Cost-effectiveness Analysis of a Two-stage Screening Intervention for Hepatocellular Carcinoma in Taiwan

Journal of the Formosan Medical Association

Volumn 109, Issue 1, 2010, Pages 39-55

  Shih, Sophy Ting Fang ^a   Crowley, Steve ^b   Sheu, Jin Chuan ^c  

^a DEAKIN UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

cost effectiveness; hepatocellular carcinoma; mass screening; modeling

Indexed keywords

ARTICLE; CANCER MORTALITY; CANCER SCREENING; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; ECONOMIC EVALUATION; HEALTH CARE COST; HIGH RISK POPULATION; HUMAN; LIVER CELL CARCINOMA; MASS SCREENING; PATIENT MONITORING; QUALITY OF LIFE; SIMULATION; TAIWAN;

CARCINOMA, HEPATOCELLULAR; COST-BENEFIT ANALYSIS; DECISION SUPPORT TECHNIQUES; HEALTH CARE COSTS; HUMANS; LIVER NEOPLASMS; MARKOV CHAINS; MASS SCREENING; MODELS, ECONOMIC; OUTCOME AND PROCESS ASSESSMENT (HEALTH CARE); PRIMARY HEALTH CARE; TAIWAN;

EID: 76749140331     PISSN: None     EISSN: 09296646     Source Type: Journal    
DOI: 10.1016/S0929-6646(10)60020-4     Document Type: Article

References (56)

