Assessment of the validity of the frequently used lipid indices for predicting LDL peak particle diameter in a large cohort of 1955 normal and dyslipidemic subjects

Clinical Biochemistry

Volumn 43, Issue 4-5, 2010, Pages 401-406

  Décary, Simon ^a,b   Dumont, Geneviève ^a,b   Lamarche, Benoît ^b   Hogue, Jean Charles ^a,b   Tremblay, André J ^a,b   Bergeron, Jean ^a   Couture, Patrick ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

LDL phenotype; LDL size; Plasma triglycerides

Indexed keywords

APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CHILD; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT TOOL; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE MARKER; DYSLIPIDEMIA; FEMALE; HUMAN; INTERMETHOD COMPARISON; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PARTICLE SIZE; PHENOTYPE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; REPRODUCIBILITY; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY; TRIACYLGLYCEROL BLOOD LEVEL; VALIDATION PROCESS; VALIDITY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; CHOLESTEROL, LDL; COHORT STUDIES; DYSLIPIDEMIAS; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; PARTICLE SIZE; PHENOTYPE; ROC CURVE; VALIDATION STUDIES AS TOPIC; YOUNG ADULT;

EID: 76749115216     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2009.11.010     Document Type: Article

References (46)

1. Berneis K.K., and Krauss R.M. Metabolic origins and clinical significance of LDL heterogeneity. J. Lipid Res. 43 (2002) 1363-1379
2. Krauss R.M., and Burke D.J. Identification of multiple subclasses of plasma low density lipoproteins in normal humans. J. Lipid Res. 23 (1982) 97-104
3. Talmud P.J., Edwards K.L., Turner C.M., et al. Linkage of the cholesteryl ester transfer protein (CETP) gene to LDL particle size: use of a novel tetranucleotide repeat within the CETP promoter. Circulation 101 (2000) 2461-2466
4. Carr M.C., Ayyobi A.F., Murdoch S.J., Deeb S.S., and Brunzell J.D. Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 667-673
5. Lamarche B., and Paradis M.E. Endothelial lipase and the metabolic syndrome. Curr. Opin. Lipidol. 18 (2007) 298-303
6. Austin M.A. Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype. Curr. Atheroscler. Rep. 2 (2000) 200-207
7. Tribble D.L. Lipoprotein oxidation in dyslipidemia: insights into general mechanisms affecting lipoprotein oxidative behavior. Curr. Opin. Lipidol. 6 (1995) 196-208
8. La Belle M., and Krauss R.M. Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns. J. Lipid Res. 31 (1990) 1577-1588
9. McNamara J.R., Small D.M., Li Z., and Schaefer E.J. Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B. J. Lipid Res. 37 (1996) 1924-1935
10. Flood C., Gustafsson M., Pitas R.E., et al. Molecular mechanism for changes in proteoglycan binding on compositional changes of the core and the surface of low-density lipoprotein-containing human apolipoprotein B100. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 564-570
11. Rainwater D.L. Lipoprotein correlates of LDL particle size. Atherosclerosis 148 (2000) 151-158
12. Tchernof A., Lamarche B., Prud'Homme D., et al. The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care 19 (1996) 629-637
13. McNamara J.R., Campos H., Ordovas J.M., et al. Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Results from the Framingham Offspring Study. Arteriosclerosis 7 (1987) 483-490
14. Stampfer M.J., Krauss R.M., Ma J., et al. A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA 276 (1996) 882-888
15. McLaughlin T., Reaven G., Abbasi F., et al. Is there a simple way to identify insulin-resistant individuals at increased risk of cardiovascular disease?. Am. J. Cardiol. 96 (2005) 399-404
16. Hattori Y., Suzuki M., Tsushima M., et al. Development of approximate formula for LDL-chol, LDL-apo B and LDL-chol/LDL-apo B as indices of hyperapobetalipoproteinemia and small dense LDL. Atherosclerosis 138 (1998) 289-299
17. Wagner A.M., Jorba O., Rigla M., et al. LDL-cholesterol/apolipoprotein B ratio is a good predictor of LDL phenotype B in type 2 diabetes. Acta Diabetol. 39 (2002) 215-220
18. Yoshida A., Kouwaki M., Matsutani Y., Fukuchi Y., and Naito M. Usefulness of serum total cholesterol/triglyceride ratio for predicting the presence of small, dense LDL. J. Atheroscler. Thromb. 11 (2004) 215-219
19. Bhalodkar N.C., Blum S., and Enas E.A. Accuracy of the ratio of triglycerides to high-density lipoprotein cholesterol for predicting low-density lipoprotein cholesterol particle sizes, phenotype B, and particle concentrations among Asian Indians. Am. J. Cardiol. 97 (2006) 1007-1009
20. Tsimihodimos V., Gazi I., Kostara C., Tselepis A.D., and Elisaf M. Plasma lipoproteins and triacylglycerol are predictors of small, dense LDL particles. Lipids 42 (2007) 403-409
