Steroids and triterpenoid from the fruit bodies of Ganoderma lucidum and their cytotoxic activity

Natural Product Sciences

Volumn 15, Issue 3, 2009, Pages 173-179

  Lee, Joon Seok ^a   Lee, Mi Kyoung ^a   Hung, Tran Manh ^a   Lee, Ik Soo ^b   Min, Byung Sun ^a   Bae, KiHwan ^b  

^a Catholic University of Daegu   (South Korea)

^b Chungnam National University   (South Korea)

Author keywords

Cytotoxic activity; Ganoderic acid Sz; Ganoderma lucidum; Lanostadiene triterpene; Polyporaceae

Indexed keywords

9(11) DEHYDROERGOSTEROL PEROXIDE; ERGOSTEROL; ERGOSTEROL PEROXIDE; GANODERMA LUCIDUM EXTRACT; GANODERMANONTRIOL; STELLA STEROL; STEROID; TRITERPENOID; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN HL 60; CELL STRAIN LLC; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; FRUIT; GANODERMA LUCIDUM; HUMAN; HUMAN CELL; PHYSICAL CHEMISTRY; SPECTROSCOPY;

EID: 76649140145     PISSN: 12263907     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Arisawa, M., Fujita, A., Gaga, M., Fukumura, H., Hayashi, T., Shimizu, M., and Motita, N., Three new lanostanoids from Ganoderma lucidum. J. Nat. Prod., 49, 621 (1986).
2. Canjun, L.I., Ganoderic acid Sz, a new lanostanoid from the mushroom Ganoderma lucidum. Nat. Prod. Res., 19, 461-465(2005).
3. Chen, N.H., Liu, J.Z., and Zhong, J.J. Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression. J. Pharmacol. Sci., 108, 212-216 (2008).
4. Cheung, W.M., Hui, W.S., Chu, P.W., Chiu, S.W., and Ip, N.Y., Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Letters, 486, 291-296 (2000).
5. Fujita, A., Arisawa, M., Saga, M., Hayashi, T., and Morita, N., Two lanostanoids from Ganoderma lucidum. J. Nat. Prod., 49, 1122-1125 (1986).
6. Gao, Y., Zhou, S., Liang, W., and Huang, M., Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol. Invest., 32, 201 (2003).
7. Hu, H.B., Ahn, N.S., Yang, X.L., Lee, Y.S., and Kang, K.S., Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Intl. J. Cancer, 102, 250-253 (2002).
8. Jeffrey, L. and Wright, C., Minor and trace sterols of Dunaliella tertiolecta. Phytochemistry, 20, 2403-2405 (1981).
9. Joachim, R. and Wilfried, A., Constituents of the fungi Daedalea quercina and Daedaleopsis confragosa var. tricolor. Phytochemistry, 54, 757-762 (2000).
10. Kimura, Y., Taniguchi, M., and Baba, K., Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res., 22, 3309-3318 (2002).
11. Kobori, M., Yoshida, M., Ohnishi-Kameyama, M., Takei, T., and Shinmoto, H., 5α,8α-Epidioxy-22E-ergosta-6,9(11),22-trien-3β-ol from an edible mushroom suppresses growth of HL60 Leukemia and HT29 colon adenocarcinoma cells. Biol. Pharm. Bull., 29, 755-759 (2006).
12. Kubo, M., Matsuda, H., Nogami, M., Arichi, S., and Takahashi, T., Ganoderma lucidum Effects on disseminated intravascular coagulation. Immunol. Invest., 32, 201-215 (2003).
13. Kubota, T., Asaka, Y., and Miura, H., Structures of ganoderic acid A and B, two new lanostane type bitter triterpenes from Ganoderma lucidum (Fr.) Karst. Helv. Chim. Acta., 65, 611-619 (1982).
14. Lin, Z.B., Modern Research of Ganoderma lucidum (second ed.). Beijing Medical University Press 219-283 (2001).
15. Lin, Z.B., Zhou, J.H., Recent Advances in Chinese Herbal Drugs-Actions and Uses. Scientific Publishing House 133-140 (1991).
16. Lu, H.M., Kyo, E., Uesaka, T., Katoh, O., and Watanabe, H., A watersoluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats. Oncol Rep., 10, 375-379 (2003).
17. Lu, Q.Y., Jin, Y.S., Zhang, Q., Zhang, Z., Heber, D., and Go, V.L., Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro. Cancer Lett., 216, 9-20 (2004).
18. Min, B.S., Nakamura, N., Miyashiro, H., Bae, K.H., and Hattori, M., Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity againsst HIV-1 Protease. Chem. Pharm. Bull., 46, 1607-1612 (1998).
19. Miyazaki, T. and Nishijima, M., Studies on fungal polysaccharides. XXVII. Structural examination of a water-soluble, antitumor polysaccharide of Ganoderma lucidum. Chem. Pharm. Bull., 29, 3611-3616 (1981).
20. Mosmann, T.J., Rapid colorimetric assay for cellular growth and survival application to proliferation and cytotoxicicity assays. J. Immunol. Methods, 65, 55-63 (1983).
21. Rubinstein, L.J. and Goad, A.D., The 220 MHz NMR spectrum of phytosterols. Phytochemistry, 15, 195-200 (1976).
22. Sliva, D., Labarrere, C., Slivova, V., Sedlak, M., Lloyd, F.P.Jr., and Ho, N.W., Ganoderma lucidum suppresses motility of highly invasive breast and prostate cancer cells. Biochem. Biophys. Res. Commun., 298, 603-612 (2002).
23. Thyagarajan, A., Jiang, J., Hopf, A., Adamec, J., and Sliva, D., Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. Intl. J. Mol. Med., 18, 657-664 (2006).
24. Wang, G., Zhao, J., Liu, J.W., Huang, Y.P., Zhong, J.J., and Tang, W., Enhancement of IL-2 and IFN-gamma expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo. Int. Immunopharmacol. , 7, 864-870 (2007).
25. Wang, S.Y., Hsu, M.L., and Hsu, H.C., The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int. J. Cancer, 70, 699-705 (1997).
26. Wasser, S.P. and Weis, A.L., Medicinal properties of substances occurring in higher Basidiomycete mushrooms: current perspective (review). Int. J. Med. Mush., 1, 31-62 (1999).
27. Wu, Q.P., Xie, Y.Z., Li, S.Z, La Pierre, D.P., Deng, Z., and Chen, Q., Tumor cell adhesion and integrin expression affected by Ganoderma lucidum. Enzyme Microb. Tech., 40, 32-4126 (2006).