1. Department of Health. Executive Yuan, R.O.C. Cause of Death Statistics (2007)
2. Beasley R.P., Lin C.C., Hwang L.Y., et al. Hepatocellular carcinoma and hepatitis B virus: a prospective study of 22707 men in Taiwan. Lancet 2 (1981) 1129-1133
3. Heyward W.L., Lanier A.P., Bender T.R., et al. Primary hepatocellular carcinoma in Alaskan natives, 1969-1979. Int J Cancer 28 (1981) 47-50
4. Tsukuma H., Hiyama T., Tanaka S., et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N Engl J Med 328 (1993) 1797-1801
5. Tang Z.Y., and Yang B.H. Secondary prevention of hepatocellular carcinoma. J Gastroenterol Hepatol 10 (1995) 683-690
6. Kew M.C., Yu M.C., Kedda M.A., et al. The relative roles of hepatitis B and C viruses in the etiology of hepatocellular carcinoma in southern African blacks. Gastroenterology 112 (1997) 184-187
7. Chen H.L., Chang M.H., Ni Y.H., et al. Seroepidemiology of hepatitis B virus infection in children: ten years of mass vaccination in Taiwan. JAMA 276 (1996) 906-908
8. Tang Z.Y., Yang B.H., Tang C.L., et al. Evaluation of population screening for hepatocellular carcinoma. Chin Med J 93 (1980) 795-799
9. Hsu H.C., Sheu J.C., Lin Y.H., et al. Prognostic histologic features of resected small hepatocellular carcinoma (HCC) in Taiwan: a comparison with resected large HCC. Cancer 56 (1985) 672-680
10. Zoli M., Magalotti D., Bianchi G., et al. Efficacy of a surveil-lance program for early detection of hepatocellular carcinoma. Cancer 78 (1996) 977-985
11. McMahon B.J., Bulkow L., Harpster A., et al. Screening for hepatocellular carcinoma in Alaska natives infected with chronic hepatitis B: a 16-year population-based study. Hepatology 32 (2000) 842-846
12. Chen D.S., and Sung J.L. Serum alphafetoprotein in hepatocellular carcinoma. Cancer 40 (1977) 779-783
13. Sheu J.C., Chen D.S., Sung J.L., et al. Hepatocellular carcinoma: US evolution in the early stage. Radiology 155 (1985) 463-467
14. Heyward W.L., Lanier A.P., McMahon B.J., et al. Early detection of primary hepatocellular carcinoma: screening for primary hepatocellular carcinoma among persons infected with hepatitis B virus. JAMA 254 (1985) 3052-3054
15. Oka H., Tamori A., Kuroki T., et al. Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma. Hepatology 19 (1994) 61-66
16. Mima S., Sekiya C., Kanagawa H., et al. Mass screening for hepatocellular carcinoma: experience in Hokkaido, Japan. J Gastroenterol Hepatol 9 (1994) 361-365
17. Yang B.H., Zhang B.H., Xu Y.C., et al. Prospective study of early detection for primary liver cancer. J Cancer Res Clin Oncol 123 (1997) 357-360
18. Chen C.J., Lu S.N., You S.L., et al. Community-based hepatocellular carcinoma screening in seven townships in Taiwan. J Formos Med Assoc 94 Suppl 2 (1995) S94-102
19. Arguedas M.R., Chen V.K., Eloubeidi M.A., et al. Screening for hepatocellular carcinoma in patients with hepaitis C cirrhosis: a cost-utility analysis. Am J Gastroenterol 98 (2003) 679-690
20. Bolondi L., Sofia S., Siringo S., et al. Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis. Gut 48 (2001) 251-259
21. Lin O.S., Keeffe E.B., Sanders G.D., et al. Cost-effectiveness of screening for hepatocellular carcinoma in patients with cirrhosis due to chronic hepatitis C. Aliment Pharmacol Ther 19 (2004) 1159-1172
22. Sarasin F.P., Giostra E., and Hadengue A. Cost-effectiveness of screening for detection of small hepatocellular carcinoma in western patients with Child-Pugh class A cirrhosis. Am J Med 101 (1996) 422-434
23. Kang J.Y., Lee T.P., Yap I., et al. Analysis of cost-effectiveness of different strategies for hepatocellular carcinoma screening in hepatitis B virus carriers. J Gastroenterol Hepatol 7 (1992) 463-468
24. Patel D., Terrault N.A., Yao F.Y., et al. Cost-effectiveness of hepatocellular carcinoma surveillance in patients with hepatitis C virus-related cirrhosis. Clin Gastroenterol Hepatol 3 (2005) 75-84
25. Chen T.H.H., Chen C.J., Yen M.F., et al. Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in Taiwan. Int J Cancer 98 (2002) 257-261
26. Yang H.I., Lu S.N., Liaw Y.F., et al. Hepatitis B e antigen and the risk of hepatocellular carcinoma. N Engl J Med 347 (2002) 168-174
27. Tsai J.F., Jeng J.E., Ho M.S., et al. Effect of hepatitis C and B virus infection on risk of hepatocellular carcinoma: a prospective study. Br J Cancer 76 (1997) 968-974
28. Larcos G., Sorokopud H., Berry G., and Farrell G.C. Sonographic screening for hepatocellular carcinoma in patients with chronic hepatitis or cirrhosis: an evaluation. Am J Roentgenol 171 (1998) 433-435
29. Liaw Y.F., Tai D.I., Chu C.M., et al. The development of cirrhosis in patients with chronic type-B hepatitis: a prospective study. Hepatology 8 (1988) 493-496
