Patient-tailored, imaging-guided, long-term temozolomide chemotherapy in patients with glioblastoma

Molecular Imaging

Volumn 9, Issue 1, 2010, Pages 40-46

  Galldiks, Norbert ^a,b,c,d   Kracht, Lutz W ^a,b,c,d   Burghaus, Lothar ^a,b,c,d   Ullrich, Roland T ^a,b,c,d   Backes, Heiko ^a,b,c,d   Brunn, Anna ^a,b,c,d   Heiss, Wolf Dieter ^a,b,c,d   Jacobs, Andreas H ^a,b,c,d  

^a MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c KLINIKUM FULDA   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGIC ACTIVITIES; CLINICAL COURSE; COMPLETE RESPONSE; DOSE ESCALATION; GLIOBLASTOMAS; INITIAL TREATMENT; L-METHIONINE; METABOLIC ACTIVITY; PET IMAGING; TEMOZOLOMIDE; TUMOR ACTIVITY;

CHEMOTHERAPY; MAGNETIC RESONANCE IMAGING; RESONANCE; TUMORS;

POSITRON EMISSION TOMOGRAPHY;

2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 5' DEOXY 5'FLUOROTHYMIDINE; 5'-DEOXY-5'FLUOROTHYMIDINE; ALKYLATING AGENT; CARBON; DACARBAZINE; DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORINE; METHIONINE; METHIONINE METHYL ESTER; RADIOPHARMACEUTICAL AGENT; TEMOZOLOMIDE;

ADULT; ARTICLE; BRAIN TUMOR; CASE REPORT; GLIOBLASTOMA; HUMAN; METABOLISM; MIDDLE AGED; SCINTISCANNING;

ADULT; ANTINEOPLASTIC AGENTS, ALKYLATING; BRAIN NEOPLASMS; CARBON RADIOISOTOPES; DACARBAZINE; DIDEOXYNUCLEOSIDES; FLUORINE RADIOISOTOPES; GLIOBLASTOMA; HUMANS; METHIONINE; MIDDLE AGED; RADIOPHARMACEUTICALS;

EID: 76749104844     PISSN: 15353508     EISSN: None     Source Type: Journal    
DOI: 10.2310/7290.2010.00002     Document Type: Article

References (37)