21. Hanak V., Munoz J., Teague J., Stanley Jr. A., and Bittner V. Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B. Am. J. Cardiol. 94 (2004) 219-222
22. Dobiasova M., and Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin. Biochem. 34 (2001) 583-588
23. Boizel R., Benhamou P.Y., Lardy B., et al. Ratio of triglycerides to HDL cholesterol is an indicator of LDL particle size in patients with type 2 diabetes and normal HDL cholesterol levels. Diabetes Care 23 (2000) 1679-1685
24. Maruyama C., Imamura K., and Teramoto T. Assessment of LDL particle size by triglyceride/HDL-cholesterol ratio in non-diabetic, healthy subjects without prominent hyperlipidemia. J. Atheroscler. Thromb. 10 (2003) 186-191
25. Lind L., Vessby B., and Sundstrom J. The apolipoprotein B/AI ratio and the metabolic syndrome independently predict risk for myocardial infarction in middle-aged men. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 406-410
26. Connelly P.W., MacLean D.R., Horlick L., et al. Plasma lipids and lipoproteins and the prevalence of risk for coronary heart disease in Canadian adults. Canadian Heart Health Surveys Research Group. CMAJ 146 (1992) 1977-1987
27. Connelly P.W., Poapst M., Davignon J., et al. Reference values of plasma apolipoproteins A-I and B, and association with nonlipid risk factors in the populations of two Canadian provinces: Quebec and Saskatchewan. Canadian Heart Health Surveys Research Group. Can. J. Cardiol. 15 (1999) 409-418
28. Havel R.J., Eder H., and Bragdon J. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J. Clin. Invest. 34 (1955) 1345-1353
29. Albers J.J., Warnick G.R., Wiebe D., et al. Multi-laboratory comparison of three heparin-Mn2+ precipitation procedures for estimating cholesterol in high-density lipoprotein. Clin. Chem. 24 (1978) 853-856
30. St-Pierre A.C., Ruel I.L., Cantin B., et al. Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease. Circulation 104 (2001) 2295-2299
31. Landis J.R., and Koch G.G. The measurement of observer agreement for categorical data. Biometrics 33 (1977) 159-174
32. DeLong E.R., DeLong D.M., and Clarke-Pearson D.L. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44 (1988) 837-845
33. MacLean D.R., Petrasovits A., Connelly P.W., et al. Plasma lipids and lipoprotein reference values, and the prevalence of dyslipoproteinemia in Canadian adults. Canadian Heart Health Surveys Research Group. Can. J. Cardiol. 15 (1999) 434-444
34. Sniderman A.D., Tremblay A.J., Bergeron J., Gagné C., and Couture P. Diagnosis of type III hyperlipoproteinemia from plasma total cholesterol, triglyceride and apoB. Clin. J. Lipidol. 1 (2007) 256-263
35. Singh A.T., Rainwater D.L., Haffner S.M., et al. Effect of diabetes on lipoprotein size. Arterioscler. Thromb. Vasc. Biol. 15 (1995) 1805-1811
36. Lamarche B., Lemieux I., and Després J.P. The small, dense LDL phenotype and the risk of coronary heart disease: epidemiology, patho-physiology and therapeutic aspects. Diabetes Metab. 25 (1999) 199-211
37. Lemieux I., Lamarche B., Couillard C., et al. Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Arch. Intern. Med. 161 (2001) 2685-2692
38. Ambrosch A., Muhlen I., Kopf D., et al. LDL size distribution in relation to insulin sensitivity and lipoprotein pattern in young and healthy subjects. Diabetes Care 21 (1998) 2077-2084
39. Rizzo M., Barbagallo C.M., Severino M., et al. Low-density-lipoprotein peak particle size in a Mediterranean population. Eur. J. Clin. Invest. 33 (2003) 126-133
40. St-Pierre A.C., Cantin B., Dagenais G.R., et al. The triglyceride/high-density lipoprotein cholesterol ratio, the small dense low-density lipoprotein phenotype, and ischemic heart disease risk. Metab. Syndr. Relat. Disord. 2 (2004) 57-64
41. Austin M.A., Brunzell J.D., Fitch W.L., and Krauss R.M. Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis 10 (1990) 520-530
42. Kwiterovich Jr. P.O. Clinical relevance of the biochemical, metabolic, and genetic factors that influence low-density lipoprotein heterogeneity. Am. J. Cardiol. 90 (2002) 30i-47i
43. Hogue J.C., Lamarche B., Gaudet D., et al. Relationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia. J. Lipid Res. 45 (2004) 1077-1083
44. Paradis M.E., Hogue M.O., Mauger J.F., et al. Visceral adipose tissue accumulation, secretory phospholipase A(2)-IIA and atherogenecity of LDL. Int. J. Obes. (Lond.) (2006)
45. Campos H., Genest Jr. J.J., Blijlevens E., et al. Low density lipoprotein particle size and coronary artery disease. Arterioscler. Thromb. 12 (1992) 187-195
46. Ruel I.L., Gaudet D., Perron P., et al. Characterization of LDL particle size among carriers of a defective or a null mutation in the lipoprotein lipase gene: the Quebec LIPD Study. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 1181-1186