Masitinib for the treatment of canine atopic dermatitis: A pilot study

Veterinary Research Communications

Volumn 34, Issue 1, 2010, Pages 51-63

  Daigle, Jenise ^a   Moussy, Alain ^b   Mansfield, Colin D ^b   Hermine, Olivier ^c  

^a Austin Veterinary Dermatology   (United States)

^b AB Science   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

C KIT; Canine atopic dermatitis; Masitinib; Pilot study; Tyrosine kinase inhibitor

Indexed keywords

MASITINIB MESILATE; MASIVET; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL LAMENESS; ANIMAL MODEL; ARTICLE; ATOPIC DERMATITIS; BLOOD TOXICITY; BODY SURFACE; CONTROLLED STUDY; DISEASE SEVERITY; DOG DISEASE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; FEMALE; FEVER; LETHARGY; LOOSE FECES; MALE; NEUTROPENIA; NONHUMAN; PILOT STUDY; PRURITUS; SCORING SYSTEM; STOMACH DISEASE; TREATMENT RESPONSE; URINE INCONTINENCE;

ANIMALS; DERMATITIS, ATOPIC; DOG DISEASES; DOGS; DRUG TOXICITY; PILOT PROJECTS; PRURITUS; SEVERITY OF ILLNESS INDEX; SKIN; THIAZOLES; TREATMENT OUTCOME;

CANIS FAMILIARIS;

EID: 76649091569     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11259-009-9332-2     Document Type: Article

References (29)

