035398631 scopus 로고    scopus 로고
    • Phase i and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
    • Hidalgo M, Siu LL, Nemunaitis J, et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 2001;19:3267-3279
    • (2001) J Clin Oncol , vol.19 , pp. 3267-3279
    • Hidalgo, M.1    Siu, L.L.2    Nemunaitis, J.3
  • 8
    • 34547701893 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101
    • Miller AA, Murry DJ, Owzar K, et al. Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101. J Clin Oncol 2007;25:3055-3060
    • (2007) J Clin Oncol , vol.25 , pp. 3055-3060
    • Miller, A.A.1    Murry, D.J.2    Owzar, K.3
  • 9
    • 54449085941 scopus 로고    scopus 로고
    • Pediatric phase i and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: A children's oncology group phase i consortium study
    • [Epub ahead of print]
    • Jakacki RI, Hamilton M, Gilbertson RJ, et al. Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study. J Clin Oncol 2008;26:4921-4927 [Epub ahead of print]
    • (2008) J Clin Oncol , vol.26 , pp. 4921-4927
    • Jakacki, R.I.1    Hamilton, M.2    Gilbertson, R.J.3
  • 10
    • 59449092893 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma
    • Broniscer A, Baker SJ, Stewart CF, et al. Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma. Clin Cancer Res 2009;15:701-707
    • (2009) Clin Cancer Res , vol.15 , pp. 701-707
    • Broniscer, A.1    Baker, S.J.2    Stewart, C.F.3
  • 11
    • 67650786282 scopus 로고    scopus 로고
    • Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: Case report and review of the literature
    • Christiansen SR, Broniscer A, Panetta JC, et al. Pharmacokinetics of erlotinib for the treatment of high-grade glioma in a pediatric patient with cystic fibrosis: case report and review of the literature. Pharmacotherapy 2009;29:858-866
    • (2009) Pharmacotherapy , vol.29 , pp. 858-866
    • Christiansen, S.R.1    Broniscer, A.2    Panetta, J.C.3
  • 12
    • 34249738700 scopus 로고    scopus 로고
    • Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer
    • Perez-Soler R. Rash as a surrogate marker for efficacy of epidermal growth factor receptor inhibitors in lung cancer. Clin Lung Cancer 2006;8(Suppl 1):S7-14
    • (2006) Clin Lung Cancer , vol.8 , Issue.SUPPL. 1
    • Perez-Soler, R.1
  • 13
    • 76749134172 scopus 로고    scopus 로고
    • Tarceva- [package insert]. Genentech, Inc. and OSI Pharmaceuticals, Inc.; South San Francisco, CA and Melville, NY, USA
    • Tarceva- [package insert]. Genentech, Inc. and OSI Pharmaceuticals, Inc.; South San Francisco, CA and Melville, NY, USA
  • 14
    • 11344268358 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor [review]
    • Camp ER, Summy J, Bauer TW, et al. Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor [review]. Clin Cancer Res 2005;11:397-405
    • (2005) Clin Cancer Res , vol.11 , pp. 397-405
    • Camp, E.R.1    Summy, J.2    Bauer, T.W.3
  • 15
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • [Epub ahead of print]
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73, [Epub ahead of print]
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 16
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-1043
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 17
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-132
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 18
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 2007;25:1960-1966
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 19
    • 25144488564 scopus 로고    scopus 로고
    • Approval summary for erlotinib for treatment of patients with locally advanced or metastatic nonsmall cell lung cancer after failure of at least one prior chemotherapy regimen
    • Johnson JR, Cohen M, Sridhara R, et al. Approval summary for erlotinib for treatment of patients with locally advanced or metastatic nonsmall cell lung cancer after failure of at least one prior chemotherapy regimen. Clin Cancer Res 2005;11:6414-6421
    • (2005) Clin Cancer Res , vol.11 , pp. 6414-6421
    • Johnson, J.R.1    Cohen, M.2    Sridhara, R.3
  • 20
    • 24944440830 scopus 로고    scopus 로고
    • TRIBUTE: A phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer
    • Herbst RS, Prager D, Hermann R, et al. TRIBUTE: a phase III trial of erlotinib hydrochloride (OSI-774) combined with carboplatin and paclitaxel chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 2005;23:5892-5899
    • (2005) J Clin Oncol , vol.23 , pp. 5892-5899
    • Herbst, R.S.1    Prager, D.2    Hermann, R.3
  • 21
    • 34248140107 scopus 로고    scopus 로고
    • Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: The tarceva lung cancer investigation trial
    • Gatzemeier U, Pluzanska A, Szczesna A, et al. Phase III study of erlotinib in combination with cisplatin and gemcitabine in advanced non-small-cell lung cancer: the Tarceva Lung Cancer Investigation Trial. J Clin Oncol 2007;25:1545-1552
    • (2007) J Clin Oncol , vol.25 , pp. 1545-1552
    • Gatzemeier, U.1    Pluzanska, A.2    Szczesna, A.3
  • 22
    • 70349475409 scopus 로고    scopus 로고
    • SATURN: A double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC [abstract 8001]
    • Cappuzzo F, Ciuleanu T, Stelmakh L, et al. SATURN: a double-blind, randomized, phase III study of maintenance erlotinib versus placebo following nonprogression with first-line platinum-based chemotherapy in patients with advanced NSCLC [abstract 8001]. J Clin Oncol 2009;27(Suppl):15
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 15
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3
  • 23
    • 70349477817 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC) [abstract LBA8002]
    • Miller VA, O'Connor P, Soh C, et al. A randomized, double-blind, placebo-controlled, phase IIIb trial (ATLAS) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC) [abstract LBA8002]. J Clin Oncol 2009;27(Suppl):18s
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL.
