Rituximab was effective on refractory thrombotic thrombocytopenic purpura but induced a flare of hemophagocytic syndrome in a patient with systemic lupus erythematosus

Modern Rheumatology

Volumn 20, Issue 1, 2010, Pages 81-85

  Kamiya, Kuniyoshi ^a   Kurasawa, Kazuhiro ^a   Arai, Satoko ^a   Maezawa, Reika ^a   Hanaoka, Ryosuke ^a   Kumano, Kotaro ^a   Fukuda, Takeshi ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Hemophagocytic syndrome; Regulatory B cell; Rituximab; Systemic lupus erythematosus; Thrombotic thrombocytopenic purpura

Indexed keywords

ANTINUCLEAR ANTIBODY; CORTICOSTEROID; CYCLOPHOSPHAMIDE; GLUCOCORTICOID; PREDNISOLONE; RITUXIMAB; RO ANTIBODY; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE; CASE REPORT; DRUG DOSE REDUCTION; DRUG EFFICACY; DYSPNEA; EDEMA; ENZYME ACTIVITY; FEMALE; HEMOPHAGOCYTIC SYNDROME; HUMAN; HUMAN TISSUE; INTERSTITIAL PNEUMONIA; LABORATORY TEST; LUNG ALVEOLITIS; LUNG BIOPSY; LUNG INFILTRATE; LYMPHOCYTE DEPLETION; MALAISE; NEPHRITIS; PHOTOSENSITIVITY; PLASMAPHERESIS; PRIORITY JOURNAL; SALIVATION; SIALOADENITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOTIC THROMBOCYTOPENIC PURPURA; XEROSTOMIA;

ADAM PROTEINS; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; B-LYMPHOCYTES; COMBINED MODALITY THERAPY; CYCLOPHOSPHAMIDE; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MIDDLE AGED; PLASMA EXCHANGE; PURPURA, THROMBOTIC THROMBOCYTOPENIC;

EID: 76649137247     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-009-0231-8     Document Type: Article

References (27)

