Metabolic support of the obese intensive care unit patient: A current perspective

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 13, Issue 2, 2010, Pages 184-191

  Port, Ava M ^a   Apovian, Caroline ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Critical illness; Hypocaloric feeding; Nutrition support; Obesity

Indexed keywords

CARBOHYDRATE METABOLISM; COMORBIDITY; CRITICALLY ILL PATIENT; ENTERIC FEEDING; FATTY ACID OXIDATION; HUMAN; HYPERGLYCEMIA; INTENSIVE CARE UNIT; LOW CALORY DIET; NUTRITIONAL SUPPORT; OBESITY; PROTEIN DEGRADATION; PROTEIN DIET; REVIEW;

BODY COMPOSITION; CALORIC RESTRICTION; CRITICAL ILLNESS; DIETARY PROTEINS; HUMANS; HYPERGLYCEMIA; INTENSIVE CARE; INTENSIVE CARE UNITS; NUTRITIONAL REQUIREMENTS; NUTRITIONAL SUPPORT; OBESITY;

EID: 76749125874     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328335f1e6     Document Type: Review

References (66)

1. Yach D, Suckler D, Brownel K. Epidemiologic and economic consequences of the global epidemics of obesity and diabetes. Nat Med 2006; 12:62-66.
2. Runge CF. Economic consequences of the obese. Diabetes 2007; 56:2668-2672.
3. Must A, Spadano J, Coakley EH, et al. The disease burden associated with overweight and obesity. JAMA 1999; 282:1523-1529.
4. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 2003; 348:1625-1638.
5. Friedenberg FK, Xanthopoulos M, Foster GD, etal. The association between gastroesophageal reflux disease and obesity. Am J Gastroenterol 2008; 103:2111.
6. Field AE, Coakley EH, Must A, et al. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 2001; 161:1581-1586.
7. Fogarty AW, Glancy C, Jones S, et al. A prospective study of weight change and systemic inflammation over 9 y. Am J Clin Nutr 2008; 87:30-35.
8. Ogden CL, Carroll MD, Curtin LR, et al. Prevalence of overweight and obesity in the United States, 1999-2004. JAMA 2006; 295:1549-1555.
9. United States Census Bureau. U.S. and world population clocks. Updated in real time. http://www.census.gov. [Accessed 3 September 2009].
10. Ogden CL, Carroll MD, McDowell MA, Flegal KM. Obesity among adults in the United States: no statistically significant changes since 2003-2004. NCHS Health Brief. November 2007; No. 1.
11. Wang Y, Beydoun MA. The obesity epidemic in the United States-gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev 2007; 29:6-28.
12. National Heart, Lung, and Blood Institute Obesity Education Initiative Expert Panel. (2000). Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. NIH publications. http://www.nhlbi.nih.gov/guidelines/obesity/prctgd-c.pdf.
13. Yaegashi M, Zuriqat M, Noack S, et al. Outcome of morbid obesity in the intensive care unit. J Intensive Care Med 2005; 20:147-154.
14. Bercault N, BoulainT, Kuteifan K, et al. Obesity-related excess mortality rate in an adult intensive care unit: a risk-adjusted matched cohort study. Crit Care Med 2004; 32:998-1003.
15. Neville AL, Brown CV, Weng J, et al. Obesity is an independent risk factor of mortality in severely injured blunt trauma patients. Arch Surg 2004; 139:983-987.
16. Dossett LA, Dageforde LA, Swenson BR, et al. Obesity and site-specificnosocomial infection risk in the intensive care unit. Surg Infect 2009; 10:137-143.
17. Smith RL, Chong TW, Hedrick TL, et al. Does body mass index affect infection-related outcomes in the intensive care unit? Surg Infect 2007; 8:581-588.
18. Oliveros H, Villamor E. Obesity and mortality in critically ill adults: a systematic review and meta-analysis. Obesity 2008; 16:515-521.
19. Akkinusi ME, Pineda LA, El Sohl AA. Effect of obesity on intensive caremorbidity and mortality: a meta-analysis. Crit Care Med 2008; 36:151-158.
