Sterile alpha motif domain-mediated self-association plays an essential role in modulating the activity of the Drosophila ETS family transcriptional repressor yan

Molecular and Cellular Biology

Volumn 30, Issue 5, 2010, Pages 1158-1170

  Zhang, Jie ^a   Graham, Thomas G W ^b   Vivekanand, Pavithra ^c   Cote, Lauren ^a   Cetera, Maureen ^a   Rebay, Ilaria ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c FRANKLIN AND MARSHALL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN YAN; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DROSOPHILA MELANOGASTER; EMBRYO DEVELOPMENT; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; RETINA DEVELOPMENT;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; CELL LINE; DNA PRIMERS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EYE; EYE PROTEINS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GREEN FLUORESCENT PROTEINS; MAP KINASE SIGNALING SYSTEM; MUTATION, MISSENSE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTOR PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSFECTION;

DROSOPHILA MELANOGASTER;

EID: 76749109939     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01225-09     Document Type: Article

References (36)

1. Baker, D. A., B. Mille-Baker, S. M. Wainwright, D. Ish-Horowicz, and N. J. Dibb. 2001. Mae mediates MAP kinase phosphorylation of Ets transcription factors in Drosophila. Nature 411:330-334.
2. Bohlander, S. K. 2005. ETV6: a versatile player in leukemogenesis. Semin. Cancer Biol. 15:162-174.
3. Brunner, D., K. Ducker, N. Oellers, E. Hafen, H. Scholz, and C. Klambt. 1994. The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway. Nature 370:386-389.
4. Flores, G. V., H. Duan, H. Yan, R. Nagaraj, W. Fu, Y. Zou, M. Noll, and U. Banerjee. 2000. Combinatorial signaling in the specification of unique cell fates. Cell 103:75-85.
5. Gabay, L., H. Scholz, M. Golembo, A. Klaes, B. Z. Shilo, and C. Klambt. 1996. EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm. Development 122:3355-3362.
6. Golembo, M., R. Schweitzer, M. Freeman, and B. Z. Shilo. 1996. Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop. Development 122:223-230.
7. Halfon, M. S., A. Carmena, S. Gisselbrecht, C. M. Sackerson, F. Jimenez, M. K. Baylies, and A. M. Michelson. 2000. Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell 103:63-74.
8. Hsu, T., and R. A. Schulz. 2000. Sequence and functional properties of Ets genes in the model organism Drosophila. Oncogene 19:6409-6416.
9. Kim, C. A., M. Gingery, R. M. Pilpa, and J. U. Bowie. 2002. The SAM domain of polyhomeotic forms a helical polymer. Nat. Struct. Biol. 9:453-457.
10. Kim, C. A., M. L. Phillips, W. Kim, M. Gingery, H. H. Tran, M. A. Robinson, S. Faham, and J. U. Bowie. 2001. Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression. EMBO J. 20:4173-4182.
11. Kim, C. A., M. R. Sawaya, D. Cascio, W. Kim, and J. U. Bowie. 2005. Structural organization of a Sex-comb-on-midleg/polyhomeotic copolymer. J. Biol. Chem. 280:27769-27775.
12. Klämbt, C. 1993. The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells. Development 117:163-176.
13. Lai, Z. C., and G. M. Rubin. 1992. Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein. Cell 70:609-620.
14. Laudet, V., C. Hanni, D. Stehelin, and M. Duterque-Coquillaud. 1999. Molecular phylogeny of the ETS gene family. Oncogene 18:1351-1359.
15. Lippincott-Schwartz, J., E. Snapp, and A. Kenworthy. 2001. Studying protein dynamics in living cells. Nat. Rev. Mol. Cell Biol. 2:444-456.
16. Lopez, R. G., C. Carron, C. Oury, P. Gardellin, O. Bernard, and J. Ghysdael. 1999. TEL is a sequence-specific transcriptional repressor. J. Biol. Chem. 274:30132-30138.
