Evaluation of the acute oral toxicity class of tricentric chromium(III) propionate complex in rat

Food and Chemical Toxicology

Volumn 48, Issue 3, 2010, Pages 859-864

  Staniek, Halina ^a   Krejpcio, Zbigniew ^a   Iwanik, Katarzyna ^b  

^a POZNA UNIVERSITY OF LIFE SCIENCES   (Poland)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Acute oral toxicity; Chromium(III) propionate complex; Rat

Indexed keywords

ALANINE AMINOTRANSFERASE; CHROMIUM PROPIONATE; PROPIONIC ACID; UNCLASSIFIED DRUG; WATER;

ACUTE TOXICITY; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMICAL COMPOSITION; BLOOD EXAMINATION; BODY MASS; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; EVALUATION; FEEDING; FEMALE; HISTOPATHOLOGY; LD 50; LIVER STRUCTURE; LIVER WEIGHT; MALE; NONHUMAN; RAT; TOXICITY TESTING; WISTAR RAT;

ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; DRUG-INDUCED LIVER INJURY; ENZYMES; EPISTAXIS; FEMALE; HEMOGLOBINS; KIDNEY; LETHAL DOSE 50; LIPIDS; LIVER; MALE; ORGAN SIZE; PROPIONIC ACIDS; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ULTRAVIOLET;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 76749139448     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2009.12.022     Document Type: Article

References (46)

