Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 2, 2010, Pages 684-689

  Kakimoto, Kazuki ^a   Takai, Shinji ^a   Murano, Mitsuyuki ^a   Ishida, Kumi ^a   Yoda, Yukiko ^a   Inoue, Takuya ^a   Jin, Denan ^a   Umegaki, Eiji ^a   Higuchi, Kazuhide ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 (5 FLUORO 3 METHYLBENZO[B]THIOPHEN 2 YL)SULFONAMIDO 3 METHANESULFONYLPHENYL]THIAZOLE 4 CARBOXYLIC ACID; 5 ETHOXYMETHOXY N HYDROXY 2 METHYL 4 (4 PHENOXYBENZAMIDO)PENTANAMIDE; CHYMASE INHIBITOR; GASTROINTESTINAL AGENT; GELATINASE B; INDOMETACIN; MYELOPEROXIDASE; PLACEBO; TY 51469; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG INHIBITION; INTESTINE INJURY; MALE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH INJURY; ZYMOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHYMASES; ENTERITIS; ENZYME INHIBITORS; INDOMETHACIN; INTESTINE, SMALL; MALE; MATRIX METALLOPROTEINASE 9; PEROXIDASE; PHENYL ETHERS; RATS; RATS, SPRAGUE-DAWLEY; SULFONAMIDES; THIOPHENES; TIME FACTORS;

EID: 76749123383     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.162933     Document Type: Article

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