17. Mavrothalassitis, G., and J. Ghysdael. 2000. Proteins of the ETS family with transcriptional repressor activity. Oncogene 19:6524-6532.
18. O'Neill, E. M., I. Rebay, R. Tjian, and G. M. Rubin. 1994. The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway. Cell 78:137-147.
19. Peterson, A. J., M. Kyba, D. Bornemann, K. Morgan, H. W. Brock, and J. Simon. 1997. A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions. Mol. Cell. Biol. 17:6683-6692.
20. Qiao, F., H. Song, C. A. Kim, M. R. Sawaya, J. B. Hunter, M. Gingery, I. Rebay, A. J. Courey, and J. U. Bowie. 2004. Derepression by depolymerization: structural insights into the regulation of Yan by Mae. Cell 118:163-173.
21. Rebay, I., and G. M. Rubin. 1995. Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway. Cell 81:857-866.
22. Rogge, R., P. J. Green, J. Urano, S. Horn-Saban, M. Mlodzik, B. Z. Shilo, V. Hartenstein, and U. Banerjee. 1995. The role of yan in mediating the choice between cell division and differentiation. Development 121:3947-3958.
23. Roseman, R. R., K. Morgan, D. R. Mallin, R. Roberson, T. J. Parnell, D. J. Bornemann, J. A. Simon, and P. K. Geyer. 2001. Long-range repression by multiple polycomb group (PcG) proteins targeted by fusion to a defined DNA-binding domain in Drosophila. Genetics 158:291-307.
24. Roukens, M. G., M. Alloul-Ramdhani, S. Moghadasi, M. Op den Brouw, and D. A. Baker. 2008. Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-boxmediated ubiquitination. Mol. Cell. Biol. 28:4394-4406.
25. Roukens, M. G., M. Alloul-Ramdhani, A. C. Vertegaal, Z. Anvarian, C. I. Balog, A. M. Deelder, P. J. Hensbergen, and D. A. Baker. 2008. Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function. Mol. Cell. Biol. 28:2342-2357.
26. Schneider, I. 1972. Cell lines derived from late embryonic stages of Drosophila melanogaster. J. Embryol. Exp. Morphol. 27:353-365.
27. Scholz, H., J. Deatrick, A. Klaes, and C. Klambt. 1993. Genetic dissection of pointed, a Drosophila gene encoding two ETS-related proteins. Genetics 135:455-468.
28. Song, H., M. Nie, F. Qiao, J. U. Bowie, and A. J. Courey. 2005. Antagonistic regulation of Yan nuclear export by Mae and Crm1 may increase the stringency of the Ras response. Genes Dev. 19:1767-1772.
29. Tei, H., I. Nihonmatsu, T. Yokokura, R. Ueda, Y. Sano, T. Okuda, K. Sato, K. Hirata, S. C. Fujita, and D. Yamamoto. 1992. pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor. Proc. Natl. Acad. Sci. U. S. A. 89:6856-6860.
30. Tognon, C. E., C. D. Mackereth, A. M. Somasiri, L. P. McIntosh, and P. H. Sorensen. 2004. Mutations in the SAM domain of the ETV6-NTRK3 chimeric tyrosine kinase block polymerization and transformation activity. Mol. Cell. Biol. 24:4636-4650.
31. Tootle, T. L., P. S. Lee, and I. Rebay. 2003. CRM1-mediated nuclear export and regulated activity of the receptor tyrosine kinase antagonist YAN require specific interactions with MAE. Development 130:845-857.
32. Tran, H. H., C. A. Kim, S. Faham, M. C. Siddall, and J. U. Bowie. 2002. Native interface of the SAM domain polymer of TEL. BMC Struct. Biol. 2:5.
33. Vivekanand, P., and I. Rebay. 2006. Intersection of signal transduction pathways and development. Annu. Rev. Genet. 40:139-157.
34. Vivekanand, P., T. L. Tootle, and I. Rebay. 2004. MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN. Mech. Dev. 121:1469-1479.
35. Xu, C., R. C. Kauffmann, J. Zhang, S. Kladny, and R. W. Carthew. 2000. Overlapping activators and repressors delimit transcriptional response to receptor tyrosine kinase signals in the Drosophila eye. Cell 103:87-97.
36. Zacharias, D. A., J. D. Violin, A. C. Newton, and R. Y. Tsien. 2002. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296:913-916.