Prediction of solubility of drugs and other compounds in organic solvents

Journal of Pharmaceutical Sciences

Volumn 99, Issue 3, 2010, Pages 1500-1515

  Abraham, Michael H ^a   Smith, Robert E ^b,c   Luchtefeld, Ron ^b   Boorem, Aaron J ^c   Lou, Rensheng ^d   Acree Jr , William E ^e  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c PARK UNIVERSITY   (United States)

^d UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^e UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

Distribution; Physicochemical properties; QSPR; Solubility; Structure property relationship (SPR)

Indexed keywords

1,2 DICHLOROETHANE; 2 BUTANONE; 2 PROPANOL; 3,4 DICHLOROBENZOIC ACID; 4 IODOBENZOIC ACID; ACETIC ACID ETHYL ESTER; ACETONE; ACETONITRILE; ALCOHOL; APOCYNIN; BUTANE; CARBON TETRACHLORIDE; CHLOROFORM; CHOLESTEROL; CHOLESTEROL ACETATE; DECANOL; DEHYDRODI(METHYL VANILLATE); DEHYDRODIVANILLIN; DIAPOCYNIN; DICHLOROMETHANE; DIMETHYL SULFOXIDE; HEXANE; METHANOL; N,N DIMETHYLFORMAMIDE; ORGANIC SOLVENT; PENTANE; PROPANOL; TOLUENE; UNCLASSIFIED DRUG; VANILLIN; WATER;

ARTICLE; DRUG SOLUBILITY; HYDROPHOBICITY; PARTITION COEFFICIENT; PHYSICAL CHEMISTRY; PREDICTION; ROOM TEMPERATURE; SOLUTE; SOLVATION; STRUCTURE ACTIVITY RELATION;

EID: 76649095963     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21922     Document Type: Article

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