Quantitation of polar analytes using column-switching: Application to oxycodone and three metabolites in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 7-8, 2010, Pages 637-644

  Wagner, M ^a,b   Bourgogne, E ^a,b   Varesio, E ^a,b   Hopfgartner, G ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Column switching; Mass spectrometry; Opioid receptor agonist; Plasma; Quantitative analysis

Indexed keywords

ALKALINE CONDITIONS; ANALYTES; ATMOSPHERIC PRESSURE CHEMICAL IONIZATION; CLINICAL STUDY; COLUMN-SWITCHING; HUMAN PLASMAS; IONIZATION MODES; LC-MS/MS; LIQUID CHROMATOGRAPHY COUPLED TO TANDEM MASS SPECTROMETRY; MASS SPECTROMETRIC DETECTION; MATRIX INTERFERENCE; MOBILE PHASE; NOROXYMORPHONE; OPIOID RECEPTOR AGONIST; OPIOID RECEPTORS; PERCHLORIC ACIDS; PLASMA SAMPLES; PLASMA VOLUME; POLAR ANALYTES; PROSPEKT; PROTEIN PRECIPITATION; QUANTITATIVE ANALYSIS; REVERSED-PHASE COLUMNS; SAMPLE CLEAN-UP; SAMPLE PREPARATION; SELECTED REACTION MONITORING; STUDY SAMPLES;

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; CHEMICAL DETECTION; CHROMATOGRAPHIC ANALYSIS; DESORPTION; FORMIC ACID; INORGANIC ACIDS; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLISM; METABOLITES; METHANOL; ORGANIC ACIDS; PARTICLE DETECTORS; PLASMA (HUMAN); PLASMAS; PROJECTILES; RESINS; SWITCHING;

COLUMN CHROMATOGRAPHY;

DRUG METABOLITE; FORMIC ACID; METHANOL; NOROXYCODONE; NOROXYMORPHONE; OXYCODONE; OXYMORPHONE; PERCHLORIC ACID; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; COLUMN SWITCHING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELUTION; HUMAN; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, LIQUID; HUMANS; HYDROGEN-ION CONCENTRATION; LEAST-SQUARES ANALYSIS; MORPHINANS; OXYCODONE; OXYMORPHONE; PERCHLORIC ACID; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 76549087624     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.014     Document Type: Article

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