Gemcitabine and capecitabine in combination for advanced anthracycline and taxane pre-treated breast cancer patients: A phase II study

Acta Oncologica

Volumn 49, Issue 1, 2010, Pages 35-41

  Malmström, Annika ^a   Hansen, Jörgen ^b   Malmberg, Lena ^c   Carlsson, Lena ^d   Svensson, Jan Henry ^e   Ahlgren, Johan ^f   Ahlin, Cecila ^g   Jansson, Tomas ^h   Westberg, Ronny ⁱ  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^b CENTRAL HOSPITAL   (Sweden)

^c RYHOV COUNTY HOSPITAL   (Sweden)

^d Clinical Department of Obstetrics and Gynaecology   (Sweden)

^e SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^f Gävleborg County Hospital   (Sweden)

^g ÖREBRO UNIVERSITY HOSPITAL   (Sweden)

^h TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

ⁱ RW Clinical Research   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRACYCLINE; CAPECITABINE; GEMCITABINE; TAXANE DERIVATIVE;

ADULT; AGED; ANOREXIA; ARTICLE; BONE METASTASIS; BREAST CANCER; BREAST METASTASIS; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; CONSTIPATION; DIARRHEA; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG FEVER; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FATIGUE; FEMALE; GRANULOCYTOPENIA; HAND FOOT SYNDROME; HUMAN; INFECTION; LEUKOPENIA; LIVER METASTASIS; MULTIPLE CYCLE TREATMENT; NAUSEA; NEUROPATHY; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; STOMATITIS; SURVIVAL TIME; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT FAILURE; VOMITING;

ADULT; AGED; ANTHRACYCLINES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; DEOXYCYTIDINE; DISEASE PROGRESSION; FEMALE; FLUOROURACIL; HUMANS; KAPLAN-MEIERS ESTIMATE; MIDDLE AGED; SALVAGE THERAPY; TAXOIDS;

EID: 76649090298     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/02841860903268031     Document Type: Article

References (16)

1. Silvestris N, Cinieri S, La Torre I, et al. Role of gemcitabine in metastatic breast cancer patients: A short review. Breast 2008; 17:220-6.
2. Ershler W. Capecitabine monotherapy: Safe and effective treatment for metastatic breast cancer. Oncologist 2006; 11:325-35.
3. Sawada N, Fujimoto-Ouchi K, Ishikawa T, et al. Antitumor activity of combination therapy with capecitabine plus vinorelbin, and capecitabine plus gemcitabine in human tumor xenograft models. Proc Am Assoc Cancer Res 2002; 43:5388 (Abstract).
4. Andres R, Mayordomo JI, Lara R, et al. Gemcitabine/capecitabine in patients with metastatic breast cancer pretreated with anthracyclines and taxanes. Clin Breast Cancer. 2005; 6:158-62.
5. Benekli M, Yildis R, Uner A, et al. Gemcitabine plus capecitabine combination in metastatic breast cancer patients previously treated with anthracyclines and taxanes. Oncology 2007; 72:308-13.
6. Giannessi P, Martell F, Di Marsico R, et al. Gemcitabine in combination with capecitabine in metastatic breast carcinoma: A phase I-II study. J Clin Oncol 2005; 23 ( Suppl ): 870 (Abstract).
7. Sikov WM, Theall KP, Seidler R, et al. Gemcitabine and capecitabine in metastatic breast cancer (MBC): Brown University Oncology group (BrUOG) phase II study. J Clin Oncol 2005; 23 ( Suppl ): 785 (Abstract).
8. Ahn J, Kim S, Lee Y, et al. Phase II study of gemcitabine and capecitabine in patients with metastatic breast cancer pre-treated with anthracyclines and taxanes. J Clin Oncol 2005; 23 ( Suppl ): 895 (Abstract).
9. Teletaeva G, Erndiev S, Moiseyenko V. Phase II trial of Gemcitabine and Capecitabine combination in patients with metastatic breast cancer resistant to standard therapy. Ann Oncol 2003; 14 ( Suppl 3 ): 66 (Abstract).
10. Pérez-Manga G, López-Criado P, Mendez M, et al. Gemcitabine (G) plus capecitabine (C) in previously treated metastatic breast cancer (MBC) patients. Final results from a phase II GOTI trial. Breast Cancer Res Treat 2004; 88 ( Suppl 1 ): 5063 (Abstract).
11. Wirk B, Perez E. Role of gemcitabine in breast cancer management: An update. Semin Oncol 2006; 33: S6-14.
12. Seidman A, O'Shaughnessy J, Misset JL. Single-agent capecitabine: A reference treatment for taxane-pretreated metastatic breast cancer? Oncologist 2002; 7 ( Suppl 6 ): 20-8.
13. Albain K, Nag S, Calderillo-Ruiz G, et al. gemcitabine plus paclitaxel versus paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment. J Clin Oncol 2008; 26:3950-7.
14. O'Shaughnessy J, Miles D, Vukelja S, et al. Superior survival with capecitabine plus docetaxel combination therapy in anthracycline-pretreated patients with advanced breast cancer: Phase III trial results. J Clin Oncol 2002; 20:2812-23.
15. Chan S. Gemcitabine plus Docetaxel versus capecitabine plus docetaxel for patients with anthracycline-pretreated metastatic breast cancer: A review of results of a European Phase III trial. EJC 2005; ( Suppl 3 ): 17-21.
16. Fleming TR. One-sample multiple testing procedure for phase II clinical trials. Biometrics 1982; 38:143-51.