30. Poynard T., Bedossa P., and Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 349 (1997) 825-832
31. Xu B., Hu D.C., Rosenberg D.M., et al. Chronic hepatitis B: a long-term retrospective cohort study of disease progression in Shanghai, China. J Gastroenterol Hepatol 18 (2003) 1345-1352
32. Hui A.Y., Chan H., Leung N., et al. Survival and prognostic indicators in patients with hepatitis B virus-related cirrhosis after onset of hepatic decompensation. J Clin Gastroenterol 34 (2002) 569-572
33. Fattovich G., Giustina G., Degos F., et al. Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients. Gastroenterology 112 (1997) 463-472
34. Lee C.S., Sung J.L., Hwang L.Y., et al. Surgical treatment of 109 patients with symptomatic and asymptomatic hepatocellular-carcinoma. Surgery 99 (1986) 481-490
35. Hanazaki K., Kajikawa S., Shimozawa N., et al. Survival and recurrence after hepatic resection of 386 consecutive patients with hepatocellular carcinoma. J Am Coll Surg 191 (2000) 381-388
36. Kamada K., Kitamoto M., Aikata H., et al. Combination of transcatheter arterial chemoembolization using cisplatinlipiodol suspension and percutaneous ethanol injection for treatment of advanced small hepatocellular carcinoma. Am J Surg 184 (2002) 284-290
37. Poon R.T.P., Fan S.T., Lo C.M., et al. Long-term prognosis after resection of hepatocellular carcinoma associated with hepatitis B-related cirrhosis. J Clin Oncol 18 (2000) 1094-1101
38. Sherman M., Peltekian K.M., and Lee C. Screening for hepato-cellular carcinoma in chronic carriers of hepatitis B virus: incidence and prevalence of hepatocellular carcinoma in a North American urban population. Hepatology 22 (1995) 432-438
39. Pateron D., Ganne N., Trinchet J.C., et al. Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis. J Hepatol 20 (1994) 65-71
40. Izzo F., Cremona F., Ruffolo F., et al. Outcome of 67 patients with hepatocellular cancer detected during screening of 1125 patients with chronic hepatitis. Ann Surg 227 (1998) 513-518
41. Chen C.H., Huang G.T., Lee H.S., et al. Clinical impact of screening first-degree relatives of patients with hepatocellular carcinoma. J Clin Gastroenterol 27 (1998) 236-239
42. Mathers C., Vos T., and Stevenson S. The burden of disease and injury in Australia (1999), Australian Institute of Health and Welfare, Canberra
43. Chong C., Gulamhussein A., Heathcote E.J., et al. Health-state utilities and quality of life in hepatitis C patients. Am J Gastroenterol 98 (2003) 630-638
44. Cordoba J., Flavia M., Jacas C., et al. Quality of life and cognitive function in hepatitis C at different stages of liver disease. J Hepatol 39 (2003) 231-238
45. Thein H.H., Krahn M., Kaldor J.M., et al. Estimation of utilities for chronic hepatitis C from SF-36 scores. Am J Gastroenterol 100 (2005) 643-651
46. Wun Y., and Dickinson J. Alpha-fetoprotein and/or liver ultra-sonography for liver cancer screening in patients with chronic hepatitis B. The Cochrane Library (2003) 10.1002/14651858 CD002799.
47. Pwu R. Cost-effectiveness analysis of community hepato-cellular carcinoma screening using computer simulation models (1993), Department of Public Health, National Taiwan University 109
48. Lai M.S., Yen M.F., Kuo H.S., et al. Efficacy of breast-cancer screening for female relatives of breast-cancer-index cases: Taiwan multicentre cancer screening (TAMCAS). Int J Cancer 78 (1998) 21-26
49. Chen T.H.H., Yen M.F., and Tung T.H. A computer simulation model for cost-effectiveness analysis of mass screening for Type 2 diabetes mellitus. Diabetes Res Clin Pract 54 (2001) S37-S42
50. Wang C.S., Wang S.T., and Chou P. Efficacy and cost-effectiveness of influenza vaccination of the elderly in a densely populated and unvaccinated community. Vaccine 20 (2002) 2494-2499
51. Thompson Coon J., Rogers G., Hewson P., et al. Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis. Health Technol Assess 11 (2007) 1-206
52. Lai C.L., Lau J., Wu P.C., et al. Subclinical hepatocellular-carcinoma in Hong-Kong Chinese. Oncology 49 (1992) 347-353
53. Lee C.S., Sheu J.C., Wang M., et al. Long-term outcome after surgery for asymptomatic small hepatocellular carcinoma. Br J Surg 83 (1996) 330-333
54. Yuen M.F., Cheng C.C., Lauder I.J., et al. Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience. Hepatology 31 (2000) 330-335
55. Yuen M.F., and Lai C.L. Screening for hepatocellular carcinoma: survival benefit and cost-effectiveness. Ann Oncol 14 (2003) 1463-1467
56. Trevisani F., D'Intino P.E., Morselli-Labate A.M., et al. Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status. J Hepatol 34 (2001) 570-575