1. PE Lipsky 2001 Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity Nat Immunol 2 764 766 10.1038/ni0901-764 1:CAS:528: DC%2BD3MXmsFeju7s%3D 11526379 (Pubitemid 34906430)
2. F Martin AC Chan 2006 B cell immunobiology in disease: evolving concepts from the clinic Annu Rev Immunol 24 467 496 10.1146/annurev.immunol.24.021605. 090517 1:CAS:528:DC%2BD28XkvFSqtL0%3D 16551256
3. A Mizoguchi AK Bhan 2006 A case for regulatory B cells J Immunol 176 2 705 710 1:CAS:528:DC%2BD28Xht1CrsA%3D%3D 16393950
4. SM Anderton S Fillatreau 2008 Activated B cells in autoimmune diseases: the case for a regulatory role Nat Clin Pract Rheumatol 4 657 666 10.1038/ncprheum0950 1:CAS:528:DC%2BD1cXhsVent7rM 19037227
5. GJ Silverman S Weisman 2003 Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy Arthritis Rheum 48 1484 1492 10.1002/art.10947 1:CAS:528:DC%2BD3sXltlSgtbk%3D 12794814 (Pubitemid 36682354)
6. R Eisenberg D Albert 2006 B-cell targeted therapies in rheumatoid arthritis and systemic lupus erythematosus Nat Clin Pract Rheumatol 2 20 27 10.1038/ncprheum0042 1:CAS:528:DC%2BD28Xis1yjurc%3D 16932648 (Pubitemid 43153645)
7. I Gunnarsson B Sundelin T Jónsdóttir SH Jacobson EW Henriksson RF van Vollenhoven 2007 Histopathologic and clinical outcome of rituximab treatment in patients with cyclophosphamide-resistant proliferative lupus nephritis Arthritis Rheum 56 1263 1272 10.1002/art.22505 1:CAS:528:DC%2BD2sXltFKgs7s%3D 17393458 (Pubitemid 46608651)
8. M Tokunaga K Saito D Kawabata Y Imura T Fujii S Nakayamada, et al. 2007 Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system Ann Rheum Dis 66 470 475 10.1136/ard.2006.057885 1:CAS:528:DC%2BD2sXkvFeks7w%3D 17107983 (Pubitemid 46580466)
9. C Lindholm K Börjesson-Asp K Zendjanchi AC Sundqvist A Tarkowski M Bokarewa 2008 Long term clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus J Rheumatol 35 5 826 833 18398943
10. JN George 2006 Clinical practice. Thrombotic thrombocytopenic purpura N Engl J Med 354 1927 1935 10.1056/NEJMcp053024 1:CAS:528:DC%2BD28XksVGiurk%3D 16672704 (Pubitemid 43872694)
11. JN George RD Woodson JE Kiss K Kojouri SK Vesely 2006 Rituximab therapy for thrombotic thrombocytopenic purpura: a proposed study of the Transfusion Medicine/Hemostasis Clinical Trials Network with a systematic review of rituximab Treatment of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in therapy for immune-mediated disorders J Clin Apher 21 49 56 10.1002/jca.20091 16619232
12. AA Shah JP Higgins EF Chakravarty 2007 Thrombotic microangiopathic hemolytic anemia in a patient with SLE: diagnostic difficulties Nat Clin Pract Rheumatol 3 6 357 10.1038/ncprheum0511 (Pubitemid 46864890)
13. TB Niewold D Alpert CR Scanzello SA Paget 2006 Rituximab treatment of thrombotic thrombocytopenic purpura in the setting of connective tissue disease J Rheumatol 33 1194 1196 16755668
14. N Limal P Cacoub D Sène I Guichard JC Piette 2008 Rituximab for the treatment of thrombotic thrombocytopenic purpura in systemic lupus erythematosus Lupus 17 69 71 10.1177/0961203307083479 1:STN:280: DC%2BD2sjlt1WrsA%3D%3D 18089688
15. P Letchumanan HJ Ng LH Lee J Thumboo 2009 A comparison of thrombotic thrombocytopenic purpura in an inception cohort of patients with and without systemic lupus erythematosus Rheumatology 48 399 403 10.1093/rheumatology/ken510 19202160
16. JL Moake 2002 Thrombotic microangiopathies N Engl J Med 347 589 600 10.1056/NEJMra020528 1:CAS:528:DC%2BD38Xmt1yit7Y%3D 12192020 (Pubitemid 34898873)
17. T Miyamura H Watanabe S Takahama K Sonomoto M Nakamura H Ando, et al. 2008 Thrombotic thrombocytopenic purpura in patients with systemic lupus erythematosus Nihon Rinsho Meneki Gakkai Kaishi 31 159 165 18587226 Japanese
18. O Lambotte M Khellaf H Harmouche B Bader-Meunier V Manceron C Goujard, et al. 2006 Characteristics and long-term outcome of 15 episodes of systemic lupus erythematosus-associated hemophagocytic syndrome Medicine 85 169 182 10.1097/01.md.0000224708.62510.d1 16721259 (Pubitemid 43833015)
19. S Kumakura H Ishikura M Kondo Y Murakawa J Masuda S Kobayashi 2004 Autoimmune-associated hemophagocytic syndrome Mod Rheumatol 14 205 215 10.1007/s10165-004-0293-6 17143676
20. G Zandman-Goddard Y Shoenfeld 2007 Ferritin in autoimmune diseases Autoimmun Rev 6 457 463 10.1016/j.autrev.2007.01.016 1:CAS:528: DC%2BD2sXhtV2mu7jI 17643933 (Pubitemid 47079115)
21. A Bruns S Bläss G Hausdorf GR Burmester F Hiepe 2000 Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus Arthritis Rheum 43 2307 2315 10.1002/1529-0131(200010)43:10<2307::AID-ANR19>3.0.CO;2-J 1:CAS:528:DC%2BD3cXnslWjsL0%3D 11037891 (Pubitemid 30783150)
22. V Urbonaviciute BG Fürnrohr S Meister L Munoz P Heyder F De Marchis, et al. 2008 Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE J Exp Med 205 3007 3018 10.1084/jem.20081165 1:CAS:528:DC%2BD1MXosFCl 19064698
23. T Matsushita K Yanab JD Bouaziz M Fujimoto TF Tedder 2008 Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression J Clin Invest 118 3420 3430 1:CAS:528:DC%2BD1cXht1ChsrjM 18802481
24. M Goetz R Atrey M Ghalibafian PR Galle MF Neurath 2007 Exacerbation of ulcerative colitis after rituximab salvage therapy Inflamm Bowel Dis 13 1365 1368 10.1002/ibd.20215 17604367 (Pubitemid 350206846)
25. S Dass EM Vital P Emery 2007 Development of psoriasis after B cell depletion with rituximab Arthritis Rheum 56 2715 2718 10.1002/art.22811 1:CAS:528:DC%2BD2sXhtVWqu7bE 17665440 (Pubitemid 47237290)
26. EM Kfoury Baz AR Mikati NA Kanj 2002 Reactive hemophagocytic syndrome associated with thrombotic thrombocytopenic purpura during therapeutic plasma exchange Ther Apher 6 159 162 10.1046/j.1526-0968.2002.00362.x 11982958 (Pubitemid 34507308)
27. T Yamada Y Handa T Kamikawa H Machino K Suzuki K Miyata 2006 A case of systemic lupus erythematosus associated with thrombotic thrombocytopenic purpura and hemophagocytic syndrome Nihon Rinsho Meneki Gakkai Kaishi 29 384 388 17202756 Japanese