1. Anderson R.A. Chromium and insulin resistance. Nutrition Research Reviews 16 20 (2003) 267-275
2. ATSDR, 2008. Draft Toxicological Profile for Chromium. US Department of Health and Human Services Public Health Service. Agency for Toxic Substances and Disease Registry. Available from: ().
3. Bailey M.M., Boohaker J.G., Sawyer R.D., Behling J.E., Rasco J.F., Jernigan J.J., Hood R.D., and Vincent J.B. Exposure of pregnant mice to chromium picolinate results in skeletal defects in their offspring. Birth Defects Research Part B. Developmental and Reproductive Toxicology 77 3 (2006) 244-249
4. +, in mice. Birth Defects Research Part B. Developmental and Reproductive Toxicology 83 1 (2008) 27-31
5. Bailey M.M., Boohaker J.G., Jernigan P.L., Townsend M.B., Sturdivant J., Rasco J.F., Vincent J.B., and Hood R.D. Effects of pre- and postnatal exposure to chromium picolinate or picolinic acid on neurological development in CD-1 mice. Biological Trace Element Research 124 1 (2008) 70-82
6. CELL-DYN 1700 System, 1995. Operations Manual. Abbott Laboratories, USA.
7. Cerulli J., Grabe D.W., Gauthier I., Malone M., and McGoldrick M.D. Chromium picolinate toxicity. Annals of Pharmacotherapy 32 (1998) 428-431
8. Clodfelder B.J., and Vincent J.B. The time-dependent transport of chromium in adult rats from the bloodstream to the urine. Journal of Biological Inorganic Chemistry 10 4 (2005) 383-393
9. Clodfelder B.J., Emamaullee J., Hepburn D.D.D., Chakov N.E., Nettles H.S., and Vincent J.B. The trail of chromium(III) in vivo from the blood to the urine: the roles of transferrin and chromodulin. Journal of Biological Inorganic Chemistry 6 5-6 (2001) 608-617
10. Clodfelder B.J., Chang C., and Vincent J.B. Absorption of the biomimetic chromium cation triaqua-μ3-oxo-μ-hexapropionatotrichromium(III) in rats. Biological Trace Element Research 98 2 (2004) 159-169
11. + increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic rats. Journal of Biological Inorganic Chemistry 10 2 (2005) 119-130
12. Earnshaw A., Figgis B.N., and Lewis J. Chemistry of polynuclear compounds. Part VI. Magnetic properties of trimeric chromium and iron carboxylates. Journal of Chemistry Society A: Inorganic Physical Theoretical (1966) 1656-1663
13. European Union, Council Directive 92/32/EEC of 30 April 1992 amending for the Seventh Time Directive 67/548/EEC on the Approximation of the Laws, Regulations and Administrative Provisions Relating to the Classification, Packaging and Labelling of Dangerous Substances. Available from: http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CELEX:31992L0032:EN:HTM.
14. Galuszka G., Cieslak-Golonka M., Szelag A., Starosta J., and Wojciechowska A. Synthetic models for the glucose tolerance factor: the spectroscopic characterization and toxicity studies of monomeric and dimeric Cr(III) species. Polyhedron 17 (1998) 3785-3794
15. Harton A., Terrell K., Huffman J.C., MacDonald C., Beatty A., Li S., O'Connor C.J., and Vincent J.B. Synthesis and characterization of novel oxo-bridged dinuclear and hydroxo-bridged trinuclear chromium(III) assemblies. Inorganic Chemistry 36 21 (1997) 4875-4882
16. Hininger I., Benaraba R., Osman M., Faure H., Marie Roussel A., and Anderson R.A. Safety of trivalent chromium complexes: no evidence for DNA damage in human HaCaT keratinocytes. Free Radicals in Biological Medicine 42 12 (2007) 1759-1765
17. Kuryl T., Krejpcio Z., Wójciak R.W., Lipko M., Debski B., and Staniek H. Chromium(III) propionate and dietary fructans supplementation stimulate erythrocyte glucose uptake and beta-oxidation in lymphocytes of rats. Biological Trace Element Research 114 1-3 (2006) 237-248
18. Maciejewska G., and Cieslak-Golonka M. Homo- and hetero-nuclear chromium(III) complexes with natural ligands. Part 2. Oxo- and hydroxo-bridged chromium(III)/vanadium(V) species. Transition Metal Chemistry 27 (2002) 587-592
19. Maciejewska G., Cieslak-Golonka M., and Staszak Z. Homo- and hetero-nuclear chromium(III) complexes with natural ligands. Part 3. Chromium(III)/vanadium(IV) species isolated from the redox systems. Transition Metal Chemistry 28 (2003) 96-102
20. Martin W.R., and Fuller R.E. Suspected chromium picolinate-induced rhabdomyolysis. Pharmacotherapy 18 4 (1998) 860-862
21. Miki Y. A homogenous assay for the selective measurement of LDL-cholesterol in serum. Enzymatic selective protection method. Clinical Laboratory 45 (1999) 398-401
22. Newmann D.J., and Price C.P. Renal function and nitrogen metabolites. In: Burtis C.A., and Ashwood E.R. (Eds). Tietz Textbook of Clinical Chemistry (1999), WB Saunders Company, Philadelphia 1239-1242