    • Miller, V.A.1    O'Connor, P.2    Soh, C.3
  • 24
    • 76749097055 scopus 로고    scopus 로고
    • Biomarker evaluation in the randomized, double-blind, placebo controlled, Phase IIIb ATLAS Trial, comparing bevacizumab (B) therapy with or without erlotinib (E), after completion of chemotherapy with B for the treatment of locally advanced, recurrent or metastatic non-small cell lung cancer (NSCLC) [abstract 8LBA]
    • Johnson B, Miller V, Amler L, et al. Biomarker evaluation in the randomized, double-blind, placebo controlled, Phase IIIb ATLAS Trial, comparing bevacizumab (B) therapy with or without erlotinib (E), after completion of chemotherapy with B for the treatment of locally advanced, recurrent or metastatic non-small cell lung cancer (NSCLC) [abstract 8LBA]. Eur J Cancer 2009;7(Suppl):5
    • (2009) Eur J Cancer , vol.7 , Issue.SUPPL. , pp. 5
    • Johnson, B.1    Miller, V.2    Amler, L.3
  • 25
    • 68649116968 scopus 로고    scopus 로고
    • Phase II trial of erlotinib in advanced pancreatic cancer [abstract 4609]
    • Tang PA, Gill S, Au HJ, et al. Phase II trial of erlotinib in advanced pancreatic cancer [abstract 4609]. J Clin Oncol 2009;27(Suppl):15
    • (2009) J Clin Oncol , vol.27 , Issue.SUPPL. , pp. 15
    • Tang, P.A.1    Gill, S.2    Au, H.J.3
  • 26
    • 76749159217 scopus 로고    scopus 로고
    • A phase II study of erlotinib in patients (pts) with advanced pancreatic cancer (APC) who are refractory to gemcitabine (G) [abstract 6603]
    • Iyer R, Khushalani N, Tan W, et al. A phase II study of erlotinib in patients (pts) with advanced pancreatic cancer (APC) who are refractory to gemcitabine (G) [abstract 6603]. Eur J Cancer 2009;7(Suppl):391
    • (2009) Eur J Cancer , vol.7 , Issue.SUPPL. , pp. 391
    • Iyer, R.1    Khushalani, N.2    Tan, W.3
  • 27
    • 74349087063 scopus 로고    scopus 로고
    • Erlotinib 150 mg daily plus chemotherapy in advanced pancreatic cancer: An interim safety analysis of a multicenter, randomized, cross-over phase III trial of the 'Arbeitsgemeinschaft Internistische Onkologie'
    • Boeck S, Vehling-Kaiserb U, Waldschmidtc D, et al. Erlotinib 150 mg daily plus chemotherapy in advanced pancreatic cancer: an interim safety analysis of a multicenter, randomized, cross-over phase III trial of the 'Arbeitsgemeinschaft Internistische Onkologie'. Anticancer Drugs 2010;21(1):94-100
    • (2010) Anticancer Drugs , vol.21 , Issue.1 , pp. 94-100
    • Boeck, S.1    Vehling-Kaiserb, U.2    Waldschmidtc, D.3
  • 28
    • 67349087409 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer
    • Dickler MN, Cobleigh MA, Miller KD, et al. Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer. Breast Cancer Res Treat 2009;115:115-121
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 115-121
    • Dickler, M.N.1    Cobleigh, M.A.2    Miller, K.D.3
  • 29
    • 33745970752 scopus 로고    scopus 로고
    • Phase II study of erlotinib in patients with advanced biliary cancer
    • Philip PA, Mahoney MR, Allmer C, et al. Phase II study of erlotinib in patients with advanced biliary cancer. J Clin Oncol 2006;24:3069-3074
    • (2006) J Clin Oncol , vol.24 , pp. 3069-3074
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 30
    • 27244447373 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer
    • Philip PA, Mahoney MR, Allmer C, et al. Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol 2005;23:6657-6663
    • (2005) J Clin Oncol , vol.23 , pp. 6657-6663
    • Philip, P.A.1    Mahoney, M.R.2    Allmer, C.3
  • 31
    • 50849108486 scopus 로고    scopus 로고
    • Results from a monocentric phase II trial of erlotinib in patients with metastatic prostate cancer
    • Gravis G, Bladou F, Salem N, et al. Results from a monocentric phase II trial of erlotinib in patients with metastatic prostate cancer. Ann Oncol 2008;19:1624-1628
    • (2008) Ann Oncol , vol.19 , pp. 1624-1628
    • Gravis, G.1    Bladou, F.2    Salem, N.3
  • 32
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-5909
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 33
    • 52049090365 scopus 로고    scopus 로고
    • Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group study BR.21
    • for the National Cancer Institute of Canada Clinical Trials Group Study BR.21
    • Zhu CQ, da Cunha Santos G, Ding K, et al.; for the National Cancer Institute of Canada Clinical Trials Group Study BR.21. Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. J Clin Oncol 2008;26:4268-4275
    • (2008) J Clin Oncol , vol.26 , pp. 4268-4275
    • Zhu, C.Q.1    Da Cunha Santos, G.2    Ding, K.3
  • 34
    • 34247149803 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
    • Lee J, Jang K, Ki S, et al. Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma. Cancer 2007;109(8):1561-1569
    • (2007) Cancer , vol.109 , Issue.8 , pp. 1561-1569
    • Lee, J.1    Jang, K.2    Ki, S.3


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