20. Frat JP, Gissot V, Ragot S, et al. Impact of obesity in mechanically ventilated patients: a prospective study. Intensive Care Med 2008; 34:1991-1998.
21. Dossett LA, Heffernan D, Lightfoot M, et al. Obesity and pulmonary complications in critically injured adults. Chest 2008; 134:974-980.
22. Mullen JT, Moorman DW, Davenport DL. The obesity paradox: body mass index and outcomes in patients undergoing nonbariatric general surgery. Ann Surg 2009; 250:166-172.
23. Mizock BA. Alterations in fuel metabolism in critical illness: hyperglycaemia. Best Pract Res Clin Endocrinol Metab 2001; 15:533-551.
24. Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycemia. Lancet 2009; 373:1798-1807.
25. Honiden S, McArdle JR. Obesity in the intensive care unit. Clin Chest Med 2009; 30:581-599.
26. Jeevanandam M, Young DH, Schiller WR. Obesity and the metabolic response to severe multiple trauma in man. J Clin Invest 1991; 87:262-269.
27. Leonidou L, Michalaki M, Gogos CA, et al. Stress induced hyperglycemia in patients with severe sepsis: a compromising factor for survival. Am J Med Sci 2008; 336:467-471.
28. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive medical therapy in the medical ICU. NEJM 2006; 354:449-461.
29. Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists (AACE) and American Diabetes Association (ADA) consensus statement on inpatient glycemic control. Endocrine Practice 2009; 15:353-369.
30. Abdul-Ghani MA, Muller FL, DeFronzo RA, et al. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. Am J Physiol Endocrinol Metab 2008; 295:E678-E685.
31. Schiffelers SL, Saris WH, van Baak MA. The effect of an increased free fatty acid concentration on thermogenesis and substrate oxidation in obese and lean men. Int J Obes Relat Metab Disord 2001; 25:33-38.
32. Stevens RD, Dowdy DW, Michaels RK, et al. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med 2007; 33:1876-1891.
33. Reid CL, Campbell IT, Little RA. Muscle wasting and energy balance in critical illness. Clin Nutr 2004; 23:273-280.
34. Dickerson RN, Boschert KJ, Kudsk KA. Hypocaloric enteral tube feeding in critically ill obese patients. Nutrition 2002; 18:241-246.
35. Dickerson RN. Hypocaloric feeding of obese patients in the intensive care unit. Curr Opin Nutr Metab Care 2005; 8:189-196.
36. Biolo G, Agostini F, Simunic B, et al. Positive energy balance is associated with accelerated muscle atrophy and increased erythrocyte glutathione turnover during 5 wk of bed rest. Am J Clin Nutr 2008; 88:950-958.
37. Harris JA, Benedict FG. A biometric study of basal metabolism in man. Publication 279. Washington, DC: Carnegie Institute of Washington; 1919.
38. Mifflin MD, St. Jeor ST, Hill LA, et al. A new predictive equation for resting energy expenditure in healthy individuals. Am J Clin Nutr 1990; 51:241-247.
39. Ireton-Jones C, Jones JD. Improved equations for predicting energy expenditure in patients: the Ireton-Jones equations. Nutr Clin Pract 2002; 17:29-31.
40. Ireton-Jones CS, Turner WW, Leipa GU, et al. Equations for estimation of energy expenditures in patients with burns with special reference to ventilatory status. J Burn Care Rehab 1992; 13:330-333.
41. Frankenfield DC, Coleman A, Alam S, Cooney RN. Analysis of estimation methods for resting metabolic rate in critically ill adults. J Parenter Enteral Nutr 2009; 33:27-36.
42. Stucky CCH, Moncure M, Hise M, et al. How accurate are resting energy expenditure prediction equations in obese trauma and burn patients? JPEN 2008; 32:420.
43. Cerra FB, Benitez MR, Blackburn G, et al. Applied nutrition in ICU patients: a consensus statement of the American College of Chest Physicians. Chest 1997; 111:769-778.