1. Stupp R, Gander M, Leyvraz S, Newlands E . Current and future developments in the use of temozolomide for the treatment of brain tumours. Lancet Oncol 2001; 2: 552-560
2. DeAngelis LM . Benefits of adjuvant chemotherapy in highgrade gliomas. Semin Oncol 2003; 30: 15-18
3. Ataman F, Poortmans P, Stupp R , et al. Quality assurance of the EORTC 26981/22981; NCIC CE3 intergroup trial on radiotherapy with or without temozolomide for newlydiagnosed glioblastoma multiforme: the individual case review. Eur J Cancer 2004; 40: 1724-1730
4. Stupp R, Mason WP, van den Bent MJ , et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352: 987-996
5. Stupp R, Dietrich PY, Ostermann Kraljevic S , et al . Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 2002; 20: 1375-1382
6. Gilbert MR, Loghin M . The treatment of malignant gliomas. Curr Treat Options Neurol 2005; 7: 293-303.
7. Berger G, Maziere M, Knipper R , et al. Automated synthesis of 11C-labelled radiopharmaceuticals: imipramine, chlorpromazine, nicotine and methionine. Int J Appl Radiat Isot 1979; 30: 393-399
8. Machulla H, Blocher A, Kuntzsch M , et al . Simplified labeling approach for synthesizing 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT). Radioanal Nucl Chem 2000; 243: 843-846
9. Wodarski C, Eisenbarth J, Weber K , et al. Synthesis of 3'-deoxy-3'-[18F]fluoro-thymidine with 2,3'-anhydro-5'-O- (4,4'-dimethoxytrityl) -thymidine. J Labelled Cpd Radiopharm 2000; 43: 1211-1218
10. Jacobs AH, Thomas A, Kracht LW , et al. 18F-Fluoro-Lthymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors. J Nucl Med 2005; 46: 1948-1958
11. Kracht LW, Friese M, Herholz K , et al . Methyl-[11C]- l-methionine uptake as measured by positron emission tomography correlates to microvessel density in patients with glioma. Eur J Nucl Med Mol Imaging 2003; 30: 868-873
12. Backes H, Ullrich R, Neumaier B , et al. Noninvasive quantification of (18)F-FLT human brain PET for the assessment of tumour proliferation in patients with high-grade glioma. Eur J Nucl Med Mol Imaging. 2009 Aug 12. [Epub ahead of print]
13. Wick W, Steinbach JP, Kuker WM , et al. One week on/one week off: a novel active regimen of temozolomide for recurrent glioblastoma. Neurology 2004; 62: 2113-2115
14. Hunter C, Smith R, Cahill DP , et al. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res 2006; 66: 3987-3991
15. Kaschten B, Stevenaert A, Sadzot B , et al . Preoperative evaluation of 54 gliomas by PET with fluorine-18-fluorodeoxyglucose and/or carbon-11-methionine. J Nucl Med 1998; 39: 778-785
16. Galldiks N, Kracht LW, Burghaus L , et al . Use of (11) C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas. Eur J Nucl Med Mol Imaging 2006; 33: 516-524
17. Nuutinen J, Sonninen P, Lehikoinen P , et al. Radiotherapy treatment planning and long-term follow-up with [(11)C] methionine PET in patients with low-grade astrocytoma. Int J Radiat Oncol Biol Phys 2000; 48: 43-52.
18. Würker M, Herholz K, Voges J , et al. Glucose consumption and methionine uptake in low-grade gliomas after iodine- 125 brachytherapy. Eur J Nucl Med 1996; 23: 583-586
19. Voges J, Herholz K, Holzer T , et al . 11C-Methionine and 18F-2-fluorodeoxyglucose positron emission tomography: a tool for diagnosis of cerebral glioma and monitoring after brachytherapy with 125I seeds. Stereotact Funct Neurosurg 1997; 69: 129-135
20. Shintani S, Tsuruoka S, Shiigai T . Serial positron emission tomography (PET) in gliomatosis cerebri treated with radiotherapy: a case report. J Neurol Sci 2000; 173: 25-31.
21. Herholz K, Holzer T, Bauer B , et al . 11C-Methionine PET for differential diagnosis of low-grade gliomas. Neurology 1998; 50: 1316-1322
22. Tovi M, Lilja A, Bergstrom M , et al . Delineation of gliomas with magnetic resonance imaging using Gd-DTPA in comparison with computed tomography and positron emission tomography. Acta Radiol 1990; 31: 417-429
23. Kracht LW, Miletic H, Busch S , et al . Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology. Clin Cancer Res 2004; 10: 7163-7170
24. Pauleit D, Floeth F, Hamacher K , et al . O-(2-[18F]Fluoroethyl)- L-tyrosine PET combined with MRI improves the diagnostic assessment of cerebral gliomas. Brain 2005; 128: 678-687
25. Reinhardt MJ, Kubota K, Yamada S , et al . Assessment of cancer recurrence in residual tumors after fractionated radiotherapy: a comparison of fluorodeoxyglucose, L-methionine and thymidine. J Nucl Med 1997; 38: 280-287
26. Sonoda Y, Kumabe T, Takahashi T , et al . Clinical usefulness of 11C-MET PET and 201T1 SPECT for differentiation of recurrent glioma from radiation necrosis. Neurol Med Chir (Tokyo) 1998; 38: 342- 7, discussion 347-348
27. Dandois V, Rommel D, Renard L , et al . Substitution of 11C-methionine PET by perfusion MRI during the follow-up of treated high-grade gliomas: preliminary results in clinical practice. J Neuroradiol. 2009 Jun 29. [Epub ahead of print]
28. Bustany P, Chatel M, Derlon JM , et al. Brain tumor protein synthesis and histological grades: a study by positron emission tomography (PET) with C11-L-methionine. J Neurooncol 1986; 3: 397-404.
29. Herholz K, Kracht LW, Heiss WD . Monitoring the effect of chemotherapy in a mixed glioma by C-11-methionine PET. J Neuroimaging 2003; 13: 269-271
30. Muzi M, Spence AM, O'Sullivan F , et al . Kinetic analysis of 3'-deoxy-3'-18F-fluorothymidine in patients with gliomas. J Nucl Med 2006; 47: 1612-1621
31. Yamamoto Y, Wong TZ, Turkington TG , et al . 3'-Deoxy-3'- [F-18]fluorothymidine positron emission tomography in patients with recurrent glioblastoma multiforme: comparison with Gd-DTPA enhanced magnetic resonance imaging. Mol Imaging Biol 2006; 8: 340-347
32. Chen W, Cloughesy T, Kamdar N , et al. Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG. J Nucl Med 2005; 46: 945-952
33. Saga T, Kawashima H, Araki N , et al. Evaluation of primary brain tumors with FLT-PET: usefulness and limitations. Clin Nucl Med 2006; 31: 774-780
34. Choi SJ, Kim JS, Kim JH , et al. [18F]3'-Deoxy-3'- fluorothymidine PET for the diagnosis and grading of brain tumors. Eur J Nucl Med Mol Imaging 2005; 32: 653-659
35. Hatakeyama T, Kawai N, Nishiyama Y , et al . 11C-Methionine (MET) and 18F-fluorothymidine (FLT) PET in patients with newly diagnosed glioma. Eur J Nucl Med Mol Imaging 2008; 35: 2009-2017
36. Kawai N, Kagawa M, Miyake K , et al . Use of 11F-fluorothymidine positron emission tomography in brain tumor. No Shinkei Geka 2009; 37: 657-664
37. Ullrich R, Backes H, Li H , et al. Glioma proliferation as assessed by 3?-fluoro-3?-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed highgrade glioma. Clin Cancer Res 2008; 14: 2049-2055