Evaluating bistability of Bax activation switch

FEBS Letters

Volumn 584, Issue 5, 2010, Pages 954-960

  Sun, Tingzhe ^a   Lin, Xuzhu ^a   Wei, Yinna ^a   Xu, Yichen ^a   Shen, Pingping ^a  

^a NANJING UNIVERSITY   (China)

Author keywords

Bax activation switch; Bistability; Mutual information index; Parameter uncertainty; Robustness; Switch transition

Indexed keywords

PROTEIN BAX; PROTEIN BCL 2; PUMA PROTEIN;

APOPTOSIS; ARTICLE; CELL POPULATION; CONTROLLED STUDY; GENE ACTIVATION; GENE REGULATORY NETWORK; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STABILITY; PROTEIN STRUCTURE; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SIMULATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 76749131517     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.01.034     Document Type: Article

References (32)

1. Youle R.J., and Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9 (2008) 47-59
2. Chipuk J.E., Bouchier-Hayes L., and Green D.R. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ. 13 (2006) 1396-1402
3. Galonek H.L., and Hardwick J.M. Upgrading the BCL-2 network. Nat. Cell Biol. 8 (2006) 1317-1319
4. Basañez G., and Hardwick J.M. Unraveling the Bcl-2 apoptosis code with a simple model system. PLoS Biol. 6 (2008) e154
5. Brunelle J.K., and Letai A. Control of mitochondrial apoptosis by the Bcl-2 family. J. Cell Sci. 122 (2009) 437-441
6. Billen L.P., Kokoski C.L., Lovell J.F., Leber B., and Andrews D.W. Bcl-XL inhibits membrane permeabilization by competing with Bax. PLoS Biol. 6 (2008) e147
7. Adams J.M., and Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26 (2007) 1324-1337
8. Chen C., Cui J., Lu H., Wang R., Zhang S., and Shen P. Modeling of the role of a Bax-activation switch in the mitochondrial apoptosis decision. Biophys. J. 92 (2007) 4304-4315
9. Cui J., Chen C., Lu H., Sun T., and Shen P. Two independent positive feedbacks and bistability in the bcl-2 apoptotic switch. PLoS One 3 (2008) e1469
10. Shimazu T., Degenhardt K., Nur-E-Kamal A., Zhang J., Yoshida T., Zhang Y., Mathew R., White E., and Inouye M. NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition. Gene Dev. 21 (2007) 929-941
11. Ozbudak E.M., Thattai M., Lim H.N., Shraiman B.I., and Oudenaarden A. Multistability in the lactose utilization network of Escherichia coli. Nature 427 (2004) 737-740
12. Albeck J.G., Burke J.M., Spencer S.L., Lauffenburger D.A., and Sorger P.K. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 6 (2008) e147
13. Kim H., Rafiuddin-Shah M., Tu H., Jeffers J.R., Zambetti G.P., Hsieh J.J.D., and Cheng E.H.Y. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat. Cell Biol. 8 (2006) 1348-1358
14. Wang P., Yu J., and Zhang L. The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc. Natl. Acad. Sci. USA 104 (2007) 4054-4059
15. Bannerji R., Kitada S., Flinn I.W., Pearson M., Young D., Reed J.C., and Byrd J.C. Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance. J. Clin. Oncol. 21 (2003) 1466-1471
16. Wilkinson D.J. Stochastic modeling for quantitative description of heterogeneous biological systems. Nat. Rev. Genet. 10 (2009) 122-133
17. Chen C., Cui J., Zhang W., and Shen P. Robustness analysis identifies the plausible model of the Bcl-2 apoptotic switch. FEBS Lett. 581 (2007) 5143-5150
18. Grills C., Crawford N., Chacko A., Johnston P.G., O'Rourke F., and Fennell D.A. Dynamical systems analysis of mitochondrial bak activation kinetics predicts resistance to BH3 domains. PLoS One 3 (2008) e3038
19. Bagowski C.P., and Ferrell Jr. J.E. Bistability in the JNK cascade. Curr. Biol. 11 (2001) 1176-1182
20. Karlin S., and McGregor J. A characterization of birth and death processes. Proc. Natl. Acad. Sci. USA 45 (1959) 375-379
21. Brandman O., Ferrell Jr. J.E., Li R., and Meyer T. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science 310 (2005) 496-498
22. Janes K.A., Albeck J.G., Gaudet S., Sorger P.K., Lauffenburger D.A., and Yaffe M.B. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 310 (2005) 1646-1653
23. Zhivotovsky B., and Kroemer G. Apoptosis and genomic instability. Nat. Rev. Mol. Cell Biol. 5 (2004) 752-762
24. Düssmann H., Rehm M., Concannon C.G., Anguissola S., Würstle M., Kacmar S., Völler P., Huber H.J., and Prehn J.H.M. Single-cell quantification of Bax activation and mathematical modeling suggest pore formation on minimal mitochondrial Bax accumulation. Cell Death Differ. 123 (2009) 1-13
25. Chen L., Willis S.N., Wei A., Smith B.J., Fletcher J.I., Hinds M.G., Colman P.M., Day C.L., Adams J.M., and Huang D.C.S. Differential targeting of prosurvival BCL-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol. Cell 17 (2005) 393-403
26. Igney F.H., and Krammer P.H. Death and anti-death tumour resistance to apoptosis. Nat. Rev. Cancer 2 (2002) 277-288
27. Li P.F., Dietz R., and Harsdorf R. P53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytoplasmic c-independent apoptosis blocked by Bcl-2. EMBO J. 18 (1999) 6027-6036
28. Yin C.Y., Knudson M., Korsmeyer S.J., and Dyke T.V. Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385 (1997) 637-640
29. Lebedeva I., Rando R., Wang J., Cossum P., and Stein C.A. Bcl-xL in prostate cancer cells: effects of overexpression and down-regulation on chemosensitivity. Cancer Res. 60 (2000) 6052-6060
30. Domen J., Gandy K.L., and Weissman I.L. Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood 91 (1998) 2272-2282
31. Eissing T., Conzelmann H., Gilles E.D., Allgower F., Bullinger E., and Scheurich P. Bistability analyses of a caspase activation model for receptor induced apoptosis. J. Biol. Chem. 297 (2004) 36892-36897
32. Bagci E.Z., Vodovotz Y., Billiar T.R., Ermentrout G.B., and Bahar I. Bistability in apoptosis: roles of bax, bcl-2, and mitochondrial permeability transition pores. Biophys. J. 90 (2006) 1546-1559