Epidemiology of candidemia in oncology patients: A 6-year survey in a Portuguese central hospital

Medical Mycology

Volumn 48, Issue 2, 2010, Pages 346-354

  Sabino, R ^a,d   Verissima, C ^a   Brandao J ^a   Alves, C ^a   Parada, H ^a   Rosado, L ^a   Paixao E ^b   Videira, Z ^c   Tendeiro, T ^c   Sampaio, P ^d   Pais, C ^d  

^a Instituto Nacional de Sade Dr Ricardo Jorge   (Portugal)

^b ONSA Observatrio Nacional de Sade   (Portugal)

^c Instituto Portugus de Oncologia Prof Francisco Gentil   (Portugal)

^d UNIVERSITY OF MINHO   (Portugal)

Author keywords

Blood cultures; Cancer patients; Candidemia

Indexed keywords

CASPOFUNGIN; FLUCONAZOLE; ITRACONAZOLE; POSACONAZOLE; VORICONAZOLE;

ADOLESCENT; ADULT; AGED; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BREAST TUMOR; CANCER PATIENT; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CANDIDEMIA; CHILD; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FUNGAL STRAIN; FUNGUS ISOLATION; GASTROINTESTINAL TUMOR; HEALTH SURVEY; HEMATOLOGIC DISEASE; HUMAN; INCIDENCE; INFANT; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PORTUGAL; PRESCHOOL CHILD; RHODOTORULA; SACCHAROMYCES CEREVISIAE; SCHOOL CHILD; SOLID TUMOR; SPECIES DISTRIBUTION; UROGENITAL TRACT TUMOR;

CANDIDA; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; RHODOTORULA MUCILAGINOSA; SACCHAROMYCES CEREVISIAE;

EID: 76649093606     PISSN: 13693786     EISSN: 14602709     Source Type: Journal    
DOI: 10.3109/13693780903161216     Document Type: Article

References (44)

