The first autopsy case of pandemic influenza (A/H1N1pdm) virus infection in Japan: Detection of a high copy number of the virus in type II alveolar epithelial cells by pathological and virological examination

Japanese Journal of Infectious Diseases

Volumn 63, Issue 1, 2010, Pages 67-71

  Nakajima, Noriko ^a   Hata, Satoru ^b   Sato, Yuko ^a   Tobiume, Minoru ^a   Katano, Harutaka ^a   Kaneko, Keiko ^a   Nagata, Noriyo ^a   Kataoka, Michiyo ^a   Ainai, Akira ^a   Hasegawa, Hideki ^a   Tashiro, Masato ^a   Kuroda, Makoto ^a   Odai, Tamami ^b   Urasawa, Nobuyuki ^b   Ogino, Tomoyoshi ^b   Hanaoka, Hiroaki ^b   Watanabe, Masahide ^b   Sata, Tetsutaro ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b NAGANO RED CROSS HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; METHYLPREDNISOLONE; MONOCYTE CHEMOTACTIC PROTEIN 1; SIVELESTAT; VIRUS RNA;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ARTICLE; ARTIFICIAL VENTILATION; ASTHMA; ATOPIC DERMATITIS; AUTOPSY; BODY MASS; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONGESTIVE CARDIOMYOPATHY; DIABETES MELLITUS; DIARRHEA; DYSPNEA; ELECTRON MICROSCOPY; HEART FAILURE; HUMAN; IMMUNOHISTOCHEMISTRY; INFLUENZA; INFLUENZA VIRUS A H1N1; INTUBATION; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; MALE; MULTIPLE ORGAN FAILURE; OBESITY; PANDEMIC; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY FAILURE; THORAX RADIOGRAPHY; VIROLOGY; VIRUS DETECTION; VIRUS INFECTION; VIRUS ISOLATION; VIRUS PARTICLE;

EID: 76649133449     PISSN: 13446304     EISSN: None     Source Type: Journal    
DOI: 10.7883/yoken.63.67     Document Type: Article

References (16)

1. Centers for Disease, Control and Prevention (2009): Intensive-care patients with severe novel influenza A(H1N1) virus infection - Michigan. Morbid. Mortal. Wkly. Rep., 58, 749-752.
2. Centers for Disease, Control and Prevention (2009): Neurologic complications associated with novel influenza A (H1N1) virus infection in children---Dallas, Texas. Morbid. Mortal. Wkly. Rep., 58, 773-778.
3. Perez-Padilla, R., de la Rosa-Zamboni, D., Ponce de Leon, S., et al. (2009): Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N. Engl. J. Med., 361, 680-689.
4. Ministry of Health, Labour and Welfare, Japan: Situation of H1N1 in Japan. Online at .
5. Mauda, T., Hajjar, L.A., Callegari, G.D., et al. (2010): Lung pathology in fatal novel human influenza A (H1N1) infection. Am. J. Respir. Crit. Care Med., 181, 72-79.
6. Gill, J.R., Sheng, Z.M., Ely., S.F., et al. (2010): Pulmonary pathologic findings of fatal 2009 pandemic influenza A/H1N1 viral infections. Arch. Pathol. Lab. Med., 134 (published on line).
7. Chen, Z., Sahashi, Y., Matsuo, K., et al. (1998): Comparison of the ability of viral protein-expressing plasmid DNAs to protect against influenza. Vaccine, 16, 1544-1549.
8. Nakajima, N., Ionescu, P., Sato, Y., et al. (2003): In situ hybridization AT-tailing with catalyzed signal amplification for sensitive and specific in situ detection of human immunodeficiency virus-1 mRNA in formalinfixed and paraffin-embedded tissues. Am. J. Pathol., 162, 381-389.
9. Nakajima, N., Asahi-Ozaki, Y., Nagata, N., et al. (2003): SARS coronavirus-infected cells in lung detected by new in situ hybridization technique. Jpn. J. Infect. Dis., 56, 139-141.
10. Liem, N.T., Nakajima, N., Phat, L.P., et al. (2008): H5N1-infected cells in lung with diffuse alveolar damage in exudative phase from a fatal case in Vietnam. Jpn. J. Infect. Dis., 61, 157-160.
11. Shinya, K., Ebina, M., Ono, M., et al. (2006): Avian flu: influenza receptors in the human airway. Nature, 440, 435-436.
12. Gambaryan, A.S., Tuzikov, A.B., Piskarev, V.E., et al. (1997): Specification of receptor-binding phenotypes of influenza virus isolates from different hosts using synthetic sialyglycopolymers: non-egg-adapted human H1 and H3 influenza A and influenza B viruses share a common high binding affinity for 6′-sialyl (N-acetyllactosamine). Virology, 232, 345-350.
13. Katano, H., Ito, H., Suzuki, Y., et al. (2009): Detection of Merkel cell polyomavirus in Merkel cell carcinoma and Kaposi's sarcoma. J. Med. Virol., 81, 1951-1958.
14. Kuramochi, H., Hayashi, K., Uchida, K., et al. (2006): Vascular endothelial growth factor messenger RNA expression level is preserved in liver metastases compared with corresponding primary colorectal cancer. Clin. Cancer Res., 12, 29-33.
15. Tobiume, M., Sato, Y., Katano, H., et al. (2009): Rabies virus dissemination in neural tissues of autopsy cases due to rabies imported into Japan from Philippines: immunohistochemistry. Pathol. Int., 59, 555-566.
16. Nagata, N., Iwata, N., Hasegawa, H., et al. (2008): Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice. Am. J. Pathol., 172, 1625-1637.