23. Organization for Economic Cooperation and Development (OECD), 2001. The OECD 423 Guideline for Testing of Chemicals Acute Oral Toxicity - Acute Toxic Class Method, Paris, France. Available from: ().
24. Riesen W.F. Lipid metabolism. In: Thomas L. (Ed). Clinical Laboratory Diagnostics. Use and Assessment of Clinical Laboratory Results (1998), TH-Books Verlagssesellschaft, FrankfurtMain 167-169
25. Sacks D.B., Bruns D.E., Goldstein D.E., Maclaren N.K., McDonald J.M., and Parrott M. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clinical Chemistry 48 (2002) 436-472
26. 50 test. Regulatory Toxicology and Pharmacology 42 1 (2005) 15-23
27. Schumann G., and Klauke R. New IFCC reference procedures for the determination of catalytic activity concentrations of five enzymes in serum: preliminary upper reference limits obtained in hospitalized subjects. Clinica Chimica Acta 327 (2003) 69-79
28. Shara M., Yasmin T., Kincaid A.E., Limpach A.L., Bartz J., Brenneman K.A., Chatterjee A., Bagchi M., Stohs S.J., and Bagchi D. Safety and toxicological evaluation of a novel niacin-bound chromium(III) complex. Journal of Inorganic Biochemistry 99 11 (2005) 2161-2183
29. Shara M., Kincaid A.E., Limpach A.L., Sandstrom R., Barrett L., Norton N., Bramble J.D., Yasmin T., Tran J., Chatterjee A., Bagchi M., and Bagchi D. Long-term safety evaluation of a novel oxygen-coordinated niacin-bound chromium(III) complex. Journal of Inorganic Biochemistry 101 7 (2007) 1059-1069
30. Shephard M.D., and Whiting M.J. Falsely low estimation of triglycerides in lipemic plasma by the enzymatic triglyceride method with modified Trinder's chromogen. Clinical Chemistry 36 (1990) 325-329
31. Speetjens J., Collins R., Vincent J.B., and Woski S. The nutritional supplement chromium(III) tris(picolinate) cleaves DNA. Chemical Research in Toxicology 12 (1999) 483-487
32. 3]+ do not cleave DNA under physiologically-relevant conditions. Polyhedron 18 (1999) 2617-2624
33. Staniek, H., Krejpcio, Z., 2007. Effect of dietary Cr(III) supplementation on iron indices in rat. Interaction of Xenobiotics, Polish Society of Toxicology, Poznan Branch, pp. 40-42 (in Polish).
34. Staniek H., and Krejpcio Z. The effects of tricentric chromium(III) propionate complex supplementation on pregnancy outcome and maternal and foetal mineral status in rat. Food and Chemical Toxicology 47 (2009) 2673-2678
35. Staniek H., Krejpcio Z., Szymusiak H., and Zieliński R. The effect of high-doses of chromium(III) and quercetin on selected blond biochemical indices in rat. Journal Human Nutrition and Metabolism 34 3/4 (2007) 1069-1073 (in Polish, abstract in English)
36. Staniek H., Kostrzewska-Poczekaj M., Arndt M., Szyfter K., and Krejpcio Z. Genotoxicity assessment of chromium(III) propionate complex in the rat model using the Comet assay. Food and Chemical Toxicology 48 (2010) 89-92
37. Sun Y., Ramirez J., Woski S.A., and Vincent J.B. The binding of trivalent chromium to low-molecular-weight chromium-binding substance (LMWCr) and the transfer of chromium from transferrin and chromium picolinate to LMWCr. Journal of Biological Inorganic Chemistry 5 1 (2000) 129-136
38. Thomas L. Total protein. In: Thomas L. (Ed). Clinical Laboratory Diagnostics. Use and Assessment of Clinical Laboratory Results (1998), TH-Books Verlagsgesllschaft, FrankfurtMain 644-647
39. United Nations, 2007. Globally Harmonized System of Classification and Labelling of Chemicals (GHS), ST/SGAC.10/30/Rev.2.Chapter 3.1. Available from: .
40. Vincent J.B. The biochemistry of chromium. Journal of Nutrition 130 (2000) 715-718
41. Vincent J.B. Elucidating a biological role for chromium at a molecular level. Accounts of Chemical Research 33 7 (2000) 503-510
42. Vincent J.B. The bioinorganic chemistry of chromium(III). Polyhedron 20 (2001) 1-26
43. Vincent J.B., and Bennett R. Potential and purported roles of chromium in insulin signaling: the search for the Holy Grail. In: Vincent J.B. (Ed). The Nutritional Biochemistry of Chromium(III) (2007), Elsevier 139-160
44. Wani S., Weskamp C., Marple J., and Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Annales of Pharmacotherapy 40 3 (2006) 563-566
45. Wasser W.G., and Feldman N.S. Chronic renal failure after ingestion of over-the-counter chromium picolinate. Annals of Internal Medicine 126 (1997) 410
46. Wieloch A., Wieczorek D., Staniek H., Szymusiak H., Krejpcio Z., and Zieliński R. Tricentric complexes of chromium(III) with glycine and serine ligands. Current Trends in Commodity Science vol. II (2007) 1080-1086