1. Perlroth J, Choi B, Spellberg B. Nosocomial fungal infections: epidemiology, diagnosis and treatment. Med Mycol 2007; 45: 321-346.
2. Wisplinghoff H, Seifert H, Tallent SM, e t al. Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities. Pediatr Infect Dis J 2003; 22: 686-691 (Pubitemid 36999643)
3. Wisplinghoff H, Seifert H, Wenzel RP, Edmond MB. Current trends in the epidemiology of nosocomial bloodstream infections in patients with hematological malignancies and solid neoplasms in hospitals in the United States. Clin Infect Dis 2003; 36: 1103-1110. (Pubitemid 36553108)
4. Kulberg BJ, Lashof AML. Epidemiology of opportunistic invasive mycoses. Eur J Med Res 2002; 7: 183-191.
5. Hajjeh RA, Sofair AN, Harrison LH, et al. Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population based active surveillance program. J Clin Microbiol 2004; 42: 1519-1527.
6. Peman J, Canton E, Gobernado M, and the Spanish ECMM Working Group on Candidemia . Epidemiology and antifungal susceptibility of Candida species isolated from blood: results of a 2-year multicentre study in Spain . Eur J Clin Microbiol Infect Dis 2004; 23: 1267-1275 .
7. Trick WE, Fridkin SK, Edwards JR, Hajjeh RA, Gaynes RP, National Nosocomial Infections Surveillance System Hospitals . Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1998-1999. Clin Infect Dis 2002; 35: 627-630 .
8. Wingard JR. Importance of C andida species other than C. albicans as pathogens in oncology patients. Clin Infect Dis 1995; 20: 115-125.
9. Pfaller MA. Nosocomial candidiais: emerging species, reservoirs, and modes of transmission. Clin Infect Dis 1996; 22: S89 - 94.
10. Chai YAL, Wang Y, Khoo AL, et al. Predominance of C andida tropicalis bloodstream infections in a Singapore teaching hospital. Med Mycol 2007; 45: 435-439 .
11. Lupetti A, Tavanti A, Davini P, et al. Horizontal transmission of Candida parapsilosis candidemia in a neonatal intensive care unit. J Clin Microbiol 2002; 40: 2363-2369 .
12. St-Germain G, Laverdiere M, Pelletier R, et al. Prevalence and antifungal susceptibility of 442 Candida isolates from blood and other normally sterile sites: results of a 2-year (1996 to 1998) multicenter surveillance study in Quebec, Canada. J Clin Microbiol 2001; 39: 949-953 .
13. Almirante B, Rodriguez D, Cuenca-Estrella M, et al. Epidemiology, risk factors and prognosis of Candida parapsilosis bloodstream infections: case-control population-based surveillance study of patients in Barcelona, Spain, from 2002 to 2003. J Clin Microbiol 2006; 44: 1681-1685 .
14. Abi-Said D, Anaissie E, Omrum U, et al. The epidemiology of hematogenous candidiasis caused by different Candida species. Clin Infect Dis 1997; 24: 1122-1128 . (Pubitemid 127774267)
15. Viscoli C, Girmenia C, Marinus A, e t al. Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG) of the European Organization for Research and Treatment of Cancer (EORTC). Clin Infect Dis 1999; 28: 1071-1079 .
16. Pasqualotto AC, Rosa DD, Medeiros LR, Severo LC. Candidaemia and cancer: patients are not all the same. BMC Infect Dis 2006; 6: 50-56 .
17. Ribeiro P, Sousa AB, Nunes O, e t al. Candidemia in acute leukemia patients. Supp Care Canc 1997; 5: 249-251 .
18. Almirante B, Rodriguez D, Park BJ, e t al. Epidemiology and predictors of mortality in cases of Candida bloodstream infection: results from population-based surveillance, Barcelona, Spain, from 2002 to 2003. J Clin Microbiol. 2005; 43: 1829-1835 .
19. Correia A, Sampaio P, Almeida J, Pais C. Study of molecular epidemiology of candidiasis in Portugal by PCR fi ngerprinting of Candida clinical isolates. J Clin Microbiol 2004; 42: 5899-5903 .
20. Sampaio JP, Gadanho M, Santos S, e t al. Polyphasic taxonomy of the basidiomycetous yeast genus Rhodosporidium: Rhodosporidium kratochvilovae and related anamorphic species. Int J Syst Evol Microbiol 2001; 51: 687-697 .
21. National Committee for Clinical Laboratory Standards. R eference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts - 2nd edn: Approved Standard M27-A2 2nd edn: Wayne, PA: NCCLS , 2002 .
22. Bedini A, Venturelli C, Mussini C, et al. Epidemiology of candidemia and antifungal susceptibility patterns in an Italian tertiary-care hospital. Clin Microbiol Infect 2006; 12: 75-80.
23. Diekema DJ, Messer SA, Hollis RJ, e t al. Evaluation of Etest and disk diffusion methods compared with broth microdilution antifungal susceptibility testing of clinical isolates of Candida spp. against posaconazole. J Clin Microbiol 2007; 45: 1974-1977 .
24. Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Reviews. 2007; 20: 133-163 .
25. Baixench MT, Aoun N, Desnos-Ollivier M, e t al. Acquired resistance to echinocandins in Candida albicans case report and review. J Antimicrob Chemother 2007; 59: 1076-1083 .
26. Costa-de-Oliveira S, Pina-Vaz C, Mendonca D, Goncalves Rodrigues A. A fi rst Portuguese epidemiological survey of fungaemia in a university hospital. Eur J Clin Microbiol Infect Dis 2008; 27: 365-374 .
27. Nucci M, Colombo AL. Risk factors for breakthrough candidemia. Eur J Clin Microbiol Infect Dis 2002; 21: 209-211 .
28. Raad I, Hanna H, Boktour M, e t al. Management of central venous catheters in patients with cancer and candidemia. Clin Infect Dis 2004; 38: 1119-1127 .
29. Tortorano AM, Kibbler C, Peman J, et al. Candidemia in Europe: epidemiology and resistance. Int J Antimicrob Agents 2006; 27: 359-366 .
30. Pasqualotto AC, Severo LC. The importance of central venous catheter removal in patients with candidemia: time to rethink our practice? Clin Microbiol Infect 2008; 14: 2-4 .
31. DiNubile MJ, Hille D, Sable CA, Kartsonis NA. Invasive candidiasis in cancer patients: observations from a randomized clinical trial. J Infect 2005; 50: 443-449 .
32. Pasqualotto AC, Nedel WL, Machado TS, Severo LC. Comparative study of risk factors and outcome among outpatient-acquired and nosocomial candidemia. J Hospital Infect 2005; 60: 129-134 .
33. Chung JW, Lee SO, Choi SH, e t al. Risk factors and outcome for breakthrough candidemia in patients with cancer. Cancer 2004; 101: 1860-1865 .
34. Kovacicova G, Spanik S, Kunova A, e t al. Prospective study of fungaemia in a single cancer institution over a 10-y period: etiology, risk factors, consumption of antifungals and outcome in 140 patients. Scand J Infect Dis 2001; 33: 367-374 .
35. Tortorano AM , Prigitano A, Biraghi E, Viviani MA on behalf of the FIMUA-ECMM Candidemia Study Group . The European Confederation of Medical Mycology (ECMM) survey of candidemia in Italy: in vitro susceptibility of 375 Candida albicans isolates and biofi lm production. J Antimicrob Chemother 2005; 56: 777-779 .
36. Boktour MR, Kontoyiannis DP, Hanna HA, e t al. Multiple-species candidemia in patients with cancer. Cancer 2004; 101: 1860-1865 .
37. Cuenca-Estrella M, Rodriguez D, Almirante B, e t al. In vitro susceptibilities of bloodstream isolates of Candida species to six antifungal agents: results from a population-based active surveillance programme, Barcelona, Spain, 2002-2003. J Antimicrob Chemother 2002; 55: 194-199 .
38. Sims CR, Paetznick VL, Rodriguez JR, Chen E, Ostrosky-Zeichner L. Correlation between microdilution, e-test, and disk diffusion methods for antifungal susceptibility testing of posaconazole against Candida spp. J Clin Microbiol 2006; 44: 2105-2108 .
39. Pfaller MA, Diekema DJ, Gibbs DL, et al. Geographic and temporal trends in the isolation and antifungal susceptibility of Candida parapsilosis : a global assessment from the ARTEMIS disk antifungal surveillance program 2001 to 2005. J Clin Microbiol 2008; 46: 842-849.
40. Wenzel R, Edmond M. The impact of hospital-acquired bloodstream infections. Emerg Infect Dis 2001; 7: 174-177 .
41. Tuon FF, Almeida G, Costa SF. Central venous catheter-associated fungemia due to Rhodotorula spp. - A systematic review. Med Mycol 2007; 45: 441-447 .
42. Bassetti S, Frei R, Zimmerli W. Fungemia with S accharomyces cerevisiae after treatment with Saccharomyces boulardii . Am J Med 1998; 105: 71-72 .
43. Llanos R, Querol A, Peman J, Gobernado M, Fernandez-Espinar MT. Food and probiotic strains from the Saccharomyces cerevisiae species as a possible origin of human systemic infections. Int J Food Microbiol 2006; 1: 286-290 .
44. Lunardi LW, Aquino VR, Zimerman RA, Goldani LZ. Epidemiology and outcome of Rhodotorula fungemia in a tertiary care hospital. Mycoses 2006; 49: 114-118.