The effects of omalizumab on IgE-induced cytokine synthesis by asthmatic airway smooth muscle cells

Annals of Allergy, Asthma and Immunology

Volumn 104, Issue 2, 2010, Pages 152-160

  Roth, Michael ^a   Tamm, Michael ^a  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OMALIZUMAB; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ASTHMA; CELL ISOLATION; CELL SECRETION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOBLOTTING; INFLAMMATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY EPITHELIUM; SMOOTH MUSCLE FIBER;

EID: 76649105497     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/j.anai.2009.11.022     Document Type: Article

References (30)

1. Barnes PJ. The cytokine network in asthma and chronic obstructive pulmonary disease. J Clin Invest. 2008;118:3546 -3556.
2. Tliba O, Amrani Y, Panettieri RA Jr. Is airway smooth muscle the "missing link" modulating airway inflammation in asthma? Chest. 2008; 133:236 -242.
3. Laitinen T, Kauppi P, Ignatius J, et al. Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population. Hum Mol Genet. 1997;6:2069 -2076.
4. Platts-Mills TA, Erwin EA, Allison AB, et al. The relevance of maternal immune responses to inhalant allergens to maternal symptoms, passive transfer to the infant, and development of antibodies in the first 2 years of life. J Allergy Clin Immunol. 2003;111:123-130.
5. Chang TW. Developing antibodies for targeting immunoglobulin and membrane-bound immunoglobulin E. Allergy Asthma Proc. 2006;27: S7-S14.
6. Fahy JV. Anti-IgE: lessons learned from effects on airway inflammation and asthma exacerbation. J Allergy Clin Immunol. 2006;117: 1230-1232.
7. Hakonarson H, Carter C, Kim C, Grunstein MM. Altered expression and action of the low-affinity IgE receptor FcεRII (CD23) in asthmatic airway smooth muscle. J Allergy Clin Immunol. 1999;104:575-584.
8. Gounni AS, Wellemans V, Yang J, et al. Human airway smooth muscle cells express the high affinity receptor for IgE (Fcε RI): a critical role of Fc epsilon RI in human airway smooth muscle cell function. J Immunol. 2005;175:2613-2621.
9. Rosenwasser LJ, Meng J. Anti-CD23. Clin Rev Allergy Immunol. 2005; 29:61-72.
10. Holgate S, Casale T, Wenzel S, Bousquet J, Deniz Y, Reisner C. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. J Allergy Clin Immunol. 2005;115:459-465.
11. Gounni AS. The high-affinity IgE receptor (FcεRI): a critical regulator of airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2006;291:L312-L321.
12. Tliba O, Panettieri RA Jr. Regulation of inflammation by airway smooth muscle. Curr Allergy Asthma Rep. 2008;8:262-268.
13. D'Amato G, Bucchioni E, Oldani V, Canonica W. Treating moderateto-severe allergic asthma with a recombinant humanized anti-IgE monoclonal antibody (omalizumab). Treat Respir Med. 2006;5:393-398.
14. Johnson PR, Armour CL, Carey D, Black JL. Heparin and PGE2 inhibit DNA synthesis in human airway smooth muscle cells in culture. Am J Physiol. 1995;269:L514 -L519.
15. D'Amato G, Salzillo A, Piccolo A, D'Amato M, Liccardi G. A review of anti-IgE monoclonal antibody (omalizumab) as add on therapy for severe allergic (IgE-mediated) asthma. Ther Clin Risk Manag. 2007;3: 613-619.
16. Bousquet J, Cabrera P, Berkman N, et al. The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma. Allergy. 2005;60:302-308.
17. Tunon de Lara JM. Immunoglobulins E and inflammatory cells. Rev Mal Respir. 1996;13:27-36.
18. Hakonarson H, Grunstein MM. Autologously up-regulated Fc receptor expression and action in airway smooth muscle mediates its altered responsiveness in the atopic asthmatic sensitized state. Proc Natl Acad Sci U S A. 1998;95:5257-5262.
19. Oliver BG, Johnston SL, Baraket M, et al. Increased proinflammatory responses from asthmatic human airway smooth muscle cells in response to rhinovirus infection. Respir Res. 2006;7:71.
20. Burgess JK, Carlin S, Pack RA, et al. Detection and characterization of OX40 ligand expression in human airway smooth muscle cells: a possible role in asthma. J Allergy Clin Immunol. 2004;113:683- 689.
21. Brightling C, Berry M, Amrani Y. Targeting TNF-α: a novel therapeutic approach for asthma. J Allergy Clin Immunol. 2008;121:5-10.
22. Gomez G, Jogie-Brahim S, Shima M, Schwartz LB. Omalizumab reverses the phenotypic and functional effects of IgE-enhanced FcεRI on human skin mast cells. J Immunol. 2007;179:1353-1361.
23. Ammit AJ, Moir LM, Oliver BG, et al. Effect of IL-6 trans-signaling on the pro-remodeling phenotype of airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;292:L199 -L206.
24. Lopuhaä CE, Out TA, Jansen HM, Aalberse RC, van der Zee JS. Allergen-induced bronchial inflammation in house dust mite-allergic patients with or without asthma. Clin Exp Allergy. 2002;32:1720-1727.
25. Maneechotesuwan K, Essilfie-Quaye S, Kharitonov SA, Adcock IM, Barnes PJ. Loss of control of asthma following inhaled corticosteroid withdrawal is associated with increased sputum interleukin-8 and neutrophils. Chest. 2007;132:98-105.
26. Govindaraju V, Michoud MC, Al-Chalabi M, Ferraro P, Powell WS, Martin JG. Interleukin-8: novel roles in human airway smooth muscle cell contraction and migration. Am J Physiol Cell Physiol. 2006;291: C957-C965.
27. Pease JE, Sabroe I. The role of interleukin-8 and its receptors in inflammatory lung disease: implications for therapy. Am J Respir Med. 2002;1:19 -25.
28. Abramson J, Licht A, Pecht I. Selective inhibition of the Fc ε RI-induced de novo synthesis of mediators by an inhibitory receptor. EMBO J. 2006;25:323-334.
29. Chacón P, Vega A, Monteseirín J, et al. Induction of cyclooxygenase-2 expression by allergens in lymphocytes from allergic patients. Eur J Immunol. 2005;35:2313-2324.
30. Li H, Chehade M, Liu W, Xiong H, Mayer L, Berin MC. Allergen-IgE complexes trigger CD23-dependent CCL20 release from human intestinal epithelial cells. Gastroenterology. 2007;133:1905-1915.