Oral baclofen administration in persons with chronic spinal cord injury does not prevent the protective effects of spasticity on body composition and glucose homeostasis

Spinal Cord

Volumn 48, Issue 2, 2010, Pages 160-165

  Gorgey, A S ^a,b   Chiodo, A E ^b   Gater, D R ^a,c  

^a DEPARTMENT OF VETERANS AFFAIRS   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BIA; Body composition; Oral baclofen; SCI; Spasticity

Indexed keywords

BACLOFEN; GLUCOSE;

ADULT; ARTICLE; BODY COMPOSITION; BODY FLUID COMPARTMENT; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; DRUG EFFICACY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; HUMAN; IMPEDANCE; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTRACELLULAR FLUID; LABORATORY; MALE; PRIORITY JOURNAL; SPASTICITY; SPINAL CORD INJURY; UNITED STATES;

ADMINISTRATION, ORAL; ADULT; BACLOFEN; BLOOD GLUCOSE; BODY COMPOSITION; CROSS-SECTIONAL STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; FEMALE; GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; HUMANS; INSULIN; MALE; MUSCLE RELAXANTS, CENTRAL; MUSCLE SPASTICITY; SPINAL CORD INJURIES;

EID: 76649100105     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sc.2009.105     Document Type: Article

References (19)

1. Kocina P. Body composition of spinal cord injured adults. Sports Med 1997; 23: 48-60.
2. Bauman WA, Spungen AM. Disorders of carbohydrate and lipid metabolism in veterans with paraplegia or quadriplegia: a model of premature aging. Metabolism 1994; 43: 749-756.
3. Gorgey AS, Dudley GA. Skeletal muscle atrophy and increased intramuscular fat after incomplete spinal cord injury. Spinal Cord 2007; 45: 304-309.
4. Castro MJ, Apple Jr DF, Hillegass EA, Dudley GA. Influence of complete spinal cord injury on skeletal muscle cross-sectional area within the first 6 months of injury. Eur J Appl Physiol Occup Physiol 1999; 80: 373-378.
5. Buchholz AC, McGillivray CF, Pencharz PB. The use of bioelectric impedance analysis to measure fluid compartments in subjects with chronic paraplegia. Arch Phys Med Rehabil 2003; 84: 854-861.
6. Adams MM, Hicks AL. Spasticity after spinal cord injury. Spinal Cord 2005; 43: 577-586.
7. Gorgey AS, Dudley GA. Spasticity may defend skeletal muscle size and composition after incomplete spinal cord injury. Spinal Cord 2008; 42: 96-102.
8. Bennegard GM, Karlsson AK. Higher glucose uptake in paralyses spastic leg. Spinal Cord 2008; 46: 103-106.
9. Gorgey AS, Chiodo T, Zemper ED, Hornyak JE, Rodriguez GM, Gater DR. The relationship of spasticity to soft tissue body composition and the metabolic profile in persons with chronic motor complete spinal cord injury. J Spinal Cord Med (In Press).
10. Dario A, Tomei G. A benefit-risk assessment of baclofen in severe spinal spasticity. Drug Saf 2004; 27: 799-818.
11. BaumanWA, Kirshblum SC, Morrison NG, Cirnigliaro CM, Zhang RL, Spungen AM. Effect of low-dose baclofen administration on plasma insulin-like growth factor-I in persons with spinal cord injury. J Clin Pharmacol 2006; 46: 476-482.
12. Sato I, Arima H, Ozaki N, Ozaki N, Watanabe M, Goto M et al. Peripherally administered baclofen reduced food intake and body weight in db/db as well as diet-induced obese mice. FEBS Lett 2007; 581: 4857-4864.
13. Skold C. Spasticity in spinal cord injury: self- and clinically rated intrinsic fluctuations and intervention-induced changes. Arch Phys Med Rehabil 2000; 81: 144-149.
14. Skold C, Harms-Ringdahl K, Hultling C, Levi R, Seiger A. Simultaneous Ashworth measurements and electromyographic recordings in tetraplegic patients. Arch Phys Med Rehabil 1998; 79: 959-965.
15. Hornby TG, Heckman CJ, Harvey RL, Rymer WZ. Changes in voluntary torque and electromyographic activity following oral baclofen. Muscle Nerve 2004; 30: 784-795.
16. McCoy AA, Fox MA, Schaubel DE, Ayyangar RN. Weight gain in children with hypertonia of cerebral origin receiving intrathecal baclofen therapy. Arch Phys Med Rehabil 2006; 87: 1503-1508.
17. Jones LM, Legge M, Goulding A. Healthy body mass index values often underestimate body fat in men with spinal cord injury. Arch Phys Med Rehabil 2003; 84: 1068-1071.
18. Janssen YJ, Deurenberg P, Roelfsema F. Using dilution techniques and multifrequency bioelectrical impedance to assess both total body water and extracellular water at baseline and during recombinant human growth hormone (GH) treatment in GH-deficient adults. J Clin Endocrinol Metab 1997; 82: 3349-3355.
19. Van Loan MD. Bioelectrical impedance analysis to determine fatfree mass, total body water and body fat. Sports Med 1990; 10: 205-217.