Understanding cost-effectiveness in the ICU

Seminars in Respiratory and Critical Care Medicine

Volumn 31, Issue 1, 2010, Pages 13-18

  Zilberberg, Marya D ^a,b  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b EviMed Research Group LLC   (United States)

Author keywords

Cost effectiveness; Cost utility; Health care costs; Intensive care unit (ICU)

Indexed keywords

COST EFFECTIVENESS ANALYSIS; COST UTILITY ANALYSIS; ECONOMIC ASPECT; HEALTH CARE COST; HEALTH CARE DELIVERY; INTENSIVE CARE UNIT; LENGTH OF STAY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR; REVIEW; SENSITIVITY ANALYSIS;

COST-BENEFIT ANALYSIS; DELIVERY OF HEALTH CARE; EFFICIENCY, ORGANIZATIONAL; HEALTH CARE COSTS; HUMANS; INTENSIVE CARE; INTENSIVE CARE UNITS; UNITED STATES;

EID: 76749094140     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0029-1246282     Document Type: Review

References (39)

1. Epstein S K. Etiology of extubation failure and the predictive value of the rapid shallow breathing index. Am J Respir Crit Care Med 1995 152 (2) 545-549
2. Esteban A, Frutos F, Tobin M J. et al, Spanish Lung Failure Collaborative Group. A comparison of four methods of weaning patients from mechanical ventilation. N Engl J Med 1995 332 345-350
3. Ely E W., Baker A M., Dunagan D P. et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med 1996 335 1864-1869
4. Kollef M H., Shapiro S D., Silver P et al. A randomized, controlled trial of protocol-directed versus physician-directed weaning from mechanical ventilation. Crit Care Med 1997 25 567-574
5. Kress J P., Pohlman A S., O'Connor M F., Hall J B. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000 342 1471-1477
6. Stewart T E., Meade M O., Cook D J. et al, Pressure- and Volume-Limited Ventilation Strategy Group. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. N Engl J Med 1998 338 355-361
7. Rivers E, Nguyen B, Havstad S et al, Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001 345 1368-1377
8. Annane D, Sébille V, Charpentier C et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002 288 862-871
9. van den Berghe G, Wouters P, Weekers F et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001 345 1359-1367
10. Connors A F. Jr, Speroff T, Dawson N V. et al, SUPPORT Investigators. The effectiveness of right heart catheterization in the initial care of critically ill patients. JAMA 1996 276 889-897
11. Hébert P C., Wells G, Blajchman M A. et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999 340 409-417
12. Institute of Medicine. To Err Is Human: Building a Safer Health System. Washington, DC National Academy Press 1999
13. McGlynn E A., Asch S M., Adams J et al. The quality of health care delivered to adults in the United States. N Engl J Med 2003 348 2635-2645
14. OECD health data 2009frequently requested data. Available at: http://www.oecd.org/dataoecd/48/4/33727936.pdf Accessed November 27, 2006
15. Schwartz K, Vilquin J T. Building the translational highway: toward new partnerships between academia and the private sector. Nat Med 2003 9 493-495
16. Martin G S., Mannino D M., Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003 348 1546-1554
17. Dombrovskiy V Y., Martin A A., Sunderram J, Paz H L. Facing the challenge: decreasing case fatality rates in severe sepsis despite increasing hospitalizations. Crit Care Med 2005 33 2555-2562
18. Dombrovskiy V Y., Martin A A., Sunderram J, Paz H L. Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003. Crit Care Med 2007 35 1244-1250
19. Zilberberg M D., de Wit M, Pirone J R., Shorr A F. Growth in adult prolonged acute mechanical ventilation: implications for healthcare delivery. Crit Care Med 2008 36 1451-1455
20. Chelluri L, Im K A., Belle S H. et al. Long-term mortality and quality of life after prolonged mechanical ventilation. Crit Care Med 2004 32 61-69
21. Angus D C., Clermont G, Linde-Zwirble W T. et al, NO-06 Investigators. Healthcare costs and long-term outcomes after acute respiratory distress syndrome: a phase III trial of inhaled nitric oxide. Crit Care Med 2006 34 2883-2890
22. Hopkins R O., Jackson J C. Long-term neurocognitive function after critical illness. Chest 2006 130 869-878
23. Hopkins R O., Weaver L K., Collingridge D, Parkinson R B., Chan K J., Orme J F. Jr. Two-year cognitive, emotional, and quality-of-life outcomes in acute respiratory distress syndrome. Am J Respir Crit Care Med 2005 171 340-347
24. Van Pelt D C., Milbrandt E B., Qin L et al. Informal caregiver burden among survivors of prolonged mechanical ventilation. Am J Respir Crit Care Med 2007 175 167-173
25. Halpern N A., Pastores S M., Greenstein R J. Critical care medicine in the United States 19852000: an analysis of bed numbers, use, and costs. Crit Care Med 2004 32 1254-1259
26. Understanding costs and cost-effectiveness in critical care: report from the second American Thoracic Society workshop on outcomes research. Am J Respir Crit Care Med 2002 165 540-550
27. Weinstein M C., Siegel J E., Gold M R., Kamlet M S., Russell L B. Recommendations of the panel on cost-effectiveness in health and medicine. JAMA 1996 276 1253-1258
28. Angus D C., Linde-Zwirble W T., Clermont G et al, PROWESS Investigators. Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med 2003 31 1-11
29. Shorr A F., Susla G M., Kollef M H. Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit Care Med 2004 32 137-143
30. Shorr A F., Zilberberg M D., Kollef M H. Cost-effectiveness analysis of a silver-coated endotracheal tube to reduce the incidence of ventilator- associated pneumonia. Infect Control Hosp Epidemiol 2009 30 759-763
31. Zilberberg M D., Kothari S, Shorr A F. Cost-effectiveness of micafungin as an alternative to fluconazole empiric treatment of suspected ICU-acquired candidemia among patients with sepsis: a model simulation. Crit Care 2009 13 R94
32. Talmor D, Shapiro N, Greenberg D, Stone P W., Neumann P J. When is critical care medicine cost-effective? A systematic review of the cost-effectiveness literature. Crit Care Med 2006 34 2738-2747
33. Price K F. Pricing Medicare's diagnosis-related groups: charges versus estimated costs. Health Care Financing Review, Fall 1989. Available at: http://findarticles.com/p/articles/mi-m0795/is-n1-v11/ai-9338473 Accessed September 18, 2009
34. Warren D K., Shukla S J., Olsen M A. et al. Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med 2003 31 1312-1317
35. Dasta J F., McLaughlin T P., Mody S H., Piech C T. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Crit Care Med 2005 33 1266-1271
36. Kahn J M., Rubenfeld G D., Rohrbach J, Fuchs B D. Cost savings attributable to reductions in intensive care unit length of stay for mechanically ventilated patients. Med Care 2008 46 1226-1233
37. Huang D T., Clermont G, Dremsizov T T., Angus D C., ProCESS Investigators. Implementation of early goal-directed therapy for severe sepsis and septic shock: a decision analysis. Crit Care Med 2007 35 2090-2100
38. Pronovost P J., Needham D M., Waters H et al. Intensive care unit physician staffing: financial modeling of the Leapfrog standard. Crit Care Med 2004 32 1247-1253
39. Kahn J M., Kramer A A., Rubenfeld G D. Transferring critically ill patients out of hospital improves the standardized mortality ratio: a simulation study. Chest 2007 131 68-75