Proteomics analysis of cardiac muscle from rats with peroxisomal proliferator-activated receptor a (PPARα) stimulation

Journal of Toxicological Sciences

Volumn 35, Issue 1, 2010, Pages 131-135

  Miyazaki, Masafumi ^a,b   Nakagawa, Ippei ^b   Koga, Shigeru ^b   Kasahara, Yasushi ^b   Patricelli, Matthew P ^a  

^a ACTIVX BIOSCIENCES INC   (United States)

^b KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Clofibrate; Fenofibrate; Heart; LC MS MS based proteomics

Indexed keywords

CLOFIBRATE; FENOFIBRATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE ACTIVATION; HEART MUSCLE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEOMICS; RAT;

RATTUS;

EID: 76749095472     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.131     Document Type: Article

References (11)

1. Adam, G.C., Burbaum, J., Kozarich, J.W., Patricelli, M.P. and Cravatt, B.F. (2004): Mapping enzyme active sites in complex proteomes. J. Am. Chem. Soc, 126, 1363-1368.
2. Auboeuf, D., Rieusset, J., Fajas, L., Vallier, P., Frering, V., Riou, J.P., Staels, B., Auwerx, J., Laville, M. and Vidal, H. (1997): Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-α in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes, 46, 1319-1327.
3. Chiodi, P., Maccari, F. and Ramacci, M.T. (1992): Tissue lipid accumulation by L-aminocarnitine, an inhibitor of carnitine- palmitoyltransferase-2. Studies in intact rats and isolated mitochondria. Biochim. Biophys. Acta., 1127, 81-86.
4. Kornberg, A. and Pricer, W.E.Jr. (1953): Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids. J. Biol. Chem., 204, 329-343.
5. Léonard, J.F., Courcol, M., Mariet, C., Charbonnier, A., Boitier, E., Duchesne, M., Parker, F., Genet, B., Supatto, F., Roberts, R. and Gautier, J.C. (2006): Proteomic characterization of the effects of clofibrate on protein expression in rat liver. Proteomics, 6, 1915-1933.
6. Okerberg, E.S., Wu, J., Zhang, B., Samii, B., Blackford, K., Winn, D.T., Shreder, K.R., Burbaum, J.J. and Patricelli, M.P. (2005): High-resolution functional proteomics by active-site peptide profiling. Proc. Natl. Acad. Sci. U. S. A., 102, 4996-5001.
7. Pruimboom-Brees, I., Haghpassand, M., Royer, L., Brees, D., Aldinger, C., Reagan, W., Singh, J., Kerlin, R., Kane, C., Bagley, S., Hayward, C, Loy, J., O'Brien, P. and Francone, O.L. (2006): A critical role for peroxisomal proliferator-activated receptor-α nuclear receptors in the development of cardiomyocyte degeneration and necrosis. Am. J. Pathol., 169, 750-760.
8. Reddy, J.K. and Hashimoto, T. (2001): Peroxisomal β-oxidation and peroxisome proliferator-activated receptor α: an adaptive metabolic system. Annu. Rev. Nutr, 21, 193-230.
9. Schoonjans, K., Staels, B. and Auwerx, J. (1996): Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid. Res., 37, 907-925.
10. Uchida, Y., Izai, K., Orii, T. and Hashimoto, T. (1992): Novel fatty acid β-oxidation enzymes in rat liver mitochondria. II. Purification and properties of enoyl-coenzyme A (CoA) hydratase/3-hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase trifunctional protein. J. Biol. Chem., 267, 1034-1041.
11. van der Vusse, G.J., Glatz, J.F., Stam, H.C. and Reneman, R.S. (1992): Fatty acid homeostasis in the normoxic and ischemic heart. Physiol. Rev, 72, 881-940.