1. L Blackwood AJ German AJ Stell T O'Neill 2004 Multicentric lymphoma in a dog after cyclosporine therapy Journal of Small Animal Practice 45 259 62 10.1111/j.1748-5827.2004.tb00233.x 1:STN:280:DC%2BD2c3msVansQ%3D%3D 15163054
2. MB Callan D Preziosi E Mauldin 2005 Multiple papillomavirus-associated epidermal hamartomas and squamous cell carcinomas in situ in a dog following chronic treatment with prednisone and cyclosporine Veterinary Dermatology 16 338 45 10.1111/j.1365-3164.2005.00466.x 16238815 (Pubitemid 41626158)
3. F de Mora A Puigdemont R Torres 2006 The role of mast cells in atopy: What can we learn from canine models? A thorough review of the biology of mast cells in canine and human systems British Journal of Dermatology 155 1109 1123 10.1111/j.1365-2133.2006.07494.x 17107377 (Pubitemid 44729983)
4. DJ DeBoer CE Griffin 2001 The ACVD task force on canine atopic dermatitis (XXI): antihistamine pharmacotherapy Veterinary Immunology and Immunopathology 81 323 329 10.1016/S0165-2427(01)00306-3 1:CAS:528:DC%2BD3MXms12gtb0%3D 11553395 (Pubitemid 32842887)
5. Diesel, A & Moriello, K.A. (2008) A busy clinician's review of cyclosporine. Veterinary Medicine, May 1, 266-273.
6. Dubreuil, P., Letard, S., Ciufolini, M.A., Gros, L., Leventhal, P.S., Humbert, M., Castéran, N., Borge, L., Hajem, B., Lermet, A., Sippl, W., Voisset, E., Arock, M., Auclair, C., Leventhal, P.S., Mansfield, C.D., Moussy, A. & Hermine, O. (2009) Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting kit. PLoS One, 4(9):e7258.
7. AM Gilfillan C Tkaczyk 2006 Integrated signalling pathways for mast-cell activation Nature Review Immunology 6 218 230 10.1038/nri1782 1:CAS:528:DC%2BD28XhsleltLY%3D (Pubitemid 43290991)
8. CE Griffin DJ DeBoer 2001 The ACVD task force on canine atopic dermatitis (XIV): clinical manifestations of canine atopic dermatitis Veterinary Immunology and Immunopathology 81 255 269 10.1016/S0165-2427(01)00346-4 1:STN:280:DC%2BD3MrgsValsA%3D%3D 11553388 (Pubitemid 32850889)
9. CE Griffin A Hillier 2001 The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy Veterinary Immunology and Immunopathology 81 363 383 10.1016/S0165-2427(01)00348-8 1:CAS:528: DC%2BD3MXms12gurw%3D 11553398 (Pubitemid 32842890)
10. PB Hill T Olivry 2001 The ACVD task force on canine atopic dermatitis (V): biology and role of inflammatory cells in cutaneous allergic reactions Veterinary Immunology and Immunopathology 81 187 198 10.1016/S0165-2427(01) 00310-5 1:CAS:528:DC%2BD3MXms12gt7c%3D 11553379 (Pubitemid 32842874)
11. A Hillier CE Griffin 2001 The ACVD task force on canine atopic dermatitis (I): incidence and prevalence Veterinary Immunology and Immunopathology 81 147 151 10.1016/S0165-2427(01)00296-3 1:STN:280:DC%2BD3MrgsVanuw%3D%3D 11553375 (Pubitemid 32842870)
12. JP Kinet 2007 The essential role of mast cells in orchestrating inflammation Immunological Reviews 217 5 7 10.1111/j.1600-065X.2007.00528.x 1:CAS:528:DC%2BD2sXnt1Gmtbo%3D 17498047 (Pubitemid 46718159)
13. R Marsella T Olivry 2001 The ACVD task force on canine atopic dermatitis (XXII): nonsteroidal anti-inflammatory pharmacotherapy Veterinary Immunology and Immunopathology 81 331 345 10.1016/S0165-2427(01)00315-4 1:CAS:528: DC%2BD3MXms12gtbg%3D 11553396 (Pubitemid 32842888)
14. T Nuttall 2008 Management of atopic dermatitis Veterinary Focus 18 32 39
15. T Olivry E Guaguere D Heripret 1997 Treatment of canine atopic dermatitis with misoprostol, a prostaglandin E1 analogue: an open study Journal of Dermatological Treatment 8 243 247 10.3109/09546639709160529
16. T Olivry CA Sousa 2001a The ACVD task force on canine atopic dermatitis (XX): glucocorticoid pharmacotherapy Veterinary Immunology and Immunopathology 81 317 322 10.1016/S0165-2427(01)00314-2 1:CAS:528:DC%2BD3MXms12gtbw%3D (Pubitemid 32842886)
17. T Olivry CA Sousa 2001b The ACVD task force on canine atopic dermatitis (XIX): general principles of therapy Veterinary Immunology and Immunopathology 81 311 316 10.1016/S0165-2427(01)00347-6 1:STN:280:DC%2BD3MrgsValtQ%3D%3D (Pubitemid 32842885)
18. T Olivry DJ DeBoer CE Griffin 2001a The ACVD task force on canine atopic dermatitis: forewords and lexicon Veterinary Immunology and Immunopathology 81 143 146 10.1016/S0165-2427(01)00343-9 1:STN:280:DC%2BD3MrgsVanug%3D%3D (Pubitemid 32842869)
19. T Olivry R Marsella A Hillier 2001b The ACVD task force on canine atopic dermatitis (XXIII): are essential fatty acids effective? Veterinary Immunology and Immunopathology 81 347 362 10.1016/S0165-2427(01)00316-6 1:CAS:528:DC%2BD3MXms12gtbY%3D (Pubitemid 32842889)
20. T Olivry C Rivierre HA Jackson KM Murphy G Davidson CA Sousa 2002 Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomised prednisolone-controlled trial Veterinary Dermatology 13 77 87 10.1046/j.1365-3164.2002.00283.x 11972891 (Pubitemid 135712675)
21. T Olivry J Steffan RD Fisch P Prélaud E Guaguère J Fontaine DN Carlotti 2002b Randomized controlled trial of the efficacy of cyclosporine in the treatment of atopic dermatitis in dogs Journal of the American Veterinary Medical Association 221 370 377 10.2460/javma.2002.221.370 1:CAS:528: DC%2BD38XmsVaju7c%3D (Pubitemid 34809547)
22. T Olivry R Marsella T Iwasaki R Mueller 2007 Validation of CADESI-03, a severity scale for clinical trials enrolling dogs with atopic dermatitis Veterinary Dermatology 18 78 86 10.1111/j.1365-3164.2007.00569.x 17355421 (Pubitemid 46393250)
23. T Olivry R Mueller T Nuttall C Favrot P Prélaud 2008 Determination of CADESI-03 thresholds for increasing severity levels of canine atopic dermatitis Veterinary Dermatology 19 115 119 10.1111/j.1365-3164.2008.00668.x 18477326 (Pubitemid 351683543)
24. MM Oken RH Creech DC Tormey J Horton TE Davis ET McFadden T Eleanor P Carbone 1982 Toxicity and response criteria of the Eastern Cooperative Oncology Group American Journal of Clinical Oncology 5 649 655 10.1097/00000421- 198212000-00014 1:STN:280:DyaL3s7kvFOgsw%3D%3D 7165009
25. P Prélaud E Guaguere N Alhaidari N Faivre D Héripret A Gayerie 1998 Reevaluation of diagnostic criteria of canine atopic dermatitis Revue de Medecine Veterinaire 149 1057 1064
26. Randall, T.C. (2005). Canine atopic dermatitis: old and new therapies. In: Proceeding of the North American Veterinary Conference, Florida. pp. 285-288.
27. L Reber CA DaSilva N Frossard 2006 Stem cell factor and its receptor c-KIT as targets for inflammatory diseases European Journal of Pharmacology 533 327 340 10.1016/j.ejphar.2005.12.067 1:CAS:528:DC%2BD28XitVKgs7g%3D 16483568 (Pubitemid 43340024)
28. Scott, D.W., Miller, W.H. & Griffin, C.E. (Eds.) (2001) In: Small Animal Dermatology, 6th edn., pp. 574-601. W.B. Saunders, Philadelphia.
29. J Steffan D Alexander F Brovedani RD Fisch 2003 Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel, blinded, randomized controlled trial Veterinary Dermatology 14 11 22 10.1046/j.1365-3164.2003.00318.x 12603681 (Pubitemid 37248991)