Expression of Twist, E-cadherin and N-cadherin in breast carcinoma and their clinical significance

Chinese Journal of Pathology

Volumn 39, Issue 1, 2010, Pages 5-9

  Ma, Yi Hui ^a   Wang, Kai ^a   Ll, Lei ^a   Lu, Zhao Hui ^a   Chen, Jie ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

Breast neoplasm; Cadherins; Neoplasm metastasis; Twist transcription

Indexed keywords

CADHERIN; TRANSCRIPTION FACTOR TWIST;

ADULT; AGED; ARTICLE; BREAST TUMOR; CARCINOMA IN SITU; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; LYMPH NODE METASTASIS; METABOLISM; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CADHERINS; CARCINOMA IN SITU; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MIDDLE AGED; TWIST TRANSCRIPTION FACTOR;

EID: 76549118623     PISSN: 05295807     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0529-5807.2010.01.003     Document Type: Article

References (14)

1. Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell, 2004, 117(7):927-939. (Pubitemid 38798858)
2. Agiostratidou C, Hulit J, Phillips CR, et al. Differential Cadherin expression potential markers for epithelial to mesenchymal transformation during tumor progerssion. J Mammary Cland Biol Neoplasia, 2007, 12(2-3); 127-133. (Pubitemid 47215430)
3. Tavassoli FA, Devilee P. World Health Organization classification of tumours. Pathology and genetics of tumours of the breast and female genital organs. Lyon: IARC Press, 2003;1963-1967.
4. Nakajima S, Doi R, Toyoda E, et al. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res, 2004, 10(12 Pt 1) 4125-4133 (Pubitemid 38812492)
5. Thisse B, el Messal M, Perrin-Schmitt F. The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern. Nucleic Acids Res, 1987, 15(8) 3439-3453.
6. Rosivatz E, Becker I, Specht K, et al. Differential expression of the epithelial-mesenchymal transition regulators snail, SIPl, and twist in gastric cancer. Am J Pathol, 2002, 161(5) 1881-1891. (Pubitemid 35265545)
7. Kwok WK, Ling MT, Lee TW, et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res, 2005, 65(12) 5153-5162. (Pubitemid 40827324)
8. Martin TA, Goyal A, Watkins G, et ai. Expression of the transcription factors Snail, Slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol, 2005, 12 (6) 488-496.
9. Alexander NR, Tran NL, Rekapally H, et al. N-cadherin gene expression in prostate carcinoma is modulated by integrindependent nuclear translocation of Twist 1. Cancer Res, 2006, 66 (7): 3365-3369.
10. Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer, 2002, 2(6): 442-454.
11. Hazan RB, Phillips GR, Qiao RF, et al. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol, 2000, 148(4): 779-790.
12. Chetty R, Serra S. Nuclear E-cadherin immunoexpression: from biology to potential applications in diagnostic pathology. Adv Anat Pathol, 2008, 15(4): 234-240.
13. Serra S, Salahshor S, Fagih M, et al. Nuclear expression of E-cadherin in solid pseudopapillary tumors of the pancreas. JOP, 2007, 8(3): 296-303. (Pubitemid 46876788)
14. Chetty R, Serra S, Asa SL. Loss of membrane localization and aberrant nuclear E-cadherin expression correlates with invasion in pancreatic endocrine tumors. Am J Surg Pathol, 2008, 32 ( 3 ) : 413419.