44. Makita K, Nunn JF, Royston B. Evaluation of metabolic measuring instruments for use in critically ill patients. Crit Care Med 1990; 18:638-644.
45. Epstein CD, Peerless JR, Martin JE, Malangoni MA. Comparison of methods of measurements of oxygen consumption in mechanically ventilated patients with multiple trauma: the Fick method versus indirect calorimetry. Crit Care Med 2000; 28:1363-1369.
46. Wells JC, Fuller NJ. Precision and accuracy in a metabolic monitor for indirect calorimetry. Eur J Clin Nutr 1998; 52:536-540.
47. Ravussin E, Burnand B, Schutz Y, Jequier E. Twenty-four hour energy expenditure and resting metabolic rate in obese, moderately obese and control subjects. Am J Clin Nutr 1982; 35:566-573.
48. Zauner A, Schneeweiss B, Kneidinger N, et al. Weight adjusted resting energy is not constant in critically ill patients. Int Care Med 2006; 32:428-434.
49. Krenitsky J. Adjusted body weight, pro: evidence to support the use of adjusted body weight in calculating calorie requirements. Nutr Clin Pract 2005; 20:468-473.
50. McClaveSA, Martindale RG, VanekVW, et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN 2009: 277-316.
51. Anderegg BA, Worrall C, Barbour E, et al. Comparison of resting energy expenditure prediction methods with measured resting energy expenditure in obese, hospitalized adults. J Parenter Enteral Nutr 2009; 33:168-175.
52. Frankenfield DC, Rowe WA, Smith JS, et al. Validation of several established equations for resting metabolic rate in obese and nonobese people. J Am Diet Assoc 2003; 103:1152-1159.
53. Alves V, da Rocha EE, Gonzalez MC, et al. Assessment of resting energy expenditure of obese patients: comparison of indirect calorimetry with formulae. Clin Nutr 2009; 28:299-304.
54. Boullata J, Williams J, Cottrell F, et al. Accurate determination of energy needs in hospitalized patients. J Am Diet Assoc 2007; 107:393-401.
55. Hoher JA, Teixeira PJ, Hertx F, Moreira JS. A comparison between ventilation modes: how does activity level affect energy expenditure estimates? J Parenter Enteral Nutr 2008; 32:176-183.
56. ADA Executive Summary Guidelines. 'Critical illness evidence based nutrition practice guidelines'. September 2006. www.adaevidencelibrary. com.
57. Artinian V, Krayem H, DiGiovine B. Effects of early enteral feeding on the outcome of critically ill mechanically ventilated medical patients. Chest 2006; 129:960-967.
58. Palghi A, Reed JL, Greenburg I, et al. Multidisciplinary treatment of obesity with a protein-sparing modified fast: results in 668 outpatients. Am J Public Health 1985; 75:1190-1194.
59. Krishnan JA, PArce PB, Martinez A. Caloric intake in medical ICU patients: consistency of care with guidelines and relationship to clinical outcomes. Nutr Clin Pract 2004; 19:645-646.
60. Choban PS, Burge JC, Scales D, Flancbaum L. Hypoenergetic nutrition support in hospitalized obese patients: a simplified method for clinical application. Am J Clin Nutr 1997; 66:546-550.
61. Villet S, Chiolero RL, Bollmann MD, et al. Negative impact of hypocaloric feeding and energy balance on clinical outcome in ICU patients. Clin Nutr 2005; 24:502-509.
62. Hahler B. Morbid obesity: a nursing care challenge. Medsurg Nurs 2002; 11:85-90.
63. Davidson JE, Kruse MW, Cox DH, Duncan R. Critical care of the morbidly obese. Crit Care Nurs 2003; 26:105-116.
64. Winkelman C, Maloney B. Obese ICU patients: resource utilization and outcomes. Clin Nurs Res 2005; 14:303.
65. Alexander JW. Wounds in the morbidly obese. Obes Surg 2005; 15:1276-1277.
66. Wheaton G, Marden P, Colleypreist B, et al. Understanding why patients die after gastrostomy tube insertion: a retrospective analysis of mortality. JPEN 